Chromosome 20q Amplification Regulates Response to Kinesin-5 Inhibitor
Cancer Informatics, 2008 We identified gene expression signatures predicting responsiveness to a Kinesin-5 (KIF11) inhibitor (Kinesin-5i) in cultured colon tumor cell lines.
Aimee L. Jackson +7 more
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PLoS Pathogens, 2010 Vaccinia virus (VACV) uses microtubules for export of virions to the cell surface and this process requires the viral protein F12. Here we show that F12 has structural similarity to kinesin light chain (KLC), a subunit of the kinesin-1 motor that binds ...
Gareth W Morgan +5 more
doaj +1 more source
Effects of Obstacles on the Dynamics of Kinesins, Including Velocity and Run Length, Predicted by a Model of Two Dimensional Motion. [PDF]
PLoS ONE, 2016 Kinesins are molecular motors which walk along microtubules by moving their heads to different binding sites. The motion of kinesin is realized by a conformational change in the structure of the kinesin molecule and by a diffusion of one of its two heads.
Woochul Nam, Bogdan I Epureanu
doaj +1 more source
Electro-detachment of kinesin motor domain from microtubule in silico
Computational and Structural Biotechnology Journal, 2023 Kinesin is a motor protein essential in cellular functions, such as intracellular transport and cell-division, as well as for enabling nanoscopic transport in bio-nanotechnology.
Jiří Průša, Michal Cifra
doaj +1 more source
Mechanism of unidirectional movement of kinesin motors
, 2003 Kinesin motors have been studied extensively both experimentally and theoretically. However, the microscopic mechanism of the processive movement of kinesin is still an open question.
Dou, Shuo-Xing, Wang, Peng-Ye, Xie, Ping
core +1 more source
DSK1, a novel kinesin-related protein from the diatom Cylindrotheca fusiformis that is involved in anaphase spindle elongation. [PDF]
, 1996 We have identified an 80-kD protein that is involved in mitotic spindle elongation in the diatom Cylindrotheca fusiformis. DSK1 (Diatom Spindle Kinesin 1) was isolated using a peptide antibody raised against a conserved region in the motor domain of the ...
Brady, B +3 more
core +2 more sources
Intracellular cargo transport by single-headed kinesin motors
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Intracellular transport is driven by molecular motors that carry cargoes along cytoskeletal tracks. Molecular motors, such as kinesin-1, contain two motor domains so they can walk processively (take many steps per encounter) along a ...
Kristin I Schimert +4 more
semanticscholar +1 more source
Journal of Cell Science, 2004 Dagenbach, E. M. and Endow, S. A. (2004). A new kinesin tree. J. Cell Sci. 117 , [3-7][1]. The neck analysis entries in Table 1 were not aligned correctly in both the print and online versions of this paper. The corrected [Table 1][2] is shown below. We apologise for any inconvenience caused.
Sharyn A. Endow, Elise M. Dagenbach
openaire +3 more sources
Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells. [PDF]
, 1992 To understand the interactions between the microtubule-based motor protein kinesin and intracellular components, we have expressed the kinesin heavy chain and its different domains in CV-1 monkey kidney epithelial cells and examined their distributions ...
Bernstein, HD +6 more
core
Fluctuating Currents in Stochastic Thermodynamics II. Energy Conversion and Nonequilibrium Response in Kinesin Models [PDF]
, 2015 Unlike macroscopic engines, the molecular machinery of living cells is strongly affected by fluctuations. Stochastic Thermodynamics uses Markovian jump processes to model the random transitions between the chemical and configurational states of these ...
Altaner, Bernhard +2 more
core +2 more sources