Results 1 to 10 of about 21,387 (241)

Kisspeptin-10 Ameliorates Obesity-Diabetes with Diverse Effects on Ileal Enteroendocrine Cells and Pancreatic Islet Morphology in High-Fat Fed Female Mice. [PDF]

Biomolecules
Kisspeptin is a neuropeptide recognised for a pivotal role within the reproductive system, but potentially important endocrine metabolic effects are less well understood. We examined effects of twice-daily intraperitoneal administration of saline vehicle
Sridhar A, Khan D, Muthukumar R, Sampathkumar S, Irwin N, Flatt PR, Moffett RC.   +6 more
europepmc   +4 more sources

Kisspeptin signaling in astrocytes modulates the reproductive axis [PDF]

The Journal of Clinical Investigation
Reproduction is safeguarded by multiple, often cooperative, regulatory networks. Kisspeptin signaling, via KISS1R, plays a fundamental role in reproductive control, primarily by regulation of hypothalamic GnRH neurons.
Encarnacion Torres, Giuliana Pellegrino, Melissa Granados-Rodríguez, Antonio C. Fuentes-Fayos, Inmaculada Velasco, Adrian Coutteau-Robles, Amandine Legrand, Marya Shanabrough, Cecilia Perdices-Lopez, Silvia Leon, Shel H. Yeo, Stephen M. Manchishi, Maria J. Sánchez-Tapia, Victor M. Navarro, Rafael Pineda, Juan Roa, Frederick Naftolin, Jesús Argente, Raúl M. Luque, Julie A. Chowen, Tamas L. Horvath, Vincent Prevot, Ariane Sharif, William H. Colledge, Manuel Tena-Sempere, Antonio Romero-Ruiz   +25 more
doaj   +3 more sources

Kisspeptin regulates the proliferation and apoptosis of ovary granulosa cells in polycystic ovary syndrome by modulating the PI3K/AKT/ERK signalling pathway

BMC Women's Health, 2023
Highlights 1. Kisspeptin expression is decreased in ovaries of PCOS rat 2. Kisspeptin promotes proliferation and inhibits apoptosis of granulosa cells 3. Kisspeptin alleviates oxidative stress of granulosa cells 4.
Pingping Sun, Yuemin Zhang, Lilan Sun, Na Sun, Jinguang Wang, Huagang Ma   +5 more
doaj   +2 more sources

Current Perspectives on Kisspeptins Role in Behaviour [PDF]

Frontiers in Endocrinology, 2022
The neuropeptide kisspeptin is now well-established as the master regulator of the mammalian reproductive axis. Beyond the hypothalamus, kisspeptin and its cognate receptor are also extensively distributed in extra-hypothalamic brain regions.
Edouard G. Mills, Lisa Yang, Ali Abbara, Waljit S. Dhillo, Waljit S. Dhillo, Alexander N. Comninos, Alexander N. Comninos   +6 more
doaj   +2 more sources

The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction

Frontiers in Endocrinology, 2022
The discovery of kisspeptin as a critical central regulatory factor of GnRH release has given people a novel understanding of the neuroendocrine regulation in human reproduction.
Qinying Xie, Yafei Kang, Chenlu Zhang, Ye Xie, Chuxiong Wang, Jiang Liu, Caiqian Yu, Hu Zhao, Donghui Huang   +8 more
doaj   +2 more sources

TGF-β1 inhibits human trophoblast cell invasion by upregulating kisspeptin expression through ERK1/2 but not SMAD signaling pathway

Reproductive Biology and Endocrinology, 2022
Background Tightly regulation of extravillous cytotrophoblast (EVT) cell invasion is critical for the placentation and establishment of a successful pregnancy.
Lanlan Fang, Yang Yan, Yibo Gao, Ze Wu, Zhen Wang, Sizhu Yang, Jung-Chien Cheng, Ying-Pu Sun   +7 more
doaj   +2 more sources

Correlation between kisspeptin and biochemical markers in obese and non-obese women with polycystic ovary syndrome

Gynecological Endocrinology, 2023
Introduction The purpose of this study was to determine the association between kisspeptin levels and obesity in patients with polycystic ovary syndrome (PCOS) or in healthy controls and to explore the correlation between levels of kisspeptin and various
Meixiu Gao, Xinghua Tao, Qiong Zhang, Wenli He, Ting Zhao, Tao Yuan   +5 more
doaj   +2 more sources

Receptor deorphanization in an echinoderm reveals kisspeptin evolution and relationship with SALMFamide neuropeptides

BMC Biology, 2022
Background Kisspeptins are neuropeptides that regulate reproductive maturation in mammals via G-protein-coupled receptor-mediated stimulation of gonadotropin-releasing hormone secretion from the hypothalamus.
Nayeli Escudero Castelán, Dean C. Semmens, Luis Alfonso Yañez Guerra, Meet Zandawala, Mario dos Reis, Susan E. Slade, James H. Scrivens, Cleidiane G. Zampronio, Alexandra M. Jones, Olivier Mirabeau, Maurice R. Elphick   +10 more
doaj   +2 more sources

Central kisspeptin injection enhances food consumption in broiler chickens: role of opioidergic and dopaminergic receptors. [PDF]

Poult Sci
Kisspeptin, acting as both a neuropeptide and a hormone, known for its pivotal role in reproductive function and energy homeostasis, exerts multifaceted effects on central nervous system pathways involved in appetite regulation.
Zarei H, Radmehr M, Mohtasham A, Mehdipour M, Hasani K.   +4 more
europepmc   +2 more sources

Plasma kisspeptin levels are associated with insulin secretion in nondiabetic individuals. [PDF]

PLoS ONE, 2017
To evaluate if plasma kisspeptin concentrations are associated with insulin secretion, as suggested by recent in vitro studies, independently of confounders. 261 nondiabetic subjects were stratified into tertiles according to kisspeptin values.
Francesco Andreozzi, Gaia Chiara Mannino, Elettra Mancuso, Rosangela Spiga, Francesco Perticone, Giorgio Sesti   +5 more
doaj   +5 more sources