Results 151 to 160 of about 44,237 (280)
Visualization of Mad2 Dynamics at Kinetochores, along Spindle Fibers, and at Spindle Poles in Living Cells [PDF]
, 2000 Bonnie J. Howell +4 more
openalex +3 more sources
Protein dynamics at the kinetochore: cell cycle regulation of the metaphase to anaphase transition [PDF]
, 1999 Gary J. Gorbsky +3 more
openalex +1 more source
Asia-Pacific Journal of Clinical Oncology, EarlyView.Investigating the diagnostic potential and functional role of CDCA genes in breast cancer. ABSTRACT Background The cell division cycle‐associated (CDCA) genes regulate key cellular processes like cell cycle progression and division. This study evaluates the diagnostic and clinical relevance of CDCA genes in breast cancer.
Yongsheng Zhao, Xiaocha Ma, Jun Zhou
wiley +1 more source
The use of deidentified organ donor testes for research
Andrology, EarlyView.Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova +4 more
wiley +1 more source
Cerebellar defects are a primary pathology in mouse models of spinal muscular atrophy
Brain Pathology, EarlyView.Purkinje cell (PC) degeneration is localized to posterior lobules in the cerebellum, and rescue of survival motor neuron protein expression levels in motor neurons does not ameliorate this effect. Representative images of sagittal cerebellar sections stained with anti‐calbindin in the vermis and hemisphere at P12 for wild type, ChATCre+ rescue (Rescue),
Nicholas C. Cottam +9 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley +1 more source
Fin1-PP1 Helps Clear Spindle Assembly Checkpoint Protein Bub1 from Kinetochores in Anaphase
Cell Reports, 2016 Summary: The spindle assembly checkpoint (SAC) monitors chromosome attachment defects, and the assembly of SAC proteins at kinetochores is essential for its activation, but the SAC disassembly process remains unknown.
Michael Bokros +4 more
doaj
Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere-kinetochore complexes [PDF]
, 2000 Naoko Yoshizawa-Sugata
openalex +1 more source
Nuclear destabilisation – a possible genesis of cancer?
Biological Reviews, EarlyView.ABSTRACT This review examines the increasingly prominent role of mechanics within cancer formation and progression. The extremely varied and contradictory genetic landscape of cancer is in stark contrast to the seemingly universal mechanical characteristics of cancer cells and their tumour microenvironment, and mechanics may be a principal unifying ...
Daniel D. Scott +4 more
wiley +1 more source