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Trichocystatin-2 from <i>Trichomonas vaginalis</i>: role of N-terminal cysteines in aggregation, protease inhibition, and trichomonal cysteine protease-dependent cytotoxicity on HeLa cells. [PDF]
Front ParasitolAranda-Chan V +5 more
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Kininogens, Kinins and Kinships
Thrombosis and Haemostasis, 1989This article reviews most recent developments in the field of the multifunctional kininogens which are involved in major physiologic systems such as the blood coagulation cascade, the inflammatory reaction, the inhibitor defense mechanism, and the acute phase response.
Werner Müller-Esterl
exaly +3 more sources
The Pharmacokinetics of the Kininogens
Thrombosis Research, 1998Recent evidence has shown that plasma high molecular weight kininogen and both kininogens have the ability to modulate prekallikrein activation and thrombin-induced platelet activation, respectively. However, nothing is known about the plasma clearance and tissue distribution of these proteins.
A H, Schmaier +3 more
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Structure and functions of human kininogens
Trends in Pharmacological Sciences, 1991Evidence has accumulated over the past three decades implicating plasma kininogens in numerous inflammatory processes. Delineation of the detailed biochemistry and, more recently, the molecular biology of the human kininogens has resulted in a deeper understanding of the structure-function correlations of the human kininogens. Studies of alterations of
R W Colman, Raúl A Dela Cadena
exaly +3 more sources
T-kininogen - the major plasma kininogen in rat adjuvant arthritis
Biochemical and Biophysical Research Communications, 1985Total kininogen in plasma of Freund's adjuvant treated rats increased 20-fold 7 days following the injection. Analysis of the kininogens demonstrated that increases in T-kininogen was the major reason for the rise in kininogen. High molecular weight and low molecular weight kininogens showed little or no change.
A, Barlas, H, Okamoto, L M, Greenbaum
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Hydroxylated Kininogens and Kinins
1992Hydroxyprolyl-3-bradykinin was identified in the digest of purified human high molecular weight (H) kininogen with plasma kallikrein. Hydroxyproline was not detected in the heavy and light chains portions of H kininogen, although they include three possible sites for hydroxylation of proline by proline hydroxylase.
H, Kato, K, Enjyoji
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Kininogen Deficiency in the Rat
1992The Brown Norway Katholiek (B/N-Ka) strain rat is the only animal strain that demonstrates deficiency in plasma HMW- and LMW-kininogens with a low level of prekallikrein. We developed an RIA for rat HMW-kininogen, LMW-kininogen, and T-kininogen, and using them measured these proteins in B/N-Ka and normal strain (B/N-Ki) rats.
S, Oh-ishi +3 more
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The Role of T-Kininogen and H and L Kininogens in Health and Disease
1989Until recently, the classical kallikrein-kinin system has been thought of as the major system in all species which is involved in the immediate cascade of bradykinin and other mediators in the inflammatory response. One historical fact that indicated that kallikrein may not be the liberator of kinins in all species was the published finding by Fasciola
L M, Greenbaum, C, Cho, A, Barlas
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Kininogen in Tumor-Bearing Mice
1989Three types of kininogens have been found so far in mammalian species which differ by molecular weight and susceptibility to the various kinino-genases. Two of them are present throughout the mammalian lineage, while the third type, termed T-kininogen, has been considered to be unique for the rat. Although kininogens have recently been identified to be
H, Okamoto +4 more
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