Results 181 to 190 of about 2,975 (220)
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2013
Kisspeptin is now known to be an important regulator of the hypothalamic--pituitary-gonadal axis and is the target of a range of regulators, such as steroid hormone feedback, nutritional and metabolic regulation. Kisspeptin binds to its cognate receptor, KISS1R (also called GPR54), on GnRH neurons and stimulates their activity, which in turn provides ...
Antonia Kathryn, Roseweir +1 more
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Kisspeptin is now known to be an important regulator of the hypothalamic--pituitary-gonadal axis and is the target of a range of regulators, such as steroid hormone feedback, nutritional and metabolic regulation. Kisspeptin binds to its cognate receptor, KISS1R (also called GPR54), on GnRH neurons and stimulates their activity, which in turn provides ...
Antonia Kathryn, Roseweir +1 more
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Immunocytochemical localization of kisspeptin and kisspeptin receptor in the primate testis
Journal of Medical Primatology, 2016AbstractBackgroundHypothalamic kisspeptin–kisspeptin receptor signalling in primates ensures the successful progression into puberty during development and maintenance of reproductive capacity during adulthood. Human testis has been shown to express high‐to‐moderate levels of kisspeptin and kisspeptin receptor gene expression.
Shahzad, Irfan +4 more
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Seminars in Reproductive Medicine, 2007
Although the functions of kisspeptin originally were believed to be restricted to metastasis suppression, a novel role for this protein was discovered in 2003. Loss-of-function mutations in its receptor, GPR54, were found to cause absence of puberty and hypogonadotropic hypogonadism in humans.
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Although the functions of kisspeptin originally were believed to be restricted to metastasis suppression, a novel role for this protein was discovered in 2003. Loss-of-function mutations in its receptor, GPR54, were found to cause absence of puberty and hypogonadotropic hypogonadism in humans.
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Kisspeptin and Glucose Homeostasis
Seminars in Reproductive Medicine, 2019AbstractKisspeptin has well-established critical roles in the control of reproduction and fertility. Recently, evidence has emerged that suggests kisspeptin may have additional roles in the regulation of glucose homeostasis. Conflicting reports on the effects of kisspeptin on insulin secretion in animal models have been published, which cannot be fully
Izzi-Engbeaya, Chioma +2 more
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Kisspeptin and Seasonality of Reproduction
2013Wild and domesticated species display seasonality in reproductive function, controlled predominantly by photoperiod. Seasonal alterations in breeding status are caused by changes in the secretion of gonadotropin-releasing hormone (GnRH) that are mediated by upstream neuronal afferents that regulate the GnRH cells.
Clarke, Iain J, Caraty, Alain
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Kisspeptin as a Behavioral Hormone
Seminars in Reproductive Medicine, 2019AbstractSuccessful reproduction is dependent not only on hormonal endocrine responses but also on suitable partner selection, copulatory acts, as well as associated emotional, behavioral, and cognitive processes many of which are supported by the limbic system.
Mills, EGA, O'Byrne, KT, Comninos, AN
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Kisspeptin and Gynecological Cancer
Proceedings of the Fourth International Conference on Biological Information and Biomedical Engineering, 2020Background: Kisspeptin was identified in 1996 and it was known as a suppressor of metastatic malignant tumors. Kisspeptin and its receptor KISS1R have been identified as potential prognostic or therapeutic markers in cancers. Recent study suggested that kisspeptin plays an important role in gynecological cancer, including breast cancer, ovarian cancer,
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2008
The G-protein coupled receptor GPR54 has an essential role in the initiation and maintenance of mammalian fertility. Humans and mice with mutations in GPR54 have hypogonadotropic hypogonadism characterized by absence of sexual maturation and low levels of gonadotropic hormones (LH and FSH).
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The G-protein coupled receptor GPR54 has an essential role in the initiation and maintenance of mammalian fertility. Humans and mice with mutations in GPR54 have hypogonadotropic hypogonadism characterized by absence of sexual maturation and low levels of gonadotropic hormones (LH and FSH).
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Metabolic Regulation of Kisspeptin
2013Body energy balance and metabolic signals are important modulators of puberty and reproductive function, so that perturbations of metabolism and energy reserves (ranging from persistent energy insufficiency to morbid obesity) are frequently linked to reproductive disorders.
Juan Manuel, Castellano +1 more
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Expression of kisspeptins and kisspeptin receptor in the kidney of chronic renal failure rats
Peptides, 2010Kisspeptins are biologically active cleavage peptides of the KiSS-1 gene products with important roles in the suppression of tumor metastasis and in the reproduction. The aim of the present study is to clarify changes of the expression of kisspeptins and kisspeptin receptor in the kidney with and without chronic renal impairment.
Itaru, Shoji +13 more
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