Results 191 to 200 of about 34,694 (215)

Enterobacteriaceae producing the KPC-2 carbapenemase from hospital sewage

Diagnostic Microbiology and Infectious Disease, 2012
Fifteen isolates with reduced susceptibility to meropenem were obtained from hospital sewage. They contained bla(KPC-2) and belonged to multiple clones of Citrobacter freundii or Enterobacter cloacae. bla(KPC-2) was commonly carried by self-transmissible plasmids with different EcoRI-restricted patterns. Tn2 was identified upstream of bla(KPC-2), while
Xinzhuo, Zhang, Xiaoju, Lü, Zhiyong, Zong   +2 more
openaire   +2 more sources

Small IncQ1 Plasmid Encoding KPC-2 Expands to Invasive Nontyphoidal Salmonella

Antimicrobial Agents and Chemotherapy, 2021
The pandemic status of KPC-type carbapenemases has been linked especially to IncF, IncN, IncX, IncA/C, IncP, IncL/M, and IncR plasmids associated with the mobile element Tn4401, which have rapidly disseminated among international clones of Escherichia coli and Klebsiella complex (1, 2).….
Herrison Fontana, Brenda Cardoso, Fernanda Esposito, Aline Valerio de Lima, Jorge Luiz Mello Sampaio, Nilton Lincopan   +5 more
openaire   +2 more sources

Large hospital outbreak of KPC-2-producing Klebsiella pneumoniae: investigating mortality and the impact of screening for KPC-2 with polymerase chain reaction

Journal of Hospital Infection, 2015
Multi-drug-resistant Klebsiella pneumoniae carbapenemase (KPC)-2-producing K. pneumoniae are an increasing cause of healthcare-associated infections worldwide.To investigate the impact of clinical infection on mortality, and examine the effect of use of KPC-2-specific polymerase chain reaction (PCR) on the time to contact isolation during an outbreak ...
T, Ducomble, S, Faucheux, U, Helbig, U X, Kaisers, B, König, A, Knaust, C, Lübbert, I, Möller, A C, Rodloff, B, Schweickert, T, Eckmanns   +10 more
openaire   +2 more sources

Conformational Intermediate That Controls KPC-2 Catalysis and Beta-Lactam Drug Resistance [PDF]

ACS Catalysis, 2018
The KPC-2 carbapenemase enzyme is responsible for drug resistance in the majority of carbapenem-resistant gram-negative bacterial infections in the United States. A better understanding of what permits KPC-2 to hydrolyze carbapenem antibiotics and how this might be inhibited is thus of fundamental interest and great practical importance to development ...
George A Cortina, Peter Kasson
exaly   +4 more sources

Boronic acid inhibitors of the class A β-lactamase KPC-2

Bioorganic & Medicinal Chemistry, 2018
The rapid rise of antimicrobial resistance is one of the greatest challenges currently facing medical science. The most common cause of resistance to β-lactam antibiotics is the expression of β-lactamase enzymes, such as KPC-2. As such the development of novel inhibitors of KPC-2 and related enzymes is of the upmost importance. We report the design and
Jingyuan Zhou, Paul Stapleton, Shozeb Haider, Jess Healy   +3 more
openaire   +2 more sources

Isolation of Escherichia coli ST131 producing KPC-2 in Bulgaria

Infectious Diseases, 2017
Sir,A recent Chinese report in the present journal showed an escalating carbapenem resistance in Gram-negative bacteria.[1] Carbapenemase-encoding genes were detected in 50 of 71 carbapenem-resista...
Rumyana, Markovska, Temenuga, Stoeva, Lyudmila, Boyanova, Petya, Stankova, Daniela, Pencheva, Radka, Kaneva, Vanyo, Mitev, Ivan, Mitov   +7 more
openaire   +2 more sources

Treatment of KPC-2 Enterobacter cloacae empyema with cefepime and levofloxacin

Diagnostic Microbiology and Infectious Disease, 2014
Carbapenem-resistant Enterobacteriaceae infections are becoming more common, are associated with high mortality rates, and are difficult to treat due to multiple mechanisms of resistance. We describe the successful treatment of Klebsiella pneumoniae carbapenemase-expressing Enterobacter cloacae empyema in a lung transplant recipient with cefepime and ...
Anthony P, Cardile, Heather, Briggs, S Rodrigo, Burguete, Monica, Herrera, Brian L, Wickes, James H, Jorgensen   +5 more
openaire   +2 more sources

[The Transmission of KPC-2 Gene in Klebsiella Species].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2018
To explore the mechanisms of imipenem resistance inKlebsiella spp. and the transmission of Klebsiella pneumoniae Carbapenemase-2(KPC-2) gene in Klebsiella species.The imipenem resistant Klebsiella pneumoniae and Klebsiella oxytoca were isolated in the West China Hospital of Sichuan University in 2009/2010 and 2012/2013.
Li-Juan, Wu, Ting-Ting, Wang, Qing-Yan, He, Dan, Zhao, Si-Shi, Tang, Mei, Kang, Chao, He, Yi, Xie   +7 more
openaire   +1 more source

Cross-resistance to cefiderocol and ceftazidime–avibactam in KPC β-lactamase mutants and the inoculum effect

Clinical Microbiology and Infection, 2021
Claire Amaris Hobson, Olivier Tenaillon, André Birgy   +2 more
exaly  

KPC-Mediated Resistance to Ceftazidime-Avibactam and Collateral Effects in Klebsiella pneumoniae

Antimicrobial Agents and Chemotherapy, 2021
Jacqueline Findlay, Laurent Poirel, Patrice Nordmann   +2 more
exaly