Results 191 to 200 of about 2,060,910 (365)

The same but different: impact of animal facility sanitary status on a transgenic mouse model of Alzheimer's disease [PDF]

arXiv
The gut-brain axis has emerged as a key player in the regulation of brain function and cognitive health. Gut microbiota dysbiosis has been observed in preclinical models of Alzheimer's disease and patients. Manipulating the composition of the gut microbiota enhances or delays neuropathology and cognitive deficits in mouse models.
arxiv  

Effects of Castration and Chronic Steroid Treatments on Hypothalamic Gonadotropin-Releasing Hormone Content and Pituitary Gonadotropins in Male Wild-Type and Estrogen Receptor-α Knockout Mice [PDF]

, 1998
Jonathan Lindzey, William C. Wetsel, John F. Couse, Tammy E. Stoker, Ralph L. Cooper, Kenneth S. Korach   +5 more
openalex   +1 more source

Metabolic Consequences of Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry, Emily Sheng, Joshua F. Baker   +2 more
wiley   +1 more source

A novel functional role for apolipoprotein B in male infertility in heterozygous apolipoprotein B knockout mice.

, 1996
Li‐Shin Huang, Emanuel Voyiaziakis, H L Chen, Edward M. Rubin, Jon W. Gordon   +4 more
openalex   +1 more source

Endothelial Nitric Oxide Gene Knockout Mice [PDF]

, 1999
Xiao-Ping Yang, Yun-He Liu, Edward G. Shesely, Manohar Bulagannawar, Fang Liu, Oscar A. Carretero   +5 more
openalex   +1 more source

Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice

Neuron, 1996
S. Patterson, T. Abel, T. A. Deuel, K. Martin, J. C. Rose, E. Kandel   +5 more
semanticscholar   +1 more source

Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics

Advanced Biology, EarlyView.
This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim, Kanghoon Choi, Amy Lin, Jungkyu Kim   +3 more
wiley   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Increased Susceptibility of TNF-α Lymphotoxin-α Double Knockout Mice to Systemic Candidiasis Through Impaired Recruitment of Neutrophils and Phagocytosis ofCandida albicans [PDF]

, 1999
Mihai G. Netea, Lambertus J.H. van Tits, Jo H. A. J. Curfs, Franck Amiot, Jacques F. Meis, J.W.M. van der Meer, Bart Jan Kullberg   +6 more
openalex   +1 more source

Reeler/Disabled-like Disruption of Neuronal Migration in Knockout Mice Lacking the VLDL Receptor and ApoE Receptor 2

Cell, 1999
M. Trommsdorff, M. Gotthardt, T. Hiesberger, J. Shelton, W. Stockinger, J. Nimpf, R. Hammer, J. Richardson, J. Herz   +8 more
semanticscholar   +1 more source