Results 121 to 130 of about 94,650 (353)
Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity. [PDF]
, 2019 Kinesin force generation involves ATP-induced docking of the neck linker (NL) along the motor core. However, the roles of the proposed steps of NL docking, cover-neck bundle (CNB) and asparagine latch (N-latch) formation, during force generation are ...
Budaitis, Breane G +8 more
core +1 more source
PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential
Cytoskeleton, EarlyView.ABSTRACT Centrosomes catalyze the assembly of a microtubule‐based bipolar spindle, essential for the precise chromosome segregation during cell division. At the center of this process lies Polo‐Like Kinase 4 (PLK4), the master regulator that controls the duplication of the centriolar core to ensure the correct balance of two centrosomes per dividing ...
Muhammad Hamzah +2 more
wiley +1 more source
Robust and stable transcriptional repression in Giardia using CRISPRi. [PDF]
, 2019 Giardia lamblia is a binucleate protistan parasite causing significant diarrheal disease worldwide. An inability to target Cas9 to both nuclei, combined with the lack of nonhomologous end joining and markers for positive selection, has stalled the ...
Booker, J +7 more
core +1 more source
Molecular Mechanisms for Microtubule Length Regulation by Kinesin-8 and XMAP215 Proteins
, 2014 The cytoskeleton is regulated by a plethora of enzymes that influence the stability and dynamics of cytoskeletal filaments. Molecular motors of the kinesin-8 protein family depolymerise microtubules in a length-dependent manner, and experimental and ...
Frey, Erwin +2 more
core +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Microtubules consist of parallel protofilament lanes for motor-based intracellular transport. While most motors translocate along individual protofilaments, members of the kinesin-8 family have been reported to sidestep.
A. Mitra, F. Ruhnow, S. Girardo, S. Diez
semanticscholar +1 more source
The NLS3 Motif in TPX2 Regulates Spindle Architecture in Xenopus Egg Extracts
Cytoskeleton, EarlyView.ABSTRACT A bipolar spindle composed of microtubules and many associated proteins functions to segregate chromosomes during cell division in all eukaryotes, yet both spindle size and architecture vary dramatically across different species and cell types.
Guadalupe E. Pena +4 more
wiley +1 more source
PEK14: A Kinesin‐4 Necessary for Male‐Derived Fertility in Arabidopsis thaliana
Cytoskeleton, EarlyView.ABSTRACT Of the 61 kinesins annotated in Arabidopsis thaliana, many are still without assigned function. Here, we have screened an insertional mutant library of Arabidopsis pollen‐expressed kinesins for fertility defects. Insertional mutants for three kinesins showed a significant reduction in seed set.
Isabella N. Mendes +6 more
wiley +1 more source
Molecular motors: design, mechanism and control
, 2008 Biological functions in each animal cell depend on coordinated operations of a wide variety of molecular motors. Some of the these motors transport cargo to their respective destinations whereas some others are mobile workshops which synthesize ...
Chowdhury, Debashish
core +1 more source
Journal of Cell Biology, 2017 Cytoplasmic inclusions of the RNA-binding protein fused in sarcoma (FUS) represent one type of membraneless ribonucleoprotein compartment. Formation of FUS inclusions is promoted by amyotrophic lateral sclerosis (ALS)–linked mutations, but the cellular ...
Kyota Yasuda +4 more
semanticscholar +1 more source
Cytoskeleton, EarlyView.ABSTRACT Of the three types of cytoskeleton known in animals—actin, microtubules, and intermediate filaments—only actin and microtubules exist in plants. Both play important roles in cellular shaping, organelle movement, organization of the endomembrane system, and cell signaling.
Norman R. Groves +3 more
wiley +1 more source