Results 151 to 160 of about 763,072 (204)
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Seminars in Cancer Biology, 1996
The xeroderma pigmentosum group A correcting (XPA) gene encodes a DNA binding zinc-finger protein that recognizes DNA damage. As such the XPA protein participates in the initial step of the process of nucleotide excision repair. The multicomponent nucleotide excision repair pathway is one of the most thoroughly studied mechanisms that defends both ...
de Vries, A, van Steeg, H
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The xeroderma pigmentosum group A correcting (XPA) gene encodes a DNA binding zinc-finger protein that recognizes DNA damage. As such the XPA protein participates in the initial step of the process of nucleotide excision repair. The multicomponent nucleotide excision repair pathway is one of the most thoroughly studied mechanisms that defends both ...
de Vries, A, van Steeg, H
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Xenobiotic receptor knockout mice
Toxicology Letters, 1995Administration of certain foreign chemicals to animals elicits responses that are due to receptor-mediated activation of gene expression. Among the most well studied receptors are the Ah receptor (AHR) that binds 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds and the peroxisome proliferator-activated receptors, PPARs, that mediate gene ...
F J, Gonzalez +4 more
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Insulin Receptor Knockout Mice
Annual Review of Physiology, 2003▪ Abstract To examine the role of the insulin receptor in fuel homeostasis, we and others have carried out genetic ablation studies in mice. Mice lacking insulin receptors are born with normal features, but develop early postnatal diabetes and die of ketoacidosis.
Tadahiro, Kitamura +2 more
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Generating Conditional Knockout Mice
2010Gene targeting in ES cells is extensively used to generate designed mouse mutants and to study gene function in vivo. Knockout mice that harbor a null allele in their germline provide appropriate genetic models of inherited diseases and often exhibit embryonic or early postnatal lethality. To study gene function in adult mice and in selected cell types,
Roland H, Friedel +3 more
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Generating Rab6 Conditional Knockout Mice
2021RAB6 GTPase is the most abundant Golgi-associated RAB protein and regulates several transport steps at the level of this organelle. Homozygous Rab6a knockout (k/o) is embryonic lethal in mouse. To study RAB6 function in cell lineages and tissues, we thus generated various conditional Rab6a knockout (k/o) mice using the Cre/lox system.
Bardin, Sabine, Goud, Bruno
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Annexins – insights from knockout mice
Biological Chemistry, 2016Abstract Annexins are a highly conserved protein family that bind to phospholipids in a calcium (Ca2+) – dependent manner. Studies with purified annexins, as well as overexpression and knockdown approaches identified multiple functions predominantly linked to their dynamic and reversible membrane binding behavior.
Thomas, Grewal +3 more
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Rescue of Angiotensinogen-Knockout Mice
Biochemical and Biophysical Research Communications, 1998Angiotensinogen, the precursor of angiotensins I and II, is a critical component of the renin-angiotensin system that plays an important role in regulating blood pressure and electrolyte homeostasis. Genetically altered mice lacking angiotensinogen (Agt-KO) showed an expected phenotype, such as marked hypotension, but unexpected ones including abnormal
J, Ishida +9 more
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Knockout Mice in Xenobiotic Metabolism
Drug Metabolism Reviews, 2003Mice in which genes for drug metabolizing enzymes have been deleted or inactivated have great potential to further our understanding of the functions of these enzymes and their role in toxicology a...
Henderson, Colin J. +4 more
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Lessons from CRH knockout mice
Neuropeptides, 2002Corticotropin-releasing hormone (CRH), the major regulator of hypothalamic-pituitary-adrenal (HPA) axis, has a wide spectrum of actions within the central nervous system and the periphery. The development and use of Crh knockout mice (Crh-/-) has been an important tool for addressing the physiologic and pathologic roles of CRH.
M, Venihaki, J, Majzoub
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