Practice‐Changing Advances in Systemic Therapies Shaping the Landscape of Lung Cancer in 2025
Cancer Innovation, Volume 5, Issue 3, June 2026.This review synthesizes 2025 breakthroughs in systemic therapies of lung cancer, especially in targeted and immunotherapies, accelerating mortality decline across non‐small cell lung cancer and small cell lung cancer stages. ABSTRACT With the rapid advancement of molecular profiling and precision therapeutics, targeted and immunotherapeutic strategies ...
Zhenyu Zhou +3 more
wiley +1 more source
Outer kinetochore proteins form linear elements to regulate vesicle transport. [PDF]
J Cell SciKowaleski SJ +5 more
europepmc +1 more source
TTK Overexpression: A Negative Prognostic Biomarker in Anaplastic Thyroid Carcinoma
Cancer Medicine, Volume 15, Issue 6, June 2026.ABSTRACT Background Given threonine and tyrosine kinase (TTK)'s oncogenic role in various cancers and its understudied status in thyroid cancer, this study investigates TTK expression in thyroid lesions to assess its diagnostic and therapeutic potential. Methods We analyzed differential TTK expression levels using public datasets (n = 143) and clinical
Yan Guo +7 more
wiley +1 more source
A chromatin-associated pool of Aurora A controls kinetochore-microtubule attachments to ensure chromosome biorientation. [PDF]
Sci AdvMeaders JL +7 more
europepmc +1 more source
Cancer Medicine, Volume 15, Issue 6, June 2026.ABSTRACT Background Shugoshin proteins SGO1 and SGO2 regulate chromosome cohesion and segregation during mitosis and meiosis, and their aberrant expression is implicated in several cancers. However, the mechanistic involvement of these two proteins in papillary renal cell carcinoma (KIRP) and their contribution to immune evasion remains unclear ...
Han Fu +7 more
wiley +1 more source
Clinical Case Reports, Volume 14, Issue 6, June 2026.ABSTRACT Takayasu arteritis (TA) is a rare chronic granulomatous large‐vessel vasculitis predominantly affecting the aorta and its major branches, leading to stenosis, occlusion, or aneurysm formation. It typically presents in young women, though atypical cases can occur in older adults.
Chao Liu +6 more
wiley +1 more source
Using Yeast Two-Hybrid Screening and Structural Modeling to Identify Candidate Hrr25 Kinase Interactors at the Meiotic Kinetochore in <i>Saccharomyces cerevisiae</i>. [PDF]
Int J Mol SciAgarwal M, Chakraborty S, Ghosh SK.
europepmc +1 more source
Interaction Between Actin and Microtubules During Plant Development
Cytoskeleton, Volume 83, Issue 6, Page 328-336, June 2026.ABSTRACT The dynamic interaction between actin filaments (AFs) and microtubules (MTs) plays a crucial role in regulating key developmental and physiological processes in plant cells, particularly in the formation of specialized cell types with distinct shapes and functions, such as pollen tubes, trichomes, and leaf epidermal cells.
Zining Wu +3 more
wiley +1 more source
Keeping it centered: decoding the activities that regulate yeast histone H3 variant Cse4 and confine it to centromeres. [PDF]
Front Cell Dev BiolGreco M, Klim J, De Wulf P.
europepmc +1 more source
Cytoskeleton, Volume 83, Issue 6, Page 354-375, June 2026.ABSTRACT Of the three types of cytoskeleton known in animals—actin, microtubules, and intermediate filaments—only actin and microtubules exist in plants. Both play important roles in cellular shaping, organelle movement, organization of the endomembrane system, and cell signaling.
Norman R. Groves +3 more
wiley +1 more source