Results 101 to 110 of about 2,276,672 (229)

Astrocyte Regulation of Spinal Circuit Function

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
Spinal cord astrocytes exist as an additional component of the computational framework that governs both sensory perceptions and motor outputs (left). By integrating local synaptic activity together with signals that reflect whole‐body state (e.g., neuromodulators, immune signals, and vascular signals) into defined input states (Sn), astrocytes adapt ...
Mary Kaye Duff, Min Jun Li, Axel Nimmerjahn   +2 more
wiley   +1 more source

Potassium Channel KIR4.1-Specific Antibodies and Acquired Demyelinating Disease

Pediatric Neurology Briefs, 2014
Researchers at Technische Universitat, Munich, and other centers in Germany, studied the prevalence of KIR4.1-IgG by ELISA in 47 children with acquired demyelinating disease (ADD), in 22 with other neurologic diseases, 22 with autoimmune disease, and in 18 healthy controls.
J Gordon Millichap, John J Millichap
openaire   +3 more sources

Mapping Satellite Glial Cell Heterogeneity Reveals Distinct Spatial Organization and Implies Functional Diversity in the Dorsal Root Ganglion

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Four distinct satellite glial cell subtypes are identified in mouse dorsal root ganglia using single‐cell RNA sequencing and spatial validation. These subtypes show unique marker profiles and anatomical distributions. Human dorsal root ganglia display layered perisomatic organization with differential marker expression.
Ole Andreas Ahlgreen, Mads Würgler Hansen, Jonas Baake, Thomas Engelbrecht Hybel, Rachele Rossi, Xin Lai, Ishwarya Sankaranarayanan, Johanne Amalie Pold, Lin Lin, Line Reinert, Søren Riis Paludan, Theodore John Price, Lone Tjener Pallesen, Christian Bjerggaard Vægter   +13 more
wiley   +1 more source

It's All about Timing: The Involvement of Kir4.1 Channel Regulation in Acute Ischemic Stroke Pathology

Frontiers in Cellular Neuroscience, 2018
An acute ischemic stroke is characterized by the presence of a blood clot that limits blood flow to the brain resulting in subsequent neuronal loss.
Meagan Milton, Patrice D. Smith
doaj   +1 more source

The Impact of Aquaporin‐4 Deletion on K+‐Induced Astrocytic Swelling Depends on K+ Concentration

Glia, Volume 74, Issue 1, January 2026.
Swelling due to 10 mM [K+]o is reduced in astrocytes devoid of aquaporin‐4, while there is no difference between genotypes when exposed to 50 mM [K+]o. The two [K+]o concentrations induce distinct astrocytic Ca2+ signaling in the two genotypes pointing to a possible mechanistic basis of the differences observed. ABSTRACT Astrocytes swell in response to
Cecilie Bugge Bakketun, Lena Catherine Roth, Daniel Marelius Bjørnstad, Ole Petter Ottersen, Vidar Jensen, Rune Enger   +5 more
wiley   +1 more source

Seizures and disturbed brain potassium dynamics in the leukodystrophy megalencephalic leukoencephalopathy with subcortical cysts [PDF]

, 2018
OBJECTIVE: Loss of function of the astrocyte-specific protein MLC1 leads to the childhood-onset leukodystrophy "megalencephalic leukoencephalopathy with subcortical cysts" (MLC).
Boschert, U, Brouwers, E, Bugiani, M, Dubey, M, Hamilton, EMC, Koch, H, Kole, MHP, Mansvelder, HD, Min, R, Stiedl, O, van der Knaap, MS, Wykes, RC   +11 more
core   +1 more source

Heterozygous KCNJ10 variants affecting Kir4.1 channel cause paroxysmal kinesigenic dyskinesia

, 2023
Abstract Background Paroxysmal kinesigenic dyskinesia is the representative form of paroxysmal dyskinesia, and its mechanism is unclear. Although paroxysmal kinesigenic dyskinesia is mostly attributed to genetic factors, more than 60% of paroxysmal kinesigenic dyskinesia cases are of uncertain mutations.
Xiaojun Huang, Xin Fu, Jingying Wu, Xiaoqi Hong, Ziyi Li, Lan Zheng, Qing Liu, Shendi Chen, Beisha Tang, Yuwu Zhao, Xiaorong Liu, Xunhua Li, Xiaoli Liu, Zaiwei Zhou, Li Wu, Kan Fang, Ping Zhong, Mei Zhang, Xinghua Luan, Wotu Tian, Xiaoping Tong, Li Cao   +21 more
openaire   +1 more source

Astrocytic Chromatin Remodeler ATRX Gates Hippocampal Memory Consolidation Through Metabolic and Synaptic Regulation

Glia, Volume 74, Issue 1, January 2026.
Astrocytic ATRX loss causes non‐cell‐autonomous neuronal hyperexcitability. Inducing ATRX deficiency in astrocytes causes selective long‐term memory deficits. Dynamic transcriptomic changes reveal metabolic and synaptic pathway dysregulation. ABSTRACT Astrocytes are increasingly recognized as active regulators of synaptic transmission and memory, yet ...
Miguel A. Pena‐Ortiz, Julia K. Sunstrum, Alireza Ghahramani, Haley McConkey, Vanessa Dumeaux, Wataru Inoue, Nathalie G. Bérubé   +6 more
wiley   +1 more source

Tertiary lymphoid structure‐related RNA indicator as metastasis risk factor in nasopharyngeal carcinoma

Clinical and Translational Medicine, Volume 15, Issue 12, December 2025.
We established a robust predictive model for nasopharyngeal carcinoma (NPC) distant metastasis using RNA markers. When combined with clinical parameters, our RNA‐based risk score significantly improved the area under the curve to 90.4%. This study revealed that tertiary lymphoid structure formation may be associated with lower NPC metastasis risk after
Zhaozheng Hou, Ping Feng, Chi‐Leung Chiang, Kazi Anisha Islam, Songran Liu, Ying Wang, Yingpei Zhang, Michael King‐Yung Chung, Ngar‐Woon Kam, Zilu Huang, Victor Ho‐Fun Lee, Anne Wing‐Mui Lee, Dora Lai‐Wan Kwong, Wai Tong Ng, Jason Wing Hon Wong, Yunfei Xia, Wei Dai   +16 more
wiley   +1 more source

Role of Kir4.1 Channel in Auditory Function: Impact on Endocochlear Potential and Hearing Loss

Applied Sciences
Hearing loss can result from impairments in structures that support endocochlear potential, as they play a crucial role in the transduction and transmission of auditory waves. This aspect has been the subject of several studies to date.
Silvia Fracaro, Filippo Hellies, Gino Marioni, Davide Brotto, Sebastiano Franchella, Elisabetta Zanoletti, Giovanna Albertin, Laura Astolfi   +7 more
doaj   +1 more source