Results 121 to 130 of about 6,100 (148)

Targeting Kinin Receptors for the Treatment of Neurological Diseases

Current Pharmaceutical Design, 2005
Kinins (bradykinin, kallidin and their active metabolites) are peptide autacoids with established functions in cardiovascular homeostasis, contraction and relaxation of smooth muscles, inflammation and nociception. They are believed to play a role in disease states like asthma, allergies, rheumatoid arthritis, cancer, diabetes, endotoxic and pancreatic
RODI, Donata, COUTURE R, ONGALI B, SIMONATO, Michele   +3 more
openaire   +2 more sources

Kinin receptors: Key regulators of autoimmunity

Autoimmunity Reviews, 2017
The central function of the immune system is to protect the host from environmental agents such as microbes or chemicals, thereby preserving the integrity of the body, and preventing the onset of illness and infection. Moreover, the immune system is constantly challenged to discriminate self vs.
openaire   +2 more sources

Biological activities of photoaffinity labeling analogs of kinins and their irreversible effects on kinin receptors

Journal of Medicinal Chemistry, 1981
Several analogues of bradykinin and [des-Arg9]bradykinin with potentially reactive groups have been tested for their biological activities. In these analogues, phenylalanine was replaced by the aromatic amino acid (4'-nitro)Phe, (4'-amino)Phe, (4'-azido)Phe, and (4'-diazonium)Phe, as well as with other residues. [Des-Arg9]bradykinin and the octapeptide
E, Escher, E, Laczkó, G, Guillemette, D, Regoli   +3 more
openaire   +2 more sources

Activation of Sensory Nerves by Kinins: Pharmacologic Tools for Studying Kinin Receptors

1991
Bradykinin and kallidin are released in blood and tissues by several stimuli and produce a variety of local effects by acting as autacoids. Some of these effects appear to be initiated by stimulation of afferent fibers and produce tissue responses of reflex nature. Indeed, bradykinin has been shown to be the most active endogenous agent to produce pain
D, Regoli, N E, Rhaleb, N, Rouissi, C, Tousignant, D, Jukic, C, Drapeau   +5 more
openaire   +2 more sources

Role of kinin receptors in skin pigmentation

European Journal of Pharmacology
Previous studies have shown that all kinin system is constitutively expressed in the normal and inflamed skin, with a potential role in both physiological and pathological processes. However, the understanding regarding the involvement of the kinin system in skin pigmentation and pigmentation disorders remains incomplete.
Juliana de Cassia Pinto Ferreira, Bruna Silva Soley, Priscila Lucia Pawloski, Camila Guimarães Moreira, João Bosco Pesquero, Michael Bader, João Batista Calixto, Daniela Almeida Cabrini, Michel Fleith Otuki   +8 more
openaire   +2 more sources

The B1 Receptors for Kinins

Pharmacological Reviews, 1998
F, Marceau, J F, Hess, D R, Bachvarov
openaire   +2 more sources

Kinin Receptors

2013
Sébastien Talbot, James Chi-Jen Lin, Réjean Couture   +2 more
openaire   +1 more source

The role of kinin receptors in cancer and therapeutic opportunities

Cancer Letters, 2014
Chammas R, Pierre Sirois
exaly  

Targeted deletion of B 2-kinin receptors protects against the development of diabetic nephropathy

American Journal of Physiology - Renal Physiology, 2007
Stuart Lipsitz
exaly  

Kallikreins, kininogens and kinin receptors on circulating and synovial fluid neutrophils: role in kinin generation in rheumatoid arthritis

Rheumatology, 2009
Odette Shaw, Kanti D Bhoola, Philip J Thompson   +2 more
exaly