Results 181 to 190 of about 44,237 (280)

Saccharomyces cerevisiae Mub1, a substrate adaptor of E3 ubiquitin ligase Ubr2, modulates sensitivity to cell wall stressors through multiple transcription factors

The FEBS Journal, EarlyView.
We show that Mub1 links cell wall robustness with the ubiquitin‐proteasome system. As an adaptor protein of the E3 ubiquitin ligase Ubr2, it facilitates the ubiquitination of various transcription factors, including Mcm1 and Swi4. Yeasts evolved a complex regulatory programme to build and maintain their cell wall, the primary structure through which ...
Nada Šupljika, Antonia Paić, Ana Novačić, Tea Martinić Cezar, Béatrice Vallée, Renata Teparić, Igor Stuparević, Bojan Žunar   +7 more
wiley   +1 more source

Force transmission through the inner kinetochore is enhanced by centromeric DNA sequences. [PDF]

Elife
Miedlar E, Hamilton GE, Witus SR, Gonske SJ, Riffle M, Zelter A, Klevit RE, Asbury CL, Dimitrova YN, Davis TN.   +9 more
europepmc   +1 more source

A CRISPR‐Cas9‐based system for the dose‐dependent study of DNA double‐strand break sensing and repair

The FEBS Journal, EarlyView.
Using CRISPR‐Cas9, we engineered a genetic system allowing the dose‐dependent induction of a controllable number of DNA double‐strand breaks in Saccharomyces cerevisiae. The tool was used to study the kinetics of DNA break sensing and repair, including the spatial distribution of Tel1ATM kinase, which initiates the DNA damage response.
Morgane Auboiron, Jocelyn Coiffard, Sylvain Kumanski, Olivier Santt, Benjamin Pardo, María Moriel‐Carretero   +5 more
wiley   +1 more source

Stability and robustness of kinetochore dynamics under sudden perturbations and stochastic influences. [PDF]

Sci Rep
Mukhamedova F, Mukhamedov F.
europepmc   +1 more source

Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation [PDF]

, 2001
Bonnie J. Howell, B.F. McEwen, Julie C. Canman, David B. Hoffman, Emily M Farrar, C L Rieder, Edward D. Salmon   +6 more
openalex   +1 more source

Multi‐omic analysis identifies biological processes underlying progressive interstitial lung disease in systemic sclerosis

The FEBS Journal, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease, and lung complications (ILD) are the main cause of death. This study compared SSc patients with and without lung disease to healthy volunteers. We found increased inflammation, specific proteins, and higher triglyceride levels linked to lung disease progression. These findings suggest triglycerides
Selena Bouffette, Perrine Soret, Alice Cole, Emmanuel Nony, Pierre Barbier Saint Hilaire, Grégory Leclerc, Lamine Alaoui, Audrey Aussy, Isabelle Wehrle, Aude Le Gall, Mark Coulon, Marc Pallardy, Voon Ong, Jeanne Allinne, Philippe Moingeon, David Abraham, Christopher P. Denton   +16 more
wiley   +1 more source

Stu2 is required for plus-end directed chromosome transport along microtubules during metaphase in <i>Saccharomyces cerevisiae</i>. [PDF]

MicroPubl Biol
Torvi JR, Wong J, Drubin DG, Barnes G.
europepmc   +1 more source

Localization of Mad2 to Kinetochores Depends on Microtubule Attachment, Not Tension

, 1998
Jennifer Waters, Rey Huei Chen, Andrew W. Murray, E. D. Salmon   +3 more
openalex   +2 more sources

Merotelic Kinetochore Orientation Is a Major Mechanism of Aneuploidy in Mitotic Mammalian Tissue Cells [PDF]

, 2001
Daniela Cimini, Bonnie J. Howell, Paul S. Maddox, Alexey Khodjakov, Francesca Degrassi, Edward D. Salmon   +5 more
openalex   +1 more source

High‐throughput screening identifies a previously undescribed checkpoint controlling mitotic progression in response to DNA damage

The FEBS Journal, EarlyView.
DNA damage can cause mitotic delay to allow DNA repair to occur. However, the mechanism underlying this is unclear. Here, we show that in response to cells entering mitosis with DNA damage, SOD1 restrains PP2a activity via oxidation of cysteine residues at the active site. This leads to a reduction in PP2a activity at the mitotic kinetochore, resulting
Nan Li, Rachel Gatenby, Thomas Walne, Caroline Daye, Steven Watson, Priya Lata, Stephen Brown, Ruth Thompson   +7 more
wiley   +1 more source