Results 21 to 30 of about 1,946 (137)
Rapsyn's knobs and holes: eight tetratrico peptide repeats. [PDF]
Biochem J, 1996 Ponting CC, Phillips C.
europepmc +3 more sources
Bispecific antibodies with Fab-arms featuring exchanged antigen-binding constant domains
Biochemistry and Biophysics Reports, 2021 Monoclonal antibodies can acquire the property of engagement of a second antigen via fusion methods or modification of their CDR loops, but also by modification of their constant domains, such as in the mAb2 format where a set of mutated amino acid ...
Filippo Benedetti +5 more
doaj +1 more source
STAR Protocols, 2021 Summary: Follistatin-like 3 (FSTL3) is an endogenous antagonist against transforming growth factor-β family ligands. Monovalent FSTL3-Fc fusion protein (mono-FSTL3-Fc) generated with knobs-into-holes technology overcomes limitations of current anti ...
Takayuki Ozawa +2 more
doaj +1 more source
Crystal structure of an anti-Ang2 CrossFab demonstrates complete structural and functional integrity of the variable domain. [PDF]
PLoS ONE, 2013 Bispecific antibodies are considered as a promising class of future biotherapeutic molecules. They comprise binding specificities for two different antigens, which may provide additive or synergistic modes of action.
Sebastian Fenn +12 more
doaj +1 more source
An integrated approach for characterizing immunogenic responses toward a bispecific antibody
mAbs, 2021 Bispecific antibodies (bsAbs) recognize and bind two different targets or two epitopes of the same antigen, making them an attractive diagnostic and treatment modality.
Sivan Cohen +14 more
doaj +1 more source
‘Knobs-into-holes’ engineering of antibody CH3 domains for heavy chain heterodimerization [PDF]
"Protein Engineering, Design and Selection", 1996 'Knobs-into-holes' was originally proposed by Crick in 1952 as a model for the packing of amino acid side chains between adjacent alpha-helices. 'Knobs-into-holes' is demonstrated here as a novel and effective design strategy for engineering antibody heavy chain homodimers for heterodimerization.
J B, Ridgway, L G, Presta, P, Carter
openaire +2 more sources
iScience, 2021 Summary: Targeting the signaling pathway of growth differentiation factor 8 (GDF8), also known as myostatin, has been regarded as a promising strategy to increase muscle mass in the elderly and in patients.
Takayuki Ozawa +7 more
doaj +1 more source
iScience, 2022 Summary: Ebola virus (EBOV) and Marburg virus (MARV) are highly pathogenic viruses in humans, against which approved antivirals are lacking. During EBOV and MARV infection, coiled-coil mediated oligomerization is essential for the virion protein 35 (VP35)
Luca Zinzula +6 more
doaj +1 more source
Neuromodulation: Technology at the Neural Interface, EarlyView., 2021 Abstract Objectives Central poststroke pain (CPSP), a neuropathic pain condition, is difficult to treat. Repetitive transcranial magnetic stimulation (rTMS) targeted to the primary motor cortex (M1) can alleviate the condition, but not all patients respond. We aimed to assess a promising alternative rTMS target, the secondary somatosensory cortex (S2),
Juhani Ojala +10 more
wiley +1 more source
IMGT® Nomenclature of Engineered IGHG Variants Involved in Antibody Effector Properties and Formats
Antibodies, 2022 The constant region of the immunoglobulin (IG) or antibody heavy gamma chain is frequently engineered to modify the effector properties of the therapeutic monoclonal antibodies.
Marie-Paule Lefranc, Gérard Lefranc
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