Results 161 to 170 of about 1,354,109 (194)

Evolutionary Insights Into the Steroid Sensitive kiss1 and kiss2 Neurons in the Vertebrate Brain [PDF]

Frontiers in Endocrinology, 2012
Kisspeptin was originally found as a peptide product of Kiss1gene and is now supposed to be an essential central regulator of reproduction in mammals. However, there is now a growing body of evidence to suggest that kiss2, the paralogous gene for kiss1 ...
Shinji Kanda, Yoshitaka Oka
exaly   +4 more sources

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Evidence for the Existence of a Functional Kiss1/Kiss1 Receptor Pathway in Fish

Peptides, 2008
In mammals, the Kiss1 receptor (Kiss1r) and its kisspeptin ligands are key factors regulating the onset of puberty. In fish, however, the mechanisms underlying the initiation of puberty are poorly understood and the role of the Kiss1r/kisspeptin pathway in this process has not been established.
Peter Kille, Ronny van Aerle, Anke Lange
exaly   +3 more sources

Redundancy in Kiss1 Expression Safeguards Reproduction in the Mouse.

Endocrinology, 2013
L’article original est publié par The Endocrine SocietyKisspeptin (Kiss1) signaling to GnRH neurons is widely acknowledged to be a prerequisite for puberty and reproduction.
Victor M Navarro, Elisenda Sanz, Donald K Clifton   +2 more
exaly   +2 more sources

KiSS1 And Its G-Protein-Coupled Receptor GPR54 in Cancer Development and Metastasis

Cancer and Metastasis Reviews, 2012
KiSS1 and its cognate G-protein-coupled receptor, GPR54, have diverse functions. While KiSS1 and GPR54 have been intensively studied in physiology, their role in cancer is still unclear. In cancer, KiSS1 and GPR54 have been known to suppress metastasis by inhibiting cancer cell motility.
Mingyao Liu, Dali Li, Sung-Gook Cho
exaly   +3 more sources

Estrogen Regulates KiSS1 Gene Expression Through Estrogen Receptor α and SP Protein Complexes [PDF]

Endocrinology, 2007
Kisspeptins are natural ligands of G protein-coupled receptor-54. Activation of KiSS1/G protein-coupled receptor-54 signaling pathways results in potent activation of the hypothalamus-pituitary-gonadal axis and initiates puberty. Recent data have shown that in female mice, KiSS1 is positively regulated by estradiol (E(2)) in the anteroventral ...
Dali Li, Sung-Gook Cho, Mingyao Liu
exaly   +3 more sources

KISS1 receptor is preferentially expressed in clinically non-functioning pituitary tumors

Pituitary, 2014
KISS1 is a metastasis suppressor gene involved in cancer biology. Given the high expression levels of KISS1 and KISS1R in the hypothalamus and the pituitary respectively, we hypothesized that this system could possibly affect tumor invasiveness and clinical behavior of pituitary tumors.Expression levels of KISS1 and KISS1R mRNA were evaluated by RT-PCR.
Yaron, M., Renner, U., Gilad, S., Stalla, G., Stern, N., Greenman, Y.   +5 more
openaire   +3 more sources

Abstract PS4-42: Kiss1, the kiss1 receptor (kiss1r) and the protein kinase c (pkc) family identifies patients with clinical outcome in clinical breast cancer

Cancer Research, 2021
Abstract Background: Kiss1, also known as Kisspeptin-1 and metastin, is a protein coded by the KISS1 gene (1). The receptor for KISS1, KISS1R (also known as G-protein coupled receptor 54 or GPR54 is coded by the KISS1R gene. Kiss1 and Kiss1R have been indicated in a number of pathophysiological conditions, including metabolic and ...
Tracey Amanda Martin, Edison Ke Ji, Amy G Jiang, Rishana Thayaparan, Robert E Mansel, Eleri Davies, Wen G Jiang   +6 more
openaire   +1 more source

The role of KiSS1/GPR54 receptor signaling pathway in cancer progression

2021
Metastasis accounts for 90% of cancer morbidity and mortality (Fares et al. 2020). Unfortunately, most of the existing anti-metastatic drugs exhibit very limited efficacy as well as show high toxicity levels in cancer patients. Thus, identifying key signaling pathways and molecules that relay and control metastasis remains a high priority to design ...
openaire   +1 more source

A new class of pentapeptide KISS1 receptor agonists with hypothalamic–pituitary–gonadal axis activation

Bioorganic & Medicinal Chemistry Letters, 2019
The kisspeptin (Kp, Kp-54, metastin)/KISS1R system plays crucial roles in regulating the secretion of gonadotropin-releasing hormone. Continuous administration of nonapeptide Kp analogs caused plasma testosterone depletion, whereas bolus administration caused strong plasma testosterone elevation in male rats.
Naoki Nishizawa, Taiji Asami, Kimiko Nishibori, Yoshihiro Takatsu, Atsuko Suzuki, Kazutaka Ushio, Shin-ichi Matsumoto, Yuji Shimizu, Masashi Yamaguchi, Masami Kusaka, Hisanori Matsui, Tetsuya Ohtaki, Chieko Kitada   +12 more
openaire   +2 more sources