Results 171 to 180 of about 1,110,898 (202)
KISS1 receptor is preferentially expressed in clinically non-functioning pituitary tumors
Pituitary, 2014 KISS1 is a metastasis suppressor gene involved in cancer biology. Given the high expression levels of KISS1 and KISS1R in the hypothalamus and the pituitary respectively, we hypothesized that this system could possibly affect tumor invasiveness and clinical behavior of pituitary tumors.Expression levels of KISS1 and KISS1R mRNA were evaluated by RT-PCR.
Marianna Yaron +2 more
exaly +5 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Evidence for the existence of a functional Kiss1/Kiss1 receptor pathway in fish
Peptides, 2008In mammals, the Kiss1 receptor (Kiss1r) and its kisspeptin ligands are key factors regulating the onset of puberty. In fish, however, the mechanisms underlying the initiation of puberty are poorly understood and the role of the Kiss1r/kisspeptin pathway in this process has not been established.
Peter Kille +2 more
exaly +3 more sources
Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54 [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2003 Hypogonadotropic hypogonadism is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function.
Jean-Claude Carel +2 more
exaly +5 more sources
KiSS1 and its G-protein-coupled receptor GPR54 in cancer development and metastasis
Cancer and Metastasis Reviews, 2012KiSS1 and its cognate G-protein-coupled receptor, GPR54, have diverse functions. While KiSS1 and GPR54 have been intensively studied in physiology, their role in cancer is still unclear. In cancer, KiSS1 and GPR54 have been known to suppress metastasis by inhibiting cancer cell motility.
Dali Li, Sung-Gook Cho, Stefan Siwko
exaly +3 more sources
Estrogen Regulates KiSS1 Gene Expression through Estrogen Receptor α and SP Protein Complexes [PDF]
Endocrinology, 2007 Kisspeptins are natural ligands of G protein-coupled receptor-54. Activation of KiSS1/G protein-coupled receptor-54 signaling pathways results in potent activation of the hypothalamus-pituitary-gonadal axis and initiates puberty. Recent data have shown that in female mice, KiSS1 is positively regulated by estradiol (E(2)) in the anteroventral ...
Xiushan Wu, Dali Li, Sung-Gook Cho
exaly +3 more sources
Estrogen Stimulation of Kiss1 Expression in the Medial Amygdala Involves Estrogen Receptor-α But Not Estrogen Receptor-β [PDF]
Endocrinology, 2016 The neuropeptide kisspeptin, encoded by Kiss1, regulates reproduction by stimulating GnRH secretion. Neurons synthesizing kisspeptin are predominantly located in the hypothalamic anteroventral periventricular (AVPV) and arcuate nuclei, but smaller kisspeptin neuronal populations also reside in extrahypothalamic brain regions, such as the medial ...
Alexander Kauffman +2 more
exaly +3 more sources
Regulation of Kiss1 Expression by Sex Steroids in the Amygdala of the Rat and Mouse
Endocrinology, 2011 Kisspeptin (encoded by the Kiss1 gene) is an important regulator of reproduction. In rodents, Kiss1 is expressed in two hypothalamic regions, the arcuate nucleus and anteroventral periventricular/ periventricular continuum, where it is regulated by sex ...
Alexander Kauffman +2 more
exaly +2 more sources
Cancer Research, 2021
Abstract Background: Kiss1, also known as Kisspeptin-1 and metastin, is a protein coded by the KISS1 gene (1). The receptor for KISS1, KISS1R (also known as G-protein coupled receptor 54 or GPR54 is coded by the KISS1R gene. Kiss1 and Kiss1R have been indicated in a number of pathophysiological conditions, including metabolic and ...
Tracey Amanda Martin +6 more
openaire +1 more source
Abstract Background: Kiss1, also known as Kisspeptin-1 and metastin, is a protein coded by the KISS1 gene (1). The receptor for KISS1, KISS1R (also known as G-protein coupled receptor 54 or GPR54 is coded by the KISS1R gene. Kiss1 and Kiss1R have been indicated in a number of pathophysiological conditions, including metabolic and ...
Tracey Amanda Martin +6 more
openaire +1 more source
The role of KiSS1/GPR54 receptor signaling pathway in cancer progression
2021Metastasis accounts for 90% of cancer morbidity and mortality (Fares et al. 2020). Unfortunately, most of the existing anti-metastatic drugs exhibit very limited efficacy as well as show high toxicity levels in cancer patients. Thus, identifying key signaling pathways and molecules that relay and control metastasis remains a high priority to design ...
openaire +1 more source