Results 11 to 20 of about 21,456 (303)

Heat Stress during Summer Attenuates Expression of the Hypothalamic Kisspeptin, an Upstream Regulator of the Hypothalamic–Pituitary–Gonadal Axis, in Domestic Sows

Animals, 2022
The release of reproductive hormones in the hypothalamic–pituitary–gonadal (HPG) axis is regulated by its upstream regulator, kisspeptin, and influenced by external stresses, including heat stress.
Hwan-Deuk Kim, Young-Jong Kim, Min Jang, Seul-Gi Bae, Sung-Ho Yun, Mi-Ree Lee, Yong-Ryul Seo, Jae-Keun Cho, Seung-Joon Kim, Won-Jae Lee   +9 more
doaj   +2 more sources

Conditional kisspeptin neuron-specific Kiss1 knockout with newly generated Kiss1-floxed and Kiss1-Cre mice replicates a hypogonadal phenotype of global Kiss1 knockout mice [PDF]

The Journal of Reproduction and Development, 2020
The present study aimed to evaluate whether novel conditional kisspeptin neuron-specific Kiss1 knockout (KO) mice utilizing the Cre-loxP system could recapitulate the infertility of global Kiss1 KO models, thereby providing further evidence for the ...
Kana IKEGAMI, Teppei GOTO, Sho NAKAMURA, Youki WATANABE, Arisa SUGIMOTO, Sutisa MAJARUNE, Kei HORIHATA, Mayuko NAGAE, Junko TOMIKAWA, Takuya IMAMURA, Makoto SANBO, Masumi HIRABAYASHI, Naoko INOUE, Kei-ichiro MAEDA, Hiroko TSUKAMURA, Yoshihisa UENOYAMA   +15 more
doaj   +3 more sources

Functional examination of novel kisspeptin phosphinic peptides. [PDF]

PLoS ONE, 2018
Kisspeptins acting on their cognate G protein-coupled receptor, kisspeptin receptor, play important roles in the suppression of cancer cell metastasis and regulation of the reproductive system, and therefore are important for therapeutic intervention ...
Xiaoyang Zhang, Magdalini Matziari, Yixin Xie, David Fernig, Rong Rong, Jia Meng, Zhi-Liang Lu   +6 more
doaj   +6 more sources

Female sexual behavior in mice is controlled by kisspeptin neurons

Nature Communications, 2018
Sexual behavior is essential for the survival of many species. In female rodents, mate preference and copulatory behavior depend on pheromones and are synchronized with ovulation to ensure reproductive success.
Olivier Brock, Christian Mayer, Richard Piet   +2 more
exaly   +2 more sources

Prolactin-mediates a lactation-induced suppression of arcuate kisspeptin neuronal activity necessary for lactational infertility in mice

eLife
The specific role that prolactin plays in lactational infertility, as distinct from other suckling or metabolic cues, remains unresolved. Here, deletion of the prolactin receptor (Prlr) from forebrain neurons or arcuate kisspeptin neurons resulted in ...
Eleni CR Hackwell, Sharon R Ladyman, Jenny Clarkson, H James McQuillan, Ulrich Boehm, Allan E Herbison, Rosemary SE Brown, David R Grattan   +7 more
doaj   +2 more sources

Kisspeptin Administration and mRNA Expression in Adult Syrian Hamsters. [PDF]

Cells
Kisspeptin (Kiss1) and kisspeptin 1 receptor (Kiss1R) are vital in regulating various functions across many species, primarily those relating to reproduction.
Hall MAL, Reeder PL, Borland JM, Meisel RL.   +3 more
europepmc   +2 more sources

Reproductive hormone-dependent and -independent contributions to developmental changes in kisspeptin in GnRH-deficient hypogonadal mice. [PDF]

PLoS ONE, 2010
Kisspeptin is a potent activator of GnRH-induced gonadotropin secretion and is a proposed central regulator of pubertal onset. In mice, there is a neuroanatomical separation of two discrete kisspeptin neuronal populations, which are sexually dimorphic ...
John C Gill, Oulu Wang, Shelley Kakar, Enzo Martinelli, Rona S Carroll, Ursula B Kaiser   +5 more
doaj   +5 more sources

Metabolic regulation of kisspeptin — the link between energy balance and reproduction

Nature Reviews Endocrinology, 2020
Victor M Navarro
exaly   +2 more sources

Hyperalgesic activity of kisspeptin in mice. [PDF]

Molecular Pain, 2011
BACKGROUND: Kisspeptin is a neuropeptide known for its role in the hypothalamic regulation of the reproductive axis. Following the recent description of kisspeptin and its 7-TM receptor, GPR54, in the dorsal root ganglia and dorsal horns of the spinal ...
Biagioni, Francesca, Biasiotta, Antonella, Chiechio, Santina, Colledge, William H, Copani, Agata, Cruccu, Giorgio, Nicoletti, Ferdinando, Sortino, Maria Angela, Spampinato, Simona, Trabucco, Angela   +9 more
core   +7 more sources

KNDy neurons as an indirect target of insulin-like growth factor-1. [PDF]

J Neuroendocrinol
Abstract Neurons in the arcuate nucleus of the hypothalamus (ARH) that coexpress kisspeptin, neurokinin B, and dynorphin (KNDy neurons) are considered the gonadotropin‐releasing hormone (GnRH) pulse generator necessary for fertility. KNDy neurons are also metabolic sensors controlling the hypothalamic–pituitary‐gonadal (HPG) axis.
Silva JDN, de Sousa LMM, de Sousa ME, Vieira HR, Alves GA, Neifert NT, Moore AM, Donato J, Frazao R.   +8 more
europepmc   +2 more sources