Results 31 to 40 of about 55,031 (288)
Frontiers in Oncology, 2021 Paclitaxel (PTX) is a first-line chemotherapeutic drug for the treatment of breast cancer, but drug resistance seriously limits its clinical use. The aim of the present work was to explore the effect of 3,3’-diindolylmethane (DIM) on PTX sensitivity and ...
Fenfen Xiang +9 more
doaj +1 more source
GENERATION OF MOUSE INDUCED PLURIPOTENT STEM CELLS BY PROTEIN TRANSDUCTION. [PDF]
, 2013 Somatic cell reprogramming has generated enormous interest after the first report by Yamanaka and his coworkers in 2006 on the generation of induced pluripotent stem cells (iPSCs) from mouse fibroblasts. Here we report the generation of stable iPSCs from
Andras Dinnyes +6 more
core +1 more source
KLF4 regulates skeletal muscle development and regeneration by directly targeting P57 and Myomixer
Cell Death and Disease, 2023 Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes such as cell proliferation, apoptosis, and differentiation.
Shufang Cai +14 more
doaj +1 more source
Emerging role of KLF4 in human gastrointestinal cancer [PDF]
Carcinogenesis, 2005 Recent analyses revealed that Krüppel-like factors (KLFs) play important roles in both normal development and carcinogenesis. Of the 16 known KLFs, KLF4 has been shown to be involved in the regulation of proliferation, differentiation and tumorigenesis of gastrointestinal tract epithelium.
Daoyan, Wei +3 more
openaire +2 more sources
Role of FGFR2b expression and signaling in keratinocyte differentiation. Sequential involvement of PKCδ and PKCα [PDF]
, 2018 The tumor suppressor epithelial isoform of the fibroblast growth factor receptor 2 (FGFR2b) induces human keratinocyte early differentiation. Moreover, protein kinases C (PKCs) are known to regulate the differentiation program in several cellular ...
Belleudi, Francesca +4 more
core +2 more sources
DUB3/KLF4 combats tumor growth and chemoresistance in hepatocellular carcinoma
Cell Death Discovery, 2022 This study aimed to investigate the role of deubiquitinating enzyme 3 (DUB3) in the regulation of Krüppel-like factor 4 (KLF4) expression in hepatocellular carcinoma (HCC).
Xuebing Jia +16 more
doaj +1 more source
Frontiers in Genetics, 2023 Introduction: Although the molecular mechanisms of Krüpple-like factor 4 (KLF4) as a tumor suppressor in HCC tumorigenesis have been thoroughly examined, its clinical application in terms of precise prognostication and its influence on tumor immune ...
Desheng Chen +7 more
doaj +1 more source
EMBO Molecular Medicine, 2020 KLF4 plays a critical role in determining cell fate responding to various stresses or oncogenic signaling. Here, we demonstrated that KLF4 is tightly regulated by poly(ADP‐ribosyl)ation (PARylation).
Zhuan Zhou +9 more
doaj +1 more source
Unveiling combinatorial regulation through the combination of ChIP information and in silico cis-regulatory module detection [PDF]
, 2012 Computationally retrieving biologically relevant cis-regulatory modules (CRMs) is not straightforward. Because of the large number of candidates and the imperfection of the screening methods, many spurious CRMs are detected that are as high scoring as ...
Fierro, Ana Carolina +5 more
core +2 more sources
Krüppel-like factor 4 regulates intestinal epithelial cell morphology and polarity. [PDF]
PLoS ONE, 2012 Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor that plays a vital role in regulating cell lineage differentiation during development and maintaining epithelial homeostasis in the intestine.
Tianxin Yu +7 more
doaj +1 more source