Results 161 to 170 of about 29,043 (290)

Dynein‐Dependent Endo‐Lysosomal Degradation Drives Lewy Body Disorders Accompanied by Aβ Pathology

Advanced Science, Volume 12, Issue 37, October 6, 2025.
This study investigates the impact of Aβ plaques on α‐synuclein (αSyn) pathologies in dementia with Lewy bodies (DLB). Co‐culturing primary neurons with AD mouse brain slices reveals impaired dynein‐dependent organelle trafficking, affecting αSyn degradation. Activating Rab7 restores this process, reducing αSyn inclusions.
Linlin Zhou, Yuwei Wang, Yu Liu, Feipeng Zhu, Ge Gao, Chengjie Li, Pu Ai, Jingying Xu, Junxin Wang, Long Guo, Yuting Guan, Virginia Man‐Yee Lee, Jianjun Chen, Jialin Zheng, Qihui Wu   +14 more
wiley   +1 more source

Activation of Lysosomal Retrograde Transport Triggers TPC1‐IP3R1 Ca2+ Crosstalk at Lysosome‐ER MCSs Leading to Lethal Depleting of ER Calcium

Advanced Science, Volume 12, Issue 39, October 20, 2025.
The flavonoid compound LW‐213 exerts its antitumor effects through a novel mechanism involving lysosomal‐ER calcium regulation. Specifically, LW‐213 binds to LIMP2, which induces perinuclear clustering of lysosomes and facilitates calcium‐mediated lysosome‐ER interactions.
Meng‐yuan Zhu, Yong‐jian Guo, Yu‐qi Zhu, Hong‐zheng Wang, Hai‐di Wang, Hong‐yu Chen, Yue‐xin Jiang, Hui Li, Hui Hui   +8 more
wiley   +1 more source

Direct Sequencing of 5‐Methylcytosine and 5‐Hydroxymethylcytosine at Single‐Base Resolution Unravels Their Distinct Roles in Alzheimer's Disease

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This study introduces two orthogonal sequencing methods, CMD1‐Deaminase sequencing (CD‐seq) and CMD1‐TET bisulfite sequencing (CT‐seq), that enable direct, independent detection of 5mC. Using these approaches together with ACE‐seq or TAB‐seq for 5hmC identification, the study reveals a significant reduction in 5hmC, but not 5mC, in the hippocampus of ...
Zi‐Xin Wang, Faying Chen, Bao‐Dan He, Fan‐Chen Wang, Jiaxue Cha, Yu Song, Wei‐Ying Meng, Wan‐Yue Zou, Yu‐Tao Fu, Shu‐Xia Sun, Zhi‐Yan Sun, Hao‐Ming Jiang, Ke‐Yao Zhao, Yujun Hou, Jiejun Shi, Jian‐Huang Xue   +15 more
wiley   +1 more source

The rate-limiting step in microtubule-stimulated ATP hydrolysis by dimeric kinesin head domains occurs while bound to the microtubule.

, 1994
David D. Hackney
openalex   +1 more source

Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome [PDF]

, 1997
Terunaga Nakagawa, Yosuke Tanaka, Eiji Matsuoka, Satoru Kondo, Yasushi Okada, Yasuko Noda, Yoshimitsu Kanai, Nobutaka Hirokawa   +7 more
openalex   +1 more source

Soybean Synergies: A Comprehensive Review on Novel Extraction Techniques and Their Role in Unlocking Health Potential

Food Science &Nutrition, Volume 13, Issue 10, October 2025.
Almost 18%–22% of soybean is comprised of tiny, stable oil bodies with a concentration of triacylglycerol, rich in bioactive substances. These oil bodies of soybean consist of oleosins, oleosins, and steroleosin as part of the monolayer of phospholipids.
Muhammad Rashid, Iqra Khalid, Gaurav Sanghvi, Amar Shankar, Farhan Saeed, Muhammad Afzaal, Mehwish, Mayank Kundlas, Catherine Tamale Ndagire   +8 more
wiley   +1 more source

Different Contribution of Missense and Loss‐of‐Function Variants to the Genetic Structure of Familial and Sporadic Meniere Disease

MedComm, Volume 6, Issue 10, October 2025.
This study examines the genetic basis of sporadic (SMD) and familial Meniere disease (FMD) by comparing rare protein‐coding variants using exome sequencing and gene burden analysis. FMD patients had a higher accumulation of missense and LoF variants, especially in genes linked to auditory and vestibular function.
Alberto M. Parra‐Perez, Alvaro Gallego‐Martinez, Alba Escalera‐Balsera, Paula Robles‐Bolivar, Patricia Perez‐Carpena, Jose A. Lopez‐Escamez   +5 more
wiley   +1 more source

Does microtubule motor-mediated centrosomal dyshomeostasis confer chemoresistance in breast cancer? [PDF]

J Mammary Gland Biol Neoplasia
Priyanga J, Guha G, Bhakta-Guha D.
europepmc   +1 more source

High-resolution tracking of microtubule motility driven by a single kinesin motor.

, 1994
Fady I. Malik, David R. Brillinger, R D Vale   +2 more
openalex   +1 more source

Diabetic Wound Repair: From Mechanism to Therapeutic Opportunities

MedComm, Volume 6, Issue 10, October 2025.
Diabetic wound healing is compromised by chronic metabolic dysfunction that disrupts essential cellular processes. This review examines key predisposing factors, including neuropathy and vascular disease, characterizes dysfunction in critical cell types such as macrophages and fibroblasts, evaluates limitations of current models, compares established ...
Renyuan Wang, Song Gu, Young Hwa Kim, Aejin Lee, Haodong Lin, Dongsheng Jiang   +5 more
wiley   +1 more source