Results 161 to 170 of about 117,673 (373)

Two functionally distinct kinetochore pools of BubR1 ensure accurate chromosome segregation

Nature Communications, 2016
The BubR1/Bub3 complex is an important regulator of chromosome segregation as it facilitates proper kinetochore–microtubule interactions and is also an essential component of the spindle assembly checkpoint (SAC).
Gang Zhang, Blanca Lopez Mendez, G. Sedgwick, Jakob Nilsson   +3 more
semanticscholar   +1 more source

Titin Is Present in the Elastic Tethers That Connect Separating Anaphase Chromosomes in Crane‐Fly Spermatocytes

Cytoskeleton, EarlyView.
ABSTRACT Elastic tethers connect telomeres of separating chromosomes in anaphase of animal cells. Immunofluorescence staining of titin in crane‐fly spermatocytes, using 4 different antibodies, shows that the giant elastic protein titin seems to be a component of mitotic tethers: titin “strands” extend between separating chromosomes, connecting their ...
Demetra Economopoulos, Maral Janan, Martina Krüger, Aavo‐Valdur Mikelsaar, Arthur Forer, Rose Sheykhani   +5 more
wiley   +1 more source

Fin1-PP1 Helps Clear Spindle Assembly Checkpoint Protein Bub1 from Kinetochores in Anaphase

Cell Reports, 2016
Summary: The spindle assembly checkpoint (SAC) monitors chromosome attachment defects, and the assembly of SAC proteins at kinetochores is essential for its activation, but the SAC disassembly process remains unknown.
Michael Bokros, Curtis Gravenmier, Fengzhi Jin, Daniel Richmond, Yanchang Wang   +4 more
doaj   +1 more source

The CENP-F-like Proteins HCP-1 and HCP-2 Target CLASP to Kinetochores to Mediate Chromosome Segregation [PDF]

, 2005
Iain M. Cheeseman, Ian MacLeod, John R. Yates, Karen Oegema, Arshad Desai   +4 more
openalex   +1 more source

Decoding Polo-like kinase 1 signaling along the kinetochore-centromere axis

Nature Chemical Biology, 2016
Protein kinase signaling along the kinetochore-centromere axis is crucial to assure mitotic fidelity, yet its spatial coordination is obscure. Here, we examined how pools of human Polo-like kinase 1 (Plk1) within this axis control signaling events to ...
Robert F. Lera, Gregory K. Potts, Aussie Suzuki, James M. Johnson, E. Salmon, J. Coon, M. Burkard   +6 more
semanticscholar   +1 more source

PharmVar GeneFocus: NAT2—Genetic Variation and Updated Nomenclature

Clinical Pharmacology &Therapeutics, EarlyView.
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human N‐acetyltransferase 2 (NAT2) gene. NAT2 metabolizes several clinically used drugs including isoniazid, hydralazine, amifampridine, procainamide, and sulfonamides such as dapsone, and also some highly carcinogenic arylamines.
Georgia Papanikolaou, Estella S. Poloni, José A.G. Agúndez, Raquel L.F. Teixeira, Erin C. Boone, Adalberto Rezende Santos, Michelle Whirl‐Carrillo, Katrin Sangkuhl, Teri E. Klein, Mariam R. Habil, Giannoulis Fakis, Rodney F. Minchin, David W. Hein, Sotiria Boukouvala, Andrea Gaedigk   +14 more
wiley   +1 more source

Inferring the Forces Controlling Metaphase Kinetochore Oscillations by Reverse Engineering System Dynamics.

PLoS Computational Biology, 2015
Kinetochores are multi-protein complexes that mediate the physical coupling of sister chromatids to spindle microtubule bundles (called kinetochore (K)-fibres) from respective poles. These kinetochore-attached K-fibres generate pushing and pulling forces,
Jonathan W Armond, Edward F Harry, Andrew D McAinsh, Nigel J Burroughs   +3 more
doaj   +1 more source

Kinetochore or Centromere? [PDF]

Nature, 1939
IN his recent communication1, Dr. Mather seems to have no argument against the applicability of ‘kinetochore’. He sponsors “centromere” largely because it is used by a number of investigators. But I, for one, am not convinced that it is the “best term in use to-day”. To Dr. Mather ‘centromere’ may imply a visible particle, but to many it will connote a
openaire   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

A novel role for the CBF3 kinetochore–scaffold complex in regulating septin dynamics and cytokinesis [PDF]

, 2005
Amethyst Gillis, Scott C. Thomas, Scott D. Hansen, Kenneth B. Kaplan   +3 more
openalex   +1 more source