Results 121 to 130 of about 117,673 (373)

Kinetochore dynein is sufficient to biorient chromosomes and remodel the outer kinetochore

Nature Communications
Multiple microtubule-directed activities concentrate on mitotic chromosomes to ensure their faithful segregation. These include couplers and dynamics regulators localized at the kinetochore, the microtubule interface built on centromeric chromatin, as ...
Bram Prevo, Dhanya K. Cheerambathur, William C. Earnshaw, Arshad Desai   +3 more
doaj   +1 more source

Kinetochore alignment within the metaphase plate is regulated by centromere stiffness and microtubule depolymerases [PDF]

, 2010
During mitosis in most eukaryotic cells, chromosomes align and form a metaphase plate halfway between the spindle poles, about which they exhibit oscillatory movement. These movements are accompanied by changes in the distance between sister kinetochores,
Amaro, Ana C., Danuser, Gaudenz, Dorn, Jonas F., Elliott, Hunter L., Jaqaman, Khuloud, King, Emma M., McAinsh, Andrew D., McClelland, Sarah E., Mchedlishvili, Nunu, Meraldi, Patrick, Porter, Iain M., Posch, Markus, Swedlow, Jason R., Toso, Alberto, Winter, Jennifer R.   +14 more
core   +6 more sources

EIF5A Couples Translational Control With Transcriptional Reprogramming Through Chromocenter Reorganization During Spermiogenesis

Advanced Science, EarlyView.
The translation factor Eukaryotic translation initiation factor 5A (eIF5A) is essential for male fertility in mice. It supports the translation of proteins crucial for heterochromatin organization and acrosome formation. eIF5A deficiency disrupts chromocenter integrity, increases chromatin accessibility, and causes transcriptional dysregulation ...
Yuling Cai, Tongtong Li, Qian Fang, Ziyou Bao, Feng Kong, Huitao Qi, Hanzhen Li, Mingyu Zhang, Wei Wang, Yongxia Guan, Wenbo Liu, Xiangfeng Chen, Zi‐Jiang Chen, Xiaohua Jiang, Xin Wang, Hongbin Liu   +15 more
wiley   +1 more source

AI-Assisted Forward Modeling of Biological Structures

Frontiers in Cell and Developmental Biology, 2019
The rise of machine learning and deep learning technologies have allowed researchers to automate image classification. We describe a method that incorporates automated image classification and principal component analysis to evaluate computational models
Josh Lawrimore, Ayush Doshi, Benjamin Walker, Kerry Bloom   +3 more
doaj   +1 more source

Kinesin-12 KLP-18 contributes to the kinetochore-microtubule poleward flux during the metaphase of C. elegans one-cell embryo [PDF]

, 2022
Nina Soler, Laurent Chesneau, Hélène Bouvrais, Sylvain Pastezeur, Loïc Le Marrec, Jacques Pécréaux, Sylvain Pastezeur, Loïc Le Marrec, Jacques Pecreaux   +8 more
openalex   +1 more source

Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells

Nature Communications, 2017
Human chromosomes are captured along microtubule walls (lateral attachment) and then tethered to microtubule-ends (end-on attachment) through a multi-step end-on conversion process. Upstream regulators that orchestrate this remarkable change in the plane
Roshan L. Shrestha, Duccio Conti, Naoka Tamura, Dominique Braun, R. Ramalingam, Konstanty Cieslinski, J. Ries, Viji M. Draviam   +7 more
semanticscholar   +1 more source

Mechanisms mitigating problems with multiple kinetochores on one microtubule in early mitosis [PDF]

, 2017
Proper chromosome segregation in mitosis relies on correct kinetochore interaction with spindle microtubules. In early mitosis, each kinetochore usually interacts with the lateral side of each microtubule and is subsequently tethered at the microtubule ...
Amberg, Bressan, Brun, Cheerambathur, Dujon, Franco, Gachet, Gandhi, Grishchuk, Haruki, Hill, Kalantzaki, Kalinina, King, Kitamura, Kitamura, Kubota, Maure, Michaelis, Nishimura, O'Reilly, O'Toole, Richmond, Rieder, Shrestha, Straight, Straight, Tanaka, Tanaka, Tanaka, Tanaka, Tanaka, Tanaka, Tanaka, Uhlmann, Vasileva, Vorozhko, Winey, Winey, Yang   +39 more
core   +3 more sources

Genome‐Wide Association Analyses Reveal the Genetic Basis of EMS Mutagenesis Efficiency in Rice

Advanced Science, EarlyView.
Based on large‐scale screening of 420 rice accessions, GWAS identified the Rc locus as a key regulator of EMS mutagenesis efficiency. Functional Rc alleles enhance both seed survival and genome‐wide mutation frequency by boosting antioxidant enzyme activities (CAT, SOD, POD) and reducing oxidative damage.
Peizhou Xu, Qinglu Zhang, Le Xue, Zhen Zhang, Nanhui Luo, Zhaoyang Cheng, Duo Xia, Shuqin Zheng, Xianjun Wu, Hao Zhou   +9 more
wiley   +1 more source

CDK-dependent phosphorylation and nuclear exclusion coordinately control kinetochore assembly state [PDF]

, 2013
Accurate chromosome segregation requires assembly of the multiprotein kinetochore complex. Prior work has identified more than 100 different kinetochore components in human cells. However, little is known about the regulatory processes that specify their
Carroll, Cheeseman, Cheeseman, Cheeseman, Davies, Eskat, Gascoigne, Gascoigne, Glotzer, Guse, Hellwig, Hori, Howell, Iain M. Cheeseman, Jansen, Karen E. Gascoigne, Kim, Kornbluth, Li, Malumbres, McClelland, Nishino, Perpelescu, Peters, Schmidt, Schmitz, Venkei   +26 more
core   +2 more sources

Disrupting Lipid Raft Microdomains to Block Polyploid Giant Cancer Cell Budding and Enhance Radiotherapy Response

Advanced Science, EarlyView.
Radiation induces polyploid giant cancer cells (PGCCs) that regenerate tumors through virus‐like budding. This process depends on a SNCG–FLOT2–CHMP4B signaling axis functioning in lipid raft microdomains. Disrupting these domains using statins or anti‐PCSK9 antibodies blocks PGCC budding, suppresses tumor repopulation, and enhances radiotherapy ...
Zheng Deng, Haoran Sun, Jin Cheng, Ruyi Zhao, Jianzhu Xie, Yanwei Song, Yucui Zhao, Chenwei Lin, Binjie Hu, Yanping Gong, Jun Lin, Sijia He, Yuntao Luo, Minghui Zhao, Yiwei Wang, Ming Jiao, Yuqin Yang, Jikun Li, Shujie Xia, Chuanyuan Li, Qian Huang   +20 more
wiley   +1 more source