Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BK-beta-1-subunit leads to progressive hearing loss [PDF]
, 2005 The large conductance voltage- and Ca2+-activated potassium (BK) channel has been suggested to play an important role in the signal transduction process of cochlear inner hair cells.
Arntz, Claudia +18 more
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Development of the stria vascularis and potassium regulation in the human fetal cochlea : insights into hereditary sensorineural hearing loss [PDF]
, 2015 Sensorineural hearing loss (SNHL) is one of the most common congenital disorders in humans, afflicting one in every thousand newborns. The majority is of heritable origin and can be divided in syndromic and nonsyndromic forms. Knowledge of the expression
Chuva de Sousa Lopes, Susana Marina +5 more
core +2 more sources
Heterogeneity of Kir4.1 channel expression in glia revealed by mouse transgenesis [PDF]
Glia, 2009 AbstractThe weakly inwardly rectifying K+channel Kir4.1 is found in many glial cells including astrocytes. However, questions remain regarding the relative contribution of Kir4.1 to the resting K+conductance of mature astrocytes in situ. We employed a bacterial artificial chromosome transgenic approach in mice to visualize Kir4.1 expression in vivo ...
Xiaofang, Tang +2 more
openaire +2 more sources
Label‐Free Molecular Characterization of Protein Aggregates in Differentiated Astrocytes
Advanced Science, EarlyView.Mid‐infrared photothermal microscopy enables label‐free structural, molecular, and functional imaging of protein aggregates in astrocyte cells. The processes of astrocytes differentiated on a nanomaterial interface are characterized by α‐helical signatures combined with enhanced interfacial thermal resistance properties, while the cell soma of non ...
Panagis D. Samolis +9 more
wiley +1 more source
Advanced Science, EarlyView.Compared to untargeted therapy, the targeted nanocarrier, Angiopep‐2‐conjugated Lipid Nanoparticle (A‐LNP) loaded with TGN‐020 (TGN), selectively accumulated in stroke‐injured regions. It suppressed local aquaporin‐4 (AQP4) overexpression, thereby alleviating cerebral edema and hypoperfusion while preserving global glymphatic clearance.
Lei Jin +18 more
wiley +1 more source
Functional implication of Dp71 in osmoregulation and vascular permeability of the retina. [PDF]
PLoS ONE, 2009 Functional alterations of Müller cells, the principal glia of the retina, are an early hallmark of most retina diseases and contribute to their further progression.
Abdoulaye Sene +11 more
doaj +1 more source
CO2-dependent opening of an inwardly rectifying K+ channel [PDF]
, 2011 CO2 chemosensing is a vital function for the maintenance of life that helps to control acid–base balance. Most studies have reported that CO2 is measured via its proxy, pH. Here we report an inwardly rectifying channel, in outside-out excised patches
Dale, Nicholas, Huckstepp, Robert T. R.
core +2 more sources
Reduction of Kir4.1 channel activity in an oxidative stress‐related aging model
The FASEB Journal, 2021 Aging is a major risk factor for many chronic diseases that predisposes to impairment of cellular function via several mechanisms, including oxidative stress (OS) which exerts its action on plasma membrane and transport systems, affecting thus cell homeostasis. Among experimental aging models,
Remigante, A +8 more
openaire +2 more sources
Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases
BMEMat, EarlyView.This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou +6 more
wiley +1 more source
The emerging role of the inwardly rectifying K+ channels in autism spectrum disorders and epilepsy [PDF]
, 2011 Autism is a complex behavioral disorder that develops prior to age three years and is distinguished by high heritability. Many genes predisposing to autism spectrum disorders (ASDs) have been identified.
D’Adamo, Maria Cristina +7 more
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