Results 121 to 130 of about 1,110,898 (202)

KISS1 gene analysis in patients with central pubertal disorders

, 2009
A kisspeptina, codificada pelo gene KISS1, é um neuropeptídeo crucial na regulação do início da puberdade. A kisspeptina estimula a secreção hipotalâmica do hormônio liberador de gonadotrofinas (GnRH) após se ligar ao seu receptor GPR54.
Letícia Ferreira Gontijo Silveira, Silveira, Letícia Ferreira Gontijo   +1 more
core   +1 more source

Physicochemically and Pharmacokinetically Stable Nonapeptide KISS1 Receptor Agonists with Highly Potent Testosterone-Suppressive Activity

, 2016
Modifications of metastin(45–54) produced peptide analogues with higher metabolic stability than metastin(45–54). N-terminally truncated nonapeptide 4 ([d-Tyr46,d-Pya­(4)47,azaGly51,Arg­(Me)53]­metastin­(46–54)) is a representative compound with both ...
Masaharu Nakayama (285382), Naoki Nishizawa (1773700), Kimiko Nishibori (1773715), Junko Ban (1773709), Michiko Terada (1773694), Tetsuya Ohtaki (1773685), Masami Kusaka (1773703), Chieko Kitada (1773679), Yukihiro Ikeda (1773718), Hisanori Matsui (1773688), Yoshihiro Takatsu (1773712), Taiji Asami (1773697), Shin-ichi Matsumoto (1773706), Naoki Tarui (1773682), Masashi Yamaguchi (276947), Atsushi Kiba (1773691), Atsuko Suzuki (124634)   +16 more
core   +1 more source

Estradiol elicits distinct firing patterns in arcuate nucleus kisspeptin neurons of females through altering ion channel conductances

eLife
Hypothalamic kisspeptin (Kiss1) neurons are vital for pubertal development and reproduction. Arcuate nucleus Kiss1 (Kiss1ARH) neurons are responsible for the pulsatile release of gonadotropin-releasing hormone (GnRH). In females, the behavior of Kiss1ARH
Jian Qiu, Margaritis Voliotis, Martha A Bosch, Xiao Feng Li, Larry S Zweifel, Krasimira Tsaneva-Atanasova, Kevin T O'Byrne, Oline K Rønnekleiv, Martin J Kelly   +8 more
doaj   +1 more source

Gonadotropin secretion and ovarian response of KISS1 knockout gilts treated with hormone analogs activating the hypothalamic–pituitary-gonadal axis

International audienceKisspeptin knockout (KISS1−/−) pigs exhibit hypogonadotropic hypogonadism. Hormone analogs targeting different levels of the hypothalamic–pituitary-gonad axis were used to characterize the secretion of reproductive hormones (LH ...
Ross, Caitlin, Beltramo, Massimiliano, Wilson, Kyle, Sonstegard, Tad, Wijesena, Hiruni, Cushman, Robert, Ahern, Daniel, Lents, Clay, Martins, Kyra, Flórez, Julio, White, Brett, Elsken, Dorothy   +11 more
core   +1 more source

UHRF1 negatively regulates KiSS1 expression.

, 2014
(A and B) KiSS1 expression level was assayed in RT4 cells overexpressed with UHRF1 or T24 cells treated with UHRF1-siRNA ...
Xin Zheng (104081), Jianwei Liu (163716), Xuetao Ma (637683), Yuhai Zhang (220277), Yu Zhang (12946), Zhen Huang (58276), Zhiyou Han (637682), Zhiqiang Zhu (637681)   +7 more
core   +1 more source

KISS1 expression in colorectal cancer

, 2013
Kisspeptins, the products of the KISS1 gene, are involved in cancer invasion, migration, metastasis and angiogenesis, while they induce apoptosis in various cancers. Herein, we studied KISS1 expression in colorectal cancer.
Kouraklis, G., Vaiopoulos, A.G., Patsouris, E., Kostakis, I.D., Koutsilieris, M., Agrogiannis, G., Mylona, E.   +6 more
core  

In-vitro effects of the urotensin-II peptide and its receptor antagonists on mcf-7 breast cancer cell line

Journal of the Egyptian National Cancer Institute
Background Urotensin-II is a powerful vasoconstrictor peptide. Both the peptide and its receptor, GPR14, affect central nervous system, cardiovascular system, and kidney functions.
Murat Olukman, Ezgi Olukman, Kutay Bulut, Burcu Bölük, Sunde Yılmaz Süslüer, Ayşe Erol   +5 more
doaj   +1 more source

Hypothalamic kisspeptin alleviates myasthenia gravis by regulating Th1/Th17/Treg balance through Inhibition of NF-κB signaling pathway

Journal of Neuroinflammation
Background Myasthenia gravis (MG) is an autoimmune disorder affecting neuromuscular junctions. While neuroendocrine-immune system dysfunction plays a crucial role in the development of autoimmune diseases, its involvement in MG remains largely unexplored.
Dan Lu, Linqi Liu, Wenjun Que, Rui Fan, Pingyang Ke, Jing Dong, Yaoqi Gan, Fei Xiao   +7 more
doaj   +1 more source

Gene Structure of the Kiss1 Receptor-2 () in the Atlantic Halibut: Insights into the Evolution and Regulation of Genes

, 2010
Kisspeptin and its receptor, Kiss1r, play an essential role in the control of the onset of puberty in vertebrates. We characterized the cDNA and genomic DNA encoding Kiss1r in Atlantic halibut (). The 1,146bp open reading frame predicts a 381 amino acid protein with high homology to the Kiss1r-2 of other teleost fish.
Mechaly, Alejandro S., Viñas, Jordi, Murphy, Colleen, Reith, Michael, Piferrer, Francesc   +4 more
openaire   +1 more source

Effects of Zearalenone on the Kiss1/GPR54 System and Related Genes Expression in the Hypothalamus and Pituitary Gland of Weaned Gilts. [PDF]

Toxins (Basel)
Yuan Z, Zhou M, Luan Y, Kong L, Yang W, Jiang S.   +5 more
europepmc   +1 more source