Results 171 to 180 of about 7,724 (208)
Mutations of the KISS1 Gene in Disorders of Puberty [PDF]
Journal of Clinical Endocrinology and Metabolism, 2010 Abstract Context: Kisspeptin, encoded by the KISS1 gene, is a key stimulatory factor of GnRH secretion and puberty onset. Inactivating mutations of its receptor (KISS1R) cause isolated hypogonadotropic hypogonadism (IHH). A unique KISS1R-activating mutation was described in central precocious puberty (CPP). Objective:
Leticia F G Silveira +2 more
exaly +4 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Evidence for the existence of a functional Kiss1/Kiss1 receptor pathway in fish
Peptides, 2008In mammals, the Kiss1 receptor (Kiss1r) and its kisspeptin ligands are key factors regulating the onset of puberty. In fish, however, the mechanisms underlying the initiation of puberty are poorly understood and the role of the Kiss1r/kisspeptin pathway in this process has not been established.
Ronny Van Aerle +2 more
exaly +3 more sources
The KiSS1/GPR54 system in fish
Peptides, 2009The KiSS1/GPR54 system has now been identified in non-mammalian vertebrates. Transcripts encoding for KiSS1 and its receptor, GPR54, have been isolated from a number of fish species. The expression of their genes was characterized in the context of temporal and spatial expression and in response to endocrine manipulations.
Abigaïl Elizur
exaly +4 more sources
Regulation of KiSS1 gene expression
Peptides, 2009Kisspeptins are the protein products encoded by KiSS1 gene, an important tumor metastatic suppressor and pivotal master hormone of puberty. Although KiSS1 gene is expressed in both central and peripheral tissues, the molecular mechanisms that determine the temporal and spatial expression of KiSS1 gene are not well understood.
Dali, Li, Weishi, Yu, Mingyao, Liu
openaire +2 more sources
KiSS1 in regulation of metastasis and response to antitumor drugs
Drug Resistance Updates, 2019Metastatic dissemination of tumor cells represents a major obstacle towards cancer cure. Tumor cells with metastatic capacity are often resistant to chemotherapy. Experimental efforts revealed that the metastatic cascade is a complex process that involves multiple positive and negative regulators.
Cristina Corno, Paola Perego
exaly +3 more sources
KISS1 in metastatic cancer research and treatment: potential and paradoxes
Cancer and Metastasis Reviews, 2020 The significance of KISS1 goes beyond its original discovery as a metastasis suppressor. Its function as a neuropeptide involved in diverse physiologic processes is more well studied. Enthusiasm regarding KISS1 has cumulated in clinical trials in multiple fields related to reproduction and metabolism. But its cancer therapeutic space is unsettled. This
Thuc Ly +2 more
exaly +4 more sources
KISS1 metastasis suppression and emergent pathways
Clinical & Experimental Metastasis, 2003Metastatic disease is the most critical impediment to cancer patient survival. However, comparatively little is known concerning the intricate pathways which govern the complex phenotypes associated with metastasis. The KISS1 metastasis suppressor gene inhibits metastasis in both in vivo melanoma and breast carcinoma models.
John F, Harms +2 more
openaire +2 more sources
KISS1 expression in human female adipose tissue
Archives of Gynecology and Obstetrics, 2012The current focus of kisspeptin research is an exploration of its key role in the hypothalamic control of human and animal fertility. Notwithstanding the importance of these studies, strong evidence exists that the gene encoding human kisspeptin, KISS1, is present in several peripheral sites, including the placenta. We also provided evidence that kiss1
Heather, Cockwell +5 more
openaire +2 more sources
Factors that regulate KiSS1 gene expression in the hippocampus
Brain Research, 2008Kisspeptin is a C-terminally amidated peptide encoded by the KiSS1 gene. The peptide and its receptor GPR54 are abundant in the hypothalamus and have been implicated as gatekeepers for the onset of puberty and the development of the reproductive system. Interestingly, GPR54 is also highly expressed in granule cells of the hippocampal dentate gyrus, and
Amy C, Arai, Nathane, Orwig
openaire +2 more sources
KISS1/KISS1R and Breast Cancer: Metastasis Promoter
Seminars in Reproductive Medicine, 2019AbstractKisspeptins (KPs), peptide products of the kisspeptin-1 (KISS1) gene, are the endogenous ligands for the KISS1 receptor, KISS1R, which is a G protein-coupled receptor. In many human tumors, KISS1 functions as a metastasis-suppressor gene and KISS1/KISS1R signaling has antimetastatic and tumor-suppressor roles. On the contrary, emerging evidence
Stephania, Guzman +4 more
openaire +2 more sources