Results 171 to 180 of about 8,330 (205)

Regulation of KiSS1 gene expression

Peptides, 2009
Kisspeptins are the protein products encoded by KiSS1 gene, an important tumor metastatic suppressor and pivotal master hormone of puberty. Although KiSS1 gene is expressed in both central and peripheral tissues, the molecular mechanisms that determine the temporal and spatial expression of KiSS1 gene are not well understood.
Dali, Li, Weishi, Yu, Mingyao, Liu
openaire   +2 more sources

Astrocytes promote progression of breast cancer metastases to the brain via a KISS1-mediated autophagy

Autophagy, 2017
Formation of metastases, also known as cancer dissemination, is an important stage of breast cancer (BrCa) development. KISS1 expression is associated with inhibition of metastases development.
Charles Cobbs, Anton Borovjagin, Z G Kadagidze   +2 more
exaly   +3 more sources

KiSS1 in regulation of metastasis and response to antitumor drugs

Drug Resistance Updates, 2019
Metastatic dissemination of tumor cells represents a major obstacle towards cancer cure. Tumor cells with metastatic capacity are often resistant to chemotherapy. Experimental efforts revealed that the metastatic cascade is a complex process that involves multiple positive and negative regulators.
Paola Perego, Cristina Corno
exaly   +3 more sources

Factors that regulate KiSS1 gene expression in the hippocampus

Brain Research, 2008
Kisspeptin is a C-terminally amidated peptide encoded by the KiSS1 gene. The peptide and its receptor GPR54 are abundant in the hypothalamus and have been implicated as gatekeepers for the onset of puberty and the development of the reproductive system. Interestingly, GPR54 is also highly expressed in granule cells of the hippocampal dentate gyrus, and
Amy C, Arai, Nathane, Orwig
openaire   +2 more sources

KISS1 expression in human female adipose tissue

Archives of Gynecology and Obstetrics, 2012
The current focus of kisspeptin research is an exploration of its key role in the hypothalamic control of human and animal fertility. Notwithstanding the importance of these studies, strong evidence exists that the gene encoding human kisspeptin, KISS1, is present in several peripheral sites, including the placenta. We also provided evidence that kiss1
Heather, Cockwell, Diane A, Wilkinson, Renda, Bouzayen, Syed A, Imran, Russell, Brown, Michael, Wilkinson   +5 more
openaire   +2 more sources

KISS1/KISS1R and Breast Cancer: Metastasis Promoter

Seminars in Reproductive Medicine, 2019
AbstractKisspeptins (KPs), peptide products of the kisspeptin-1 (KISS1) gene, are the endogenous ligands for the KISS1 receptor, KISS1R, which is a G protein-coupled receptor. In many human tumors, KISS1 functions as a metastasis-suppressor gene and KISS1/KISS1R signaling has antimetastatic and tumor-suppressor roles. On the contrary, emerging evidence
Stephania, Guzman, Muriel, Brackstone, Frederic, Wondisford, Andy V, Babwah, Moshmi, Bhattacharya   +4 more
openaire   +2 more sources

118 Identification of KISS1 in the Domestic Cat

Reproduction, Fertility and Development, 2017
In the last decade, a substantial dataset has been acquired to demonstrate the critical role of kisspeptins, a family of neuropeptides derived from the KISS1 gene, in the reproduction system of mammalian and non-mammalian species. The KISS1 gene initial product can be cleaved into a 54-amino acid protein, and further degrade from the N-terminus into ...
O. Amelkina, P. Tanyapanyachon, K. Chatdarong   +2 more
openaire   +1 more source

KiSS1 Suppresses Metastasis in Human Ovarian Cancer via Inhibition of Protein Kinase C Alpha

Clinical and Experimental Metastasis, 2005
Metastasis is a vital target for cancer treatment, since the majority of cancer patients die from metastatic, rather than the primary disease. KiSS1 has been identified as a metastasis suppressor gene in melanoma and breast carcinomas.
Michael Berk, Lisam Shanjukumar Singh, Berk Michael   +2 more
exaly   +1 more source

Estrogenic regulation of Kiss1 mRNA variants in Hatano rats

General and Comparative Endocrinology, 2013
Differences in reproductive endocrinology distinguish Hatano high-avoidance animals (HAA) from low-avoidance animals (LAA). Compared to HAA rats, female LAA rats secrete low levels of basal luteinizing hormone (LH) and a reduced LH surge. To investigate the underlying cause of the differences between the two strains, levels of the following mRNAs were ...
Yasuyuki, Horii, Sandun L, Dalpatadu, Tomoko, Soga, Ryo, Ohta, Gen, Watanabe, Kazuyoshi, Taya, Ishwar S, Parhar   +6 more
openaire   +2 more sources

Potent effect of KISS1-54 DNA vaccine compared with KISS1-10 DNA vaccine in inhibiting the fertility of female rats

Vaccine, 2018
Most studies on immunocastration currently focused on male animals. However, immunization of male animals does not completely inhibit sexual behavior and fertility. This study aimed to compare the immunocastration effect of KISS1 DNA vaccines encoding different lengths of kisspeptins in female rats for effective castration effects on both male and ...
Yanguo Han, Xiaoli Peng, Kai Li, Xunping Jiang, Guiqiong Liu, Liguo Yang, Caiyou Liang, Yuhetian Zhao, Yongjie Huang, Guangxin E, Yongju Zhao, Yongfu Huang   +11 more
openaire   +2 more sources