Results 111 to 120 of about 6,100 (148)
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Kinin receptors: functional aspects
International Immunopharmacology, 2002Two types of receptors (B1R, B2R) for kinins are defined in mammalian species. Comparative experiments involving recombinant fusion proteins consisting of rabbit B1R or B2R fused to GFP-related proteins are exploited to study the regulation of the response to kinins at the receptor level.
François, Marceau +6 more
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Kallikrein and kinin receptor genes
Pharmacology & Therapeutics, 2000Recent evidence increasingly supports the view that kinins exercise an important regulatory control in inflammation and in the growth and proliferation of cancer cells. The induction of tissue kallikrein (TK) gene results in either increased or new expression of this protease, resulting in an increased capacity to form kinins.
R, Mahabeer, K D, Bhoola
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Molecular studies on kinin receptors
Canadian Journal of Physiology and Pharmacology, 1995We describe the results of functional studies on DNA clones encoding functional bradykinin receptors derived from human, rat, and mouse sources and including both genomic and complementary DNA clones. In both the Xenopus oocyte and the COS cell expression systems, the receptors from human and rat showed the pharmacological properties of B2receptors ...
M, Brown +4 more
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Nonpeptide antagonists for kinin receptors
Regulatory Peptides, 1999Kinins are a family of small peptides acting as mediators of inflammation and pain in the peripheral and central nervous system. The two main 'kinins' in mammals are the nonapeptide bradykinin (BK, Arg1-Pro2-Pro3-Gly4-Phe5-Ser6-Pro7-Phe8-Arg9) and the decapeptide kallidin (KD, [Lys0]-BK, Lys1-Arg2-Pro3-Pro4-Gly5-Phe6-Ser7-Pro8-Phe9- Arg10).
M, Altamura +3 more
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Kinins, Receptors, Antagonists
1986Kinins are potent myotropic agents acting on a variety of smooth muscle preparations: isolated arteries, veins, intestines, tracheae, urinary bladders, uteri, etc. In these tissues, kinins activate at least two different receptor types, B1 and B2. B1 and B2 receptors for kinins have been identified by measuring the order of potency of agonists and the ...
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Kinin receptors in cultured rat microglia
Neurochemistry International, 2004Kinins are produced and act at the site of injury and inflammation in various tissues. They are likely to initiate a particular cascade of inflammatory events, which evokes physiological and pathophysiological responses including an increase in blood flow and plasma leakage.
Mami, Noda +6 more
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Biochemical and Molecular Pharmacology of Kinin Receptors
Annual Review of Pharmacology and Toxicology, 1992Bradykinin (BK; Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg) is a potent in flammatory peptide whose generation in tissues and body fluids elicits numer ous responses including vasodilation, edema, smooth muscle spasm, as well as pain and hyperalgesia via stimulation of Cand A-fibers.
S G, Farmer, R M, Burch
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Kinin Receptors in Vascular Biology and Pathology
Current Vascular Pharmacology, 2014Endogenous kinins are important vasoactive peptides whose effects are mediated by two G-Protein-coupled receptors (R), named B2R (constitutive) and B1R (inducible). They are involved in vascular homeostasis, ischemic pre- and post- conditioning, but also in cardiovascular diseases.
Rejean, Couture +2 more
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Pharmacology of kinin receptors: recent developments
Canadian Journal of Physiology and Pharmacology, 1995Fifteen years after the classification of kinin receptors into B1and B2, both receptors have been shown to differ between species. New receptor types have been proposed and named B3, B4, and B5. However, it is not established whether different pharmacologic profiles describing B2receptors in various species are indicative of different receptor types or
D, Regoli, F, Gobeil
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Adrenergic Receptors and Kinins
1968Epinephrine, as it is known, exhibits a diphasic effect on the blood pressure. In hypertensive patients, if small amounts of epinephrine are used, the hypotension is more evident than hypertension (Greppi 1932, Goldenberger et al. 1948). The effect of nor-adrenaline is simply monophasic.
F. Sicuteri +4 more
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