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Kisspeptin and Gynecological Cancer
Proceedings of the Fourth International Conference on Biological Information and Biomedical Engineering, 2020Background: Kisspeptin was identified in 1996 and it was known as a suppressor of metastatic malignant tumors. Kisspeptin and its receptor KISS1R have been identified as potential prognostic or therapeutic markers in cancers. Recent study suggested that kisspeptin plays an important role in gynecological cancer, including breast cancer, ovarian cancer,
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2008
The G-protein coupled receptor GPR54 has an essential role in the initiation and maintenance of mammalian fertility. Humans and mice with mutations in GPR54 have hypogonadotropic hypogonadism characterized by absence of sexual maturation and low levels of gonadotropic hormones (LH and FSH).
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The G-protein coupled receptor GPR54 has an essential role in the initiation and maintenance of mammalian fertility. Humans and mice with mutations in GPR54 have hypogonadotropic hypogonadism characterized by absence of sexual maturation and low levels of gonadotropic hormones (LH and FSH).
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Metabolic Regulation of Kisspeptin
2013Body energy balance and metabolic signals are important modulators of puberty and reproductive function, so that perturbations of metabolism and energy reserves (ranging from persistent energy insufficiency to morbid obesity) are frequently linked to reproductive disorders.
Juan Manuel, Castellano +1 more
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Electrophysiology of Kisspeptin Neurons
2013Kisspeptin is an important regulator of reproduction. Electrophysiological studies show that kisspeptin neurons of the arcuate nucleus that co-localize neurokinin B and dynorphin (aka KNDy neurons) fire action potentials in a tonic, irregular, or burst firing manner. Gonadectomy dramatically alters the membrane properties of KNDY neurons from male mice
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