Results 111 to 120 of about 1,270 (154)
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A Preparation of Kininogen for the Assay of Kallikreins
Thrombosis and Haemostasis, 1966SummaryA method by which a kininogen preparation free of kallikrein and freed of inhibitors of the kininogenic system is described. The preparation can be used for the quantitative estimation of plasma or salivary kallikrein in the presence of active factors of the fibrinolytic system, since in such a preparation freed of kallikreinogen neither the ...
M, Malofiejew, K, Buluk, M, Czokalo
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Kinins and kininogen in endotoxin shock
Experientia, 1970Aucune quantite detectable de kinines ne fut trouvee apres administration d'endotoxine et l'on n'obtint pas de difference significative dans le contenu plasmatique en kininogenes apres l'injection. Nos resultats n'attribuent aux kinines aucune participation significative a l'hypotension du choc endotoxique.
O A, Carretero +2 more
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Rapid isolation of human kininogens
Thrombosis Research, 1987A rapid, two-step procedure is described for the isolation of both "high molecular weight" (H-) and "low molecular weight" (L-) plasma kininogens from a single sample of plasma. Affinity chromatography on carboxymethyl-papain-Sepharose is used, together with high-resolution anion exchange chromatography.
Johnson, David A. +3 more
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Control of Kininogen Gene Expression
1989Kininogens are precursor proteins of bradykinin that are widely distributed in mammalian blood plasma1-3. Kininogens are comprised of two distinct proteins, designated low molecular weight (LMW) and high molecular weight (HMW) kininogens. Both kininogens are single-chain glycoproteins and carry a bradykinin moiety in the interior of the polypeptide ...
S, Nakanishi +6 more
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[DNA analysis for the kininogen gene of patients with kininogen deficiency in Japan].
[Rinsho ketsueki] The Japanese journal of clinical hematology, 1990The kininogen (KGN) gene status was examined in 4 families with both high molecular weight (HMW) and low molecular weight (LMW) KGM deficiency and one family with only HMW-KGN deficiency reported in Japan. No abnormal HMW-KGN or LMW-KGN was detected in those with these deficiencies by immunoblot analysis using monoclonal antibodies (HKG-H12, HKG-L7 ...
H, Hayashi +5 more
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T-Kininogen, Processing and Functions
1992Studies are presented which indicate that T-kininogen, the acute phase kininogen of the rat, could be a healing protein because of its properties as a cysteine protease inhibitor. Evidence is also presented that mRNA of T-kininogen synthesis may be a function of interleukin 6 production.
L M, Greenbaum +4 more
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Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 1997
The ratio of kininogen that is substrate of plasma kallikrein to kininogen, which is not substrate of plasma kallikrein in canine plasma, was about 1:3.6 by differential assay of kininogens. When the plasma was gel-filtered through a column of Sephacryl S-300 superfine, two fractions, which released kinin by trypsin, were obtained.
H, Mashiko, H, Takahashi
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The ratio of kininogen that is substrate of plasma kallikrein to kininogen, which is not substrate of plasma kallikrein in canine plasma, was about 1:3.6 by differential assay of kininogens. When the plasma was gel-filtered through a column of Sephacryl S-300 superfine, two fractions, which released kinin by trypsin, were obtained.
H, Mashiko, H, Takahashi
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The Preparation of Human Kininogen
The Journal of Immunology, 1971Abstract Highly purified human plasma kininogen was detected functionally and antigenically in order to establish its electrophoretic mobility, isoelectric point and molecular weight. The effect of specific and nonspecific treatment upon these parameters was assessed and it is suggested that the several human kininogens may in fact ...
Jocelyn Spragg, K Frank Austen
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Cellular Localization of Human Kininogens
1992An immunocytochemical screening using polyclonal and monoclonal antikininogen antibodies was performed in various human tissues including blood cells. By comparing the spatial relationship between the cellular localizations of tissue kallikrein and kininogens it was evident that in some tissues both enzyme and substrate were present establishing a ...
C D, Figueroa +3 more
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Demonstration of high-molecular-weight kininogen in kininogen-deficient rat kidneys.
Journal of biochemistry, 1995Brown Norway Katholiek (B/N-Ka) is a mutant rat strain deficient in plasma high-molecular-weight (HK) and low-molecular-weight kininogen (LK). It has been reported that the deficiency, caused by defective secretion of HK and LK by the liver, is associated with a point mutation of alanine (163) to threonine in the common heavy chain.
T, Mimura +3 more
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