Results 21 to 30 of about 55,031 (288)

ACTL6A depletion induces KLF4-mediated anti-tumorigenic effects in colorectal cancer [PDF]

Cell Death Dis
Yang H, Kim E, Kim Y, Cho Y, Choi Y, Song S, Kim T.   +6 more
europepmc   +3 more sources

Krüppel-like factor 4, a tumor suppressor in hepatocellular carcinoma cells reverts epithelial mesenchymal transition by suppressing slug expression. [PDF]

PLoS ONE, 2012
Krüppel-like factor 4 (KLF4) is a zinc-finger transcription factor that plays an important role in differentiation and pathogenesis. KLF4 has been suggested to act as an oncogene or tumor suppressor in different tumor types.
Ze-Shiang Lin, Hsiao-Chien Chu, Yi-Chen Yen, Brian C Lewis, Ya-Wen Chen   +4 more
doaj   +1 more source

KLF4 Inhibits the Differentiation of Goat Intramuscular Preadipocytes Through Targeting C/EBPβ Directly

Frontiers in Genetics, 2021
Intramuscular fat (IMF) deposition is a complicated process, and most of the underlying regulators of this biological process are unknown. Here, we cloned the intact CDS of KLF4 gene, investigated the role of KLF4 by gaining or losing function in vitro ...
Qing Xu, Qing Xu, Qing Xu, Yanyan Li, Yanyan Li, Sen Lin, Sen Lin, Yong Wang, Yong Wang, Yong Wang, Jiangjiang Zhu, Jiangjiang Zhu, Yaqiu Lin, Yaqiu Lin, Yaqiu Lin   +14 more
doaj   +1 more source

KLF4 regulation in intestinal epithelial cell maturation [PDF]

Experimental Cell Research, 2008
The Krüppel-like factor 4 (KLF4) transcription factor suppresses tumorigenesis in gastrointestinal epithelium. Thus, its expression is decreased in gastric and colon cancers. Moreover, KLF4 regulates both differentiation and growth that is likely fundamental to its tumor suppressor activity.
Flandez, M., Guilmeau, Sandra, Blache, P., Augenlicht, L.H.   +3 more
openaire   +2 more sources

MiR-135b-5p promotes viability, proliferation, migration and invasion of gastric cancer cells by targeting Krüppel-like factor 4 (KLF4)

Archives of Medical Science, 2019
Introduction The expression of MiR-135b-5p was up-regulated while Krüppel-like factor 4 (KLF4) expression was extremely low in human gastric carcinoma (GC) tissues.
Zhi Chen, Yongjian Gao, Shuohui Gao, Defeng Song, Ye Feng   +4 more
doaj   +1 more source

Krüppel-like factors in cancer progression: three fingers on the steering wheel [PDF]

, 2013
Kruppel-like factors (KLFs) comprise a highly conserved family of zinc finger transcription factors, that are involved in a plethora of cellular processes, ranging from proliferation and apoptosis to differentiation, migration and pluripotency.
de Beeck, Ken Op, De Wever, Olivier, Lardon, Filip, LIMAME, RIDHA, Pauwels, Patrick   +4 more
core   +3 more sources

Gene Expression Profile Changes After Short-activating RNA-mediated Induction of Endogenous Pluripotency Factors in Human Mesenchymal Stem Cells [PDF]

, 2012
It is now recognized that small noncoding RNA sequences have the ability to mediate transcriptional activation of specific target genes in human cells.
Alluin, J, Habib, N, Kasahara, N, Mintz, P, Rossi, J, Sun, G, Sætrom, P, Voutila, J   +7 more
core   +4 more sources

Generation of induced pluripotent stem cell line, CSSi004-A (2962), from a patient diagnosed with Huntington's disease at the presymptomatic stage [PDF]

, 2018
Huntington's disease (HD) is an incurable, autosomal dominant, hereditary neurodegenerative disorder that typically manifests itself in midlife. This pathology is linked to the deregulation of multiple, as yet unknown, cellular processes starting before ...
Bernardini, Laura, Bidollari, Eris, Candido, Ornella, Consoli, Federica, De Luca, Alessandro, Ferrari, Daniela, Ilari, Andrea, Lamorte, Giuseppe, Rosati, Jessica, Rotundo, Giovannina, Santimone, Iolanda, Squitieri, Ferdinando, Vescovi, Angelo Luigi   +12 more
core   +6 more sources

KLF4 (Kruppel-like factor 4 (gut)) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on KLF4 (Kruppel-like factor 4 (gut)), with data on DNA, on the protein encoded, and where the gene is implicated.
Ghaleb, AM, Yang, VW
openaire   +2 more sources

MicroRNAs-Proteomic Networks Characterizing Human Medulloblastoma-SLCs [PDF]

, 2016
Medulloblastoma (MB) is the most common malignant brain tumor of pediatric age and is characterized by cells expressing stem, astroglial, and neuronal markers.
Alfano, Vincenzo, Besharat, ZEIN MERSINI, Carai, Andrea, Catanzaro, Giuseppina, Ferretti, Elisabetta, Garg, Neha, Locatelli, Franco, Mastronuzzi, Angela, Miele, Evelina, Pieroni, Luisa, Po, Agnese, Ronci, Maurizio, Screpanti, Isabella, Urbani, Andrea   +13 more
core   +4 more sources