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KISS1 expression in human female adipose tissue
Archives of Gynecology and Obstetrics, 2012The current focus of kisspeptin research is an exploration of its key role in the hypothalamic control of human and animal fertility. Notwithstanding the importance of these studies, strong evidence exists that the gene encoding human kisspeptin, KISS1, is present in several peripheral sites, including the placenta. We also provided evidence that kiss1
Heather, Cockwell +5 more
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118 Identification of KISS1 in the Domestic Cat
Reproduction, Fertility and Development, 2017In the last decade, a substantial dataset has been acquired to demonstrate the critical role of kisspeptins, a family of neuropeptides derived from the KISS1 gene, in the reproduction system of mammalian and non-mammalian species. The KISS1 gene initial product can be cleaved into a 54-amino acid protein, and further degrade from the N-terminus into ...
O. Amelkina +2 more
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A Clinicopathological Analysis of KISS1 and KISS1R Expression in Colorectal Cancer
Apmis, 2015 Kisspeptins, the products of the KISS1 gene have tumor suppressing and antimetastatic properties. We aimed to study KISS1 and KISS1R expression in colorectal cancer. We analyzed KISS1 and KISS1R expression using immunohistochemistry and image analysis in
Ioannis D Kostakis +2 more
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Estrogenic regulation of Kiss1 mRNA variants in Hatano rats
General and Comparative Endocrinology, 2013Differences in reproductive endocrinology distinguish Hatano high-avoidance animals (HAA) from low-avoidance animals (LAA). Compared to HAA rats, female LAA rats secrete low levels of basal luteinizing hormone (LH) and a reduced LH surge. To investigate the underlying cause of the differences between the two strains, levels of the following mRNAs were ...
Yasuyuki, Horii +6 more
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KISS1 and Kisspeptins Detection in Cell Lines
KISS1 belongs to the family of metastasis suppressor genes. However, its role is not limited to blocking cancer metastasis. KISS1 and its by-product kisspeptins (KP) are important players in regulating the reproductive axis in different species and have new roles in controlling physiological balance and social behaviors.openaire +2 more sources
The Role of KISS1 in Melanoma Metastasis Suppression
2005Among neoplasms, the severity and relevance of metastasis is perhaps most striking in the case of melanoma where surgical resection would conduce cure if not for the subsequent complications of distant metastatic foci. Compounding this notion are statistics revealing that the number of cases of malignant melanoma have doubled each of the last four ...
John F. Harms, Danny R. Welch
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The role of Kiss1 neurons in regulating metabolism and energy balance
PeptidesHypothalamic kisspeptin, encoded by the Kiss1 gene, serves as an important regulator of the reproductive axis and sexual maturation. Since reproductive physiology is tightly coupled to metabolic cues, metabolic status exerts significant influence on puberty and fertility. Emerging evidence identifies kisspeptin signaling as a key determinant of central
Lingyu Sun, Ruidong Gao, Jing Chen
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