Kisspeptin-10 Ameliorates Obesity-Diabetes with Diverse Effects on Ileal Enteroendocrine Cells and Pancreatic Islet Morphology in High-Fat Fed Female Mice [PDF]
BiomoleculesKisspeptin is a neuropeptide recognised for a pivotal role within the reproductive system, but potentially important endocrine metabolic effects are less well understood. We examined effects of twice-daily intraperitoneal administration of saline vehicle
Ananyaa Sridhar +6 more
doaj +4 more sources
Aquaculture and Fisheries, 2022 Kisspeptin is a hormone involved in the neuroendocrine control of reproduction in fish. We hypothesized that kisspeptin stimulates oocyte maturation and modulates other reproductive hormones in zebrafish; and the gonadal kisspeptin system in zebrafish is
Azadeh Hatef +2 more
doaj +2 more sources
KNDy neurons as an indirect target of insulin-like growth factor-1. [PDF]
J NeuroendocrinolAbstract Neurons in the arcuate nucleus of the hypothalamus (ARH) that coexpress kisspeptin, neurokinin B, and dynorphin (KNDy neurons) are considered the gonadotropin‐releasing hormone (GnRH) pulse generator necessary for fertility. KNDy neurons are also metabolic sensors controlling the hypothalamic–pituitary‐gonadal (HPG) axis.
Silva JDN +8 more
europepmc +2 more sources
Kisspeptin/GPR54 System: What Do We Know About Its Role in Human Reproduction? [PDF]
Cellular Physiology and Biochemistry, 2018 Kisspeptin is involved in the control of human reproduction bridging the gap between the sex steroid levels and feedback mechanisms that control the gonadotropin releasing hormone (GnRH) secretion; however, studies considering this peptide and ...
Camila M. Trevisan +6 more
doaj +2 more sources
Central kisspeptin injection enhances food consumption in broiler chickens: role of opioidergic and dopaminergic receptors [PDF]
Poultry ScienceKisspeptin, acting as both a neuropeptide and a hormone, known for its pivotal role in reproductive function and energy homeostasis, exerts multifaceted effects on central nervous system pathways involved in appetite regulation.
Hamed Zarei +4 more
doaj +2 more sources
Plasma kisspeptin levels are associated with insulin secretion in nondiabetic individuals. [PDF]
PLoS ONE, 2017 To evaluate if plasma kisspeptin concentrations are associated with insulin secretion, as suggested by recent in vitro studies, independently of confounders. 261 nondiabetic subjects were stratified into tertiles according to kisspeptin values.
Francesco Andreozzi +5 more
doaj +5 more sources
Functional examination of novel kisspeptin phosphinic peptides. [PDF]
PLoS ONE, 2018 Kisspeptins acting on their cognate G protein-coupled receptor, kisspeptin receptor, play important roles in the suppression of cancer cell metastasis and regulation of the reproductive system, and therefore are important for therapeutic intervention ...
Xiaoyang Zhang +6 more
doaj +6 more sources
Emerging Perspectives on Gonadotropin Regulation in Vertebrates Revealed by the Discovery of FSH-RH in Teleosts. [PDF]
BioessaysRegarding pituitary gonadotropin regulation, recent studies have shown that in mammals, FSH and LH are regulated by a single GnRH (solo GnRH model), whereas in teleosts, they are regulated by CCK (FSH‐RH) and GnRH (LH‐RH), respectively (dual GnRH model).
Kayo D, Uehara SK, Royan MR, Kanda S.
europepmc +2 more sources
Reproductive hormone-dependent and -independent contributions to developmental changes in kisspeptin in GnRH-deficient hypogonadal mice. [PDF]
PLoS ONE, 2010 Kisspeptin is a potent activator of GnRH-induced gonadotropin secretion and is a proposed central regulator of pubertal onset. In mice, there is a neuroanatomical separation of two discrete kisspeptin neuronal populations, which are sexually dimorphic ...
John C Gill +5 more
doaj +5 more sources
Low Degree of Overlap Between Kisspeptin, Neurokinin B, and Dynorphin Immunoreactivities in the Infundibular Nucleus of Young Male Human Subjects Challenges the KNDy Neuron Concept. [PDF]
, 2012 Previous immunohistochemical and in situ hybridization studies of sheep, goats, and rodents indicated that kisspeptin (KP), neurokinin B (NKB), and dynorphin A (DYN) are extensively colocalized in the hypothalamic arcuate nucleus, thus providing a basis ...
Borsay, Beáta Ágnes +7 more
core +3 more sources