Results 161 to 170 of about 89,793 (256)

Microtubules guide Aurora B substrate geometries for accurate chromosome segregation. [PDF]

Sci Adv
Niu Y, DeLuca KF, Owen RH, Konishi HA, Gong R, Alushin GM, DeLuca JG, Funabiki H.   +7 more
europepmc   +1 more source

Technologies for engineering repetitive DNA

Quantitative Biology, Volume 14, Issue 3, September 2026.
Abstract Repetitive DNA, a fundamental architectural element of genomes, is widespread across organisms and comprises about 54% of the human genome. With advances in long‐read sequencing and bioinformatics approaches, highly repetitive sequences can now be characterized in depth.
Shuting Ma, Yali Cui, Yi Wu
wiley   +1 more source

De novo assembly and single-molecule study of kinetochore-microtubule interactions. [PDF]

Front Cell Dev Biol
Larson JD, Worst LR, Asbury CL.
europepmc   +1 more source

Artificial Catch Bonds: From Molecular Design to Network Mechanics

ChemSystemsChem, Volume 8, Issue 5, September 2026.
Catch bonds strengthen rather than weaken under force. This review follows the discovery and development of our understanding of this counterintuitive phenomenon, from the molecular mechanisms that produce it to the design rules for engineering it in DNA, proteins, and polymers, and on to the collective network mechanics enabling materials that stiffen
Hengfeng Jiang, Micah Yang, Isaac T. S. Li   +2 more
wiley   +1 more source

Uncovering Prognostic Biomarkers Underlying Hepatocellular Carcinoma Through Integrative Multi-Omics and a Network-Based Approach. [PDF]

Int J Mol Sci
Rahmani AH, Beg A, Sarwar T, Khan AA.
europepmc   +1 more source

A high‐quality haplotype‐resolved genome of Pyrus calleryana provides insights into adaptive gene families

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract Callery pear (Pyrus calleryana) is a deciduous species native to East Asia with notable ornamental and ecological value, but the genomic resources for this species remain limited. Here, we report the first haplotype‐resolved, chromosome‐scale genome of P. calleryana.
Xiaogang Dai, Xiaoyue Yang, Changci Jiang, Lizhen Huang, Fangping Li, Zhuangwei Hou, Fenghou Shi, Zefu Wang, Wenjie Yang, Yongbao Shen   +9 more
wiley   +1 more source

Augmented CENH3 loading is accompanied by transcriptional and epigenetic reprogramming at rice centromeres during meiosis. [PDF]

Genome Biol
Cao L, Zhao Y, You H, Liu H, Wang B, Run Y, Yang H, Wen M, Chen J, Zhao P, Shen Y, Li Y, Zhang W, Cheng Z.   +13 more
europepmc   +1 more source

The Secret (Mitotic) Life of Clathrin

Traffic, Volume 27, Issue 3, September 2026.
A perspective on the function of clathrin at the mitotic spindle during cell division. ABSTRACT The discovery of clathrin was a foundational event in membrane traffic research. Its identification as the major protein component of the coat that surrounds endocytic vesicles kickstarted the biochemical and molecular characterization of endocytosis. During
Stephen J. Royle
wiley   +1 more source

Structural and Functional Insights Into (S)‐5′‐C‐Guanidinopropyl Uridine‐Modified Oligonucleotides With 2′‐O‐Methyl and 2′‐Fluoro Substitutions for RNAi Therapeutics

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Novel (S)‐5′‐guanidinopropyl uridine analogs bearing 2′‐O‐methyl or 2′‐fluoro substitutions enhance nuclease resistance and mismatch discrimination while preserving A‐form RNA structure and potent RNAi activity. These modifications provide a promising strategy for improving the stability, specificity, and therapeutic potential of siRNA‐based medicines.
Sugahara Masaki, Elsayed M. Mahmoud, Shuichi Sakamoto, Yoshihito Ueno   +3 more
wiley   +1 more source

De Novo Complex Genomic Rearrangement Spanning 2q31.1 in a Proband With Congenital Malformations: Genotype–Phenotype Correlation and Development of a CGR Detection Pipeline

American Journal of Medical Genetics Part A, Volume 200, Issue 8, Page 1832-1841, August 2026.
ABSTRACT The 2q31 region is commonly associated with pathogenic alleles of the HOXD cluster leading to various clinical phenotypes related to skeletal development. We present a proband with tetralogy of Fallot and multiple congenital anomalies. Genomic variant screening including an in‐house CGR detection pipeline pairing genome sequencing (GS ...
Katherine Helle, Jesse D. Bengtsson, Mira Gandhi, Christopher M. Grochowski, Ming Yin Lun, Neha Sudhir, Shalini N. Jhangiani, Fritz J. Sedlazeck, Seema R. Lalani, Neil A. Hanchard, Claudia M. B. Carvalho   +10 more
wiley   +1 more source