Multi-trait GWAS of reaction norm parameters reveals environment-responsive loci influencing reproductive performance in heifers. [PDF]
Mota LFM +6 more
europepmc +1 more source
Comparative Analysis of Kisspeptin Levels and KISS1 Gene Polymorphism in Patients with Polycystic Ovary Syndrome (PCOS): Correlation with the Luteinizing Hormone-Follicle-Stimulating Hormone Ratio and PCOS-Associated Variables. [PDF]
Talukdar C +4 more
europepmc +1 more source
Hypothalamic control of puberty: from neuronal circuits to mechanisms for its metabolic regulation. [PDF]
Jimenez-Puyer M +4 more
europepmc +1 more source
Robust serotonin activation of the kisspeptin GnRH pulse generator in male and female mice.
Morris PG +7 more
europepmc +1 more source
Redundancy in Kiss1 Expression Safeguards Reproduction in the Mouse. [PDF]
Kisspeptin (Kiss1) signaling to GnRH neurons is widely acknowledged to be a prerequisite for puberty and reproduction. Animals lacking functional genes for either kisspeptin or its receptor exhibit low gonadotropin secretion and infertility. Paradoxically, a recent study reported that genetic ablation of nearly all Kiss1-expressing neurons (Kiss1 ...
Victor M Navarro +2 more
exaly +7 more sources
Mutations of the KISS1 Gene in Disorders of Puberty [PDF]
Abstract Context: Kisspeptin, encoded by the KISS1 gene, is a key stimulatory factor of GnRH secretion and puberty onset. Inactivating mutations of its receptor (KISS1R) cause isolated hypogonadotropic hypogonadism (IHH). A unique KISS1R-activating mutation was described in central precocious puberty (CPP). Objective:
Ana Claudia Latronico Xavier +2 more
exaly +4 more sources
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Evidence for the Existence of a Functional Kiss1/Kiss1 Receptor Pathway in Fish
Peptides, 2008In mammals, the Kiss1 receptor (Kiss1r) and its kisspeptin ligands are key factors regulating the onset of puberty. In fish, however, the mechanisms underlying the initiation of puberty are poorly understood and the role of the Kiss1r/kisspeptin pathway in this process has not been established.
Peter Kille, Ronny van Aerle, Anke Lange
exaly +3 more sources

