Results 161 to 170 of about 8,330 (205)
Integrating Models to Decode the GnRH Pulse Generator
Nechyporenko K +5 more
europepmc +1 more source
Mutations of the KISS1 Gene in Disorders of Puberty [PDF]
Journal of Clinical Endocrinology and Metabolism, 2010 Abstract Context: Kisspeptin, encoded by the KISS1 gene, is a key stimulatory factor of GnRH secretion and puberty onset. Inactivating mutations of its receptor (KISS1R) cause isolated hypogonadotropic hypogonadism (IHH). A unique KISS1R-activating mutation was described in central precocious puberty (CPP). Objective:
Ana Claudia Latronico +2 more
exaly +4 more sources
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Evidence for the existence of a functional Kiss1/Kiss1 receptor pathway in fish
Peptides, 2008In mammals, the Kiss1 receptor (Kiss1r) and its kisspeptin ligands are key factors regulating the onset of puberty. In fish, however, the mechanisms underlying the initiation of puberty are poorly understood and the role of the Kiss1r/kisspeptin pathway in this process has not been established.
Peter Kille +2 more
exaly +3 more sources
The KiSS1/GPR54 system in fish
Peptides, 2009The KiSS1/GPR54 system has now been identified in non-mammalian vertebrates. Transcripts encoding for KiSS1 and its receptor, GPR54, have been isolated from a number of fish species. The expression of their genes was characterized in the context of temporal and spatial expression and in response to endocrine manipulations.
Abigaïl Elizur
exaly +4 more sources
KISS1 expression in colorectal cancer
Apmis, 2013 Kisspeptins, the products of the KISS1 gene, are involved in cancer invasion, migration, metastasis and angiogenesis, while they induce apoptosis in various cancers. Herein, we studied KISS1 expression in colorectal cancer.
Ioannis Kostakis +2 more
exaly +1 more source
Regulation of Kiss1 Expression by Sex Steroids in the Amygdala of the Rat and Mouse
Endocrinology, 2011 Kisspeptin (encoded by the Kiss1 gene) is an important regulator of reproduction. In rodents, Kiss1 is expressed in two hypothalamic regions, the arcuate nucleus and anteroventral periventricular/ periventricular continuum, where it is regulated by sex ...
Alexander Kauffman +2 more
exaly +2 more sources
Minireview: The Epigenetic Modulation of KISS1 in Reproduction and Cancer [PDF]
International Journal of Environmental Research and Public Health, 2019 Epigenetics describes how both lifestyle and environment may affect human health through the modulation of genome functions and without any change to the DNA nucleotide sequence. The discovery of several epigenetic mechanisms and the possibility to deliver epigenetic marks in cells, gametes, and biological fluids has opened up new perspectives in the ...
Rosaria Meccariello +2 more
exaly +3 more sources