Results 171 to 180 of about 14,118 (183)
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Trends in Cell Biology, 2002
Kinesins are motor proteins that move cargoes such as vesicles, organelles and chromosomes along microtubules. They are best known for their role in axonal transport and in mitosis. There is a diverse family of kinesins, members of which differ in composition and functions.
Mandelkow, Eckhard, Mandelkow, Eva-Maria
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Kinesins are motor proteins that move cargoes such as vesicles, organelles and chromosomes along microtubules. They are best known for their role in axonal transport and in mitosis. There is a diverse family of kinesins, members of which differ in composition and functions.
Mandelkow, Eckhard, Mandelkow, Eva-Maria
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Biochemistry, 2007
Several lines of experimental evidence suggest that the conventional kinesin 1 walks by an asymmetric hand-over-hand mechanism, although it is a homodimer. In the previous study, we examined several important force-dependent features of the hand-over-hand mechanism of kinesin. In this study, we focus on the asymmetry in the hand-over-hand mechanism. We
Qiang Shao, Yi Qin Gao
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Several lines of experimental evidence suggest that the conventional kinesin 1 walks by an asymmetric hand-over-hand mechanism, although it is a homodimer. In the previous study, we examined several important force-dependent features of the hand-over-hand mechanism of kinesin. In this study, we focus on the asymmetry in the hand-over-hand mechanism. We
Qiang Shao, Yi Qin Gao
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Nature, 2005
Kinesin is a molecular walking machine that organizes cells by hauling packets of components directionally along microtubules. The physical mechanism that impels directional stepping is uncertain. We show here that, under very high backward loads, the intrinsic directional bias in kinesin stepping can be reversed such that the motor walks sustainedly ...
Robert A. Cross, Nicholas J Carter
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Kinesin is a molecular walking machine that organizes cells by hauling packets of components directionally along microtubules. The physical mechanism that impels directional stepping is uncertain. We show here that, under very high backward loads, the intrinsic directional bias in kinesin stepping can be reversed such that the motor walks sustainedly ...
Robert A. Cross, Nicholas J Carter
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Flagellar Kinesins in Protists
Future Microbiology, 2011Cilia and flagella are organelles of the cell body present in many eukaryotic cells. Although their basic structure is well conserved from unicellular organisms to mammals, they show amazing diversity in number, structure, molecular composition, disposition and function.
Linda Kohl, William Marande
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Kinesins in the nervous system
Cellular and Molecular Life Sciences (CMLS), 1999Both the development and the maintenance of neurons require a great deal of active cytoplasmic transport. Much of this transport is driven by microtubule motor proteins. Membranous organelles and other macromolecular assemblies bind motor proteins that then use cycles of adenosine 5'-triphosphate hydrolysis to move these 'cargoes' along microtubules ...
M. A. E. Martin +2 more
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Nature Structural Biology, 1996
The first high resolution structures of the kinesin and NCD motor proteins reveal their surprising similarity to myosin but leave open the tantalizing question of what properties determine the directionality of movement along microtubules.
Roman Sakowicz, Lawrence S.B. Goldstein
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The first high resolution structures of the kinesin and NCD motor proteins reveal their surprising similarity to myosin but leave open the tantalizing question of what properties determine the directionality of movement along microtubules.
Roman Sakowicz, Lawrence S.B. Goldstein
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Trends in Neurosciences, 2018
Active intracellular transport of organelles relies on the coordinated activities of cytoplasmic dynein and kinesin, ATP-dependent microtubule motor proteins. While axonemal dynein was discovered during the mid-1960s, it was not until the mid-1980s that kinesin was discovered by Ron Vale and colleagues, as reported in 1985.
Erika L.F. Holzbaur, Eva Klinman
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Active intracellular transport of organelles relies on the coordinated activities of cytoplasmic dynein and kinesin, ATP-dependent microtubule motor proteins. While axonemal dynein was discovered during the mid-1960s, it was not until the mid-1980s that kinesin was discovered by Ron Vale and colleagues, as reported in 1985.
Erika L.F. Holzbaur, Eva Klinman
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The Mechanochemistry of Kinesin
Molecular and Chemical Neuropathology, 1990The mechanochemical protein kinesin is believed to play an important role in intracellular vesicle movements, including the anterograde motion of axoplasmic transport. This article reviews some of the pharmacological and biochemical information about kinesin, particularly with respect to the properties of nucleotide-dependent microtubule binding ...
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2012
The mammalian genome possesses 45 unique genes that code for kinesins. Kinesins are motor molecules, ATPases, which are specialized for the transport of cellular materials along the surface of cellular microtubules. Microtubules consist of linear polymers of repeating 8-nm-long tubulin dimers, each of which comprises one binding site for the kinesin ...
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The mammalian genome possesses 45 unique genes that code for kinesins. Kinesins are motor molecules, ATPases, which are specialized for the transport of cellular materials along the surface of cellular microtubules. Microtubules consist of linear polymers of repeating 8-nm-long tubulin dimers, each of which comprises one binding site for the kinesin ...
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Rice kinesin O12 is identical to kinesin OsKCH1
Journal of Biochemistry, 2012Shinsaku Maruta +4 more
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