Results 171 to 180 of about 1,354,109 (194)

Increased Expression of KISS1 and KISS1 Receptor in Human Granulosa Lutein Cells-Potential Pathogenesis of Polycystic Ovary Syndrome.

Reproductive sciences (Thousand Oaks, Calif.), 2020
Kisspeptins are a family of neuropeptides that are essential for fertility. Recent experimental data suggest a putative role of kisspeptin signaling in the direct control of ovarian function. To explore the expression of KISS1 and KISS1 receptor (KISS1R) in human granulosa lutein cells and the potential role of KISS1/KISS1R system in the pathogenesis ...
Kai-Lun, Hu, Hongcui, Zhao, Zheying, Min, Yilei, He, Tianjie, Li, Xiumei, Zhen, Yun, Ren, Hsun-Ming, Chang, Yang, Yu, Rong, Li   +9 more
openaire   +1 more source

Deletion of GABAB receptors from Kiss1 cells affects glucose homeostasis without altering reproduction in male mice

American Journal of Physiology-Endocrinology and Metabolism, 2023
We developed a unique mouse lacking GABAB receptors specifically in Kiss1 cells to evaluate the impact on reproduction and metabolism. Knockout males showed a severe impact on glucose homeostasis, which worsened with aging. These results reinforce the proposed kisspeptin involvement in metabolic regulation and highlight the impact of GABA through ...
Noelia P. Di Giorgio, Marianne Bizzozzero-Hiriart, Pablo N. Surkin, Esteban Repetto, María M. Bonaventura, Florencia N. Tabares, Nadia S. Bourguignon, Ayelén Converti, Juan M. Riaño Gomez, Bernhard Bettler, Victoria Lux-Lantos   +10 more
openaire   +3 more sources

Physicochemically and Pharmacokinetically Stable Nonapeptide KISS1 Receptor Agonists with Highly Potent Testosterone-Suppressive Activity

Journal of Medicinal Chemistry, 2014
Modifications of metastin(45-54) produced peptide analogues with higher metabolic stability than metastin(45-54). N-terminally truncated nonapeptide 4 ([D-Tyr46,D-Pya(4)47,azaGly51,Arg(Me)53]metastin(46-54)) is a representative compound with both potent agonistic activity and metabolic stability.
Taiji, Asami, Naoki, Nishizawa, Hisanori, Matsui, Yoshihiro, Takatsu, Atsuko, Suzuki, Atsushi, Kiba, Michiko, Terada, Kimiko, Nishibori, Masaharu, Nakayama, Junko, Ban, Shin-ichi, Matsumoto, Naoki, Tarui, Yukihiro, Ikeda, Masashi, Yamaguchi, Masami, Kusaka, Tetsuya, Ohtaki, Chieko, Kitada   +16 more
openaire   +2 more sources

Polymorphism in KISS1 receptor gene was correlated with idiopathic male infertility in Guilan province, Iran

Gene Reports, 2017
Abstract Background Infertility is defined as the inability to get pregnant during 12 months or more regular unprotected sexual intercourse. Fertility is initiated by hormonal signals from brain to the gonads which lead to leakage of gonadotropin hormones.
Azadeh Poursharif, Sadeq Shabani, Hamid Reza Vaziri, Tooba Mirzapour   +3 more
openaire   +1 more source

GABAB Receptor Antagonism from Birth to Weaning Permanently Modifies Kiss1 Expression in the Hypothalamus and Gonads in Mice.

Neuroendocrinology, 2021
Fil: Bizzozzero Hiriart, Marianne. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental.
Bizzozzero Hiriart, Marianne, Di Giorgio, Noelia Paula, Libertun, Carlos, Lux, Victoria Adela R.   +3 more
openaire   +2 more sources

Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor.

Cancer research, 2002
G-protein-coupled receptors receive many different signals to activate different functions such as cellgrowth, proliferation, and migration. KiSS1 is a metastasis suppressor gene that has been shown to inhibit metastasis of human melanomas and breast carcinomas. The human KiSS1 gene encodes a COOH-terminally amidated active peptide, and this peptide is
Lewis Joe, Stafford, Chunzhi, Xia, Wenbin, Ma, Yi, Cai, Mingyao, Liu   +4 more
openaire   +1 more source

Systemic Therapy for Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Early Stage and Metastatic Breast Cancer

Ca-A Cancer Journal for Clinicians, 2023
Hope Rugo, Özge Gümüşay, Laura A Huppert   +2 more
exaly  

Critical Care Management of Chimeric Antigen Receptor T-Cell Therapy Recipients

Ca-A Cancer Journal for Clinicians, 2022
Sandrine Valadè, Peter Schellongowski, Alexander Shimabukuro-Vornhagen   +2 more
exaly  

KISS1 Receptor Knockout Exacerbate Airway Hyperreactivity and Remodeling in a Mouse Model of Allergic Asthma

C109. EVEN BETTER THAN THE REAL THING: ADVANCED MODELS OF LUNG DISEASE, 2023
N.S. Ambhore, P. Balraj, Y. Ramakrishnan, V. Sathish   +3 more
openaire   +1 more source

Chimeric Antigen Receptor T-Cell Therapy in Multiple Myeloma: A Comprehensive Review of Current Data and Implications for Clinical Practice

Ca-A Cancer Journal for Clinicians, 2023
Sagar Lonial, Rujul Parikh
exaly