Results 121 to 130 of about 18,442 (279)

Transcription factor KLF2 regulates homeostatic NK cell proliferation and survival [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance Adoptive transfer of allogeneic natural killer (NK) cells into leukemia patients can lead to remission; however, therapies are hindered by inefficient expansion and limited persistence of these lymphocytes. We now report that Kruppel-like factor 2 (KLF2) regulates both NK cell proliferation and survival.
Whitney, Rabacal, Sudheer K, Pabbisetty, Kristen L, Hoek, Delphine, Cendron, Yin, Guo, Damian, Maseda, Eric, Sebzda   +6 more
openaire   +2 more sources

Heart rate reduction with ivabradine promotes shear stress-dependent anti-inflammatory mechanisms in arteries [PDF]

, 2016
Blood flow generates wall shear stress (WSS) which alters endothelial cell (EC) function. Low WSS promotes vascular inflammation and atherosclerosis whereas high uniform WSS is protective. Ivabradine decreases heart rate leading to altered haemodynamics.
Ali, M., Arnold, N., Bowden, N.P., Duckles, H., Evans, P.C., Feng, S., Gijsen, F.J., Gsell, W., Halliday, I., Hose, R., Lawrie, A., Lopez-Tremoleda, J.L., Lungu, A., Luong, L., Mahmoud, M., Ridger, V., Schenkel, T., Spencer, T., van der Heiden, K., Villa-Uriol, M., Wentzel, J., Wylezinska-Arridge, M., Xing, R.   +22 more
core   +2 more sources

Transcription factor KLF2 is associated with the dysfunctional status of NK cells and the prognosis of pediatric B-ALL patients

Frontiers in Oncology
Background Natural killer cells, an important component of the innate immune system, can directly recognize and lyse virally infected or transformed cells.
Fang Wu, Huimin Xu, Benshan Zhang
semanticscholar   +1 more source

The Role of Immune Infiltration and Oxidative Stress in the Progression of Cerebral Cavernous Malformation

Brain and Behavior, Volume 16, Issue 2, February 2026.
Mechanism of rupture hemorrhage in cerebral cavernous malformations. Environmental and immune factors promote the progression of lesions and induce the risk of abnormal formation or rupture of cerebrovascular vessels. Abstract Purpose of Review To review how the immune microenvironment and oxidative stress modulate the initiation, maturation, and ...
Xuesai Zhu, Yizhi Yao, Tengbo Yu, Xiao Xiao   +3 more
wiley   +1 more source

Integrative cross‐tissue and spatially resolved single‐cell profiling uncovers tumour‐educated inflammatory remodelling of tissue‐resident macrophage ecosystem with immunotherapeutic prognostic significance in pan‐cancer

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Pan‐cancer analysis reveals an inflammatory phenotype remodeling of tissue‐resident macrophages (iTRM) in the tumor microenvironment, which is associated with immunosuppression. Tissue‐resident macrophages and monocyte‐derived macrophages exhibit convergent differentiation toward a similar inflammatory phenotype. iTRM‐enriched ecosystems are associated
Weikai Wang, Zibin Chen, Yuhan Huang, Zhihao Hu, Peixin Zhu, Zhuoli Huang, Jingzhi Lv, Ziru Liao, Yuhui Zheng, Chen Wei, Baibing Guan, Yin Zeng, Xinyue Zhu, Yafei Yang, Guibo Li, Xin Jin, Xi Chen, Xiao Yang, Zikun Ma, Jianhua Yin   +19 more
wiley   +1 more source

Statins Exert Endothelial Atheroprotective Effects via the KLF2 Transcription Factor [PDF]

Journal of Biological Chemistry, 2005
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, statins, have been shown to positively impact vascular function independent of their plasma lipid-lowering action. Several of these beneficial effects involve modulation of gene expression.
Kush M, Parmar, Vinod, Nambudiri, Guohao, Dai, H Benjamin, Larman, Michael A, Gimbrone, Guillermo, García-Cardeña   +5 more
openaire   +2 more sources

ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma. [PDF]

, 2016
ZNF750 controls epithelial homeostasis by regulating epidermal-differentiation genes, a role underscored by its pathogenic mutations in esophageal squamous cell cancers (SCCs). However, the precise role of ZNF750 in SCC cell biology remains unclear.
Chen, Y, Ding, L-W, Handral, H, Hazawa, M, Jiang, Y-Y, Koeffler, HP, Lin, D-C, Mayakonda, A, Meng, X, Movahednia, MM, Samuel, S, Sharma, A, Tong, C, Wong, RW, Xu, L, Yang, H   +15 more
core   +2 more sources

Integrative single‐cell analysis uncovers distinct tumour microenvironment ecotypes and immune evasion across skin cancers

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Graphical highlights Tumour subpopulations with high malignancy show reduced interferon signalling and reduced MHC‐I expression. Tumour‐associated macrophages (TAMs) differentiate into two opposing states: SPP1+ TAMs and CXCL9+ TAMs. Among immune ecotypes, T‐cell‐enriched ecotypes are linked with high MHC‐I expression in tumour cells while desert ...
Lingjuan Huang, Huihui Hou, Xiyuan Zhang, Liang Dong, Wensheng Shi, Mason Liu, Jie Sun, Anil Prakash, Haoqiu Song, Shiyao Pei, Xin Li, Xiang Chen, Shenglin Mei, Mingzhu Yin   +13 more
wiley   +1 more source

Regulation of the cardiomyocyte transcriptome vs translatome by endothelin-1 and insulin: translational regulation of 5' terminal oligopyrimidine tract (TOP) mRNAs by insulin [PDF]

, 2010
Background: Changes in cellular phenotype result from underlying changes in mRNA transcription and translation. Endothelin-1 stimulates cardiomyocyte hypertrophy with associated changes in mRNA/protein expression and an increase in the rate of protein ...
Clerk, Angela, Cullingford, Timothy E., Markou, Thomais, Marshall, Andrew Keith, Sugden, Peter H., Tham, El Li   +5 more
core   +3 more sources

TRβ activation confers AT2-to-AT1 cell differentiation and anti-fibrosis during lung repair via KLF2 and CEBPA

Nature Communications
Aberrant repair underlies the pathogenesis of pulmonary fibrosis while effective strategies to convert fibrosis to normal regeneration are scarce. Here, we found that thyroid hormone is decreased in multiple models of lung injury but is essential for ...
X. Pan, Lan Wang, Juntang Yang, Yingge Li, Min Xu, Chenxi Liang, Lulu Liu, Zhongzheng Li, Cong Xia, Jiaojiao Pang, Mengyuan Wang, Meng Li, Saiya Guo, Peishuo Yan, Chen Ding, Ivan O Rosas, Guoying Yu   +16 more
semanticscholar   +1 more source