Results 61 to 70 of about 161,113 (157)

Albumin‐Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity

Advanced Science, EarlyView.
This study demonstrates that an albumin‐bound STING agonist (Nano ZSA‐51D) reprograms HSPCs to produce antitumor neutrophils with enhanced MHC I–mediated CD8+ T cell activation, thereby sensitizing tumors to α‐PD1 therapy. These findings highlight a strategy to target early hematopoiesis for shaping neutrophil fate and potentiating cancer immunotherapy.
Jinsong Tao, Hong‐Yi Zhao, Chengyi Li, Hanning Wen, Fang Ke, Qiuxia Li, Miao He, Bo Wen, Zhongwei Liu, Kai Sun, Wei Gao, Duxin Sun   +11 more
wiley   +1 more source

Landslide Emergency Response Preparedness in Mining Areas: Early Warning System Implementation

The Indonesian Journal of Occupational Safety and Health
Introduction: Coal mining operations present serious risks due to landslip risks, necessitating the use of efficient early warning systems and emergency preparation. This paper examines the use of an early warning system called LASER (Land Sliding Alert)
Ardhila Chadarisman, Tedi Cahya Nusantara Herdianto   +1 more
doaj   +1 more source

Patient Perspectives on Psychiatric Polygenic Risk Scores in Reproductive Decision‐Making and Polygenic Embryo Screening

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Polygenic risk scores (PRS) estimate individuals' genetic risk for developing multifactorial conditions. Recent genome‐wide association studies have enabled development of psychiatric PRS, which hold potential to streamline diagnosis and treatment of psychiatric conditions.
Lauren A. Ginn, Amanda R. Merner, Page M. Trotter, Kaitlynn P. Craig, Abigail C. Martinez, Ana Lucía Battaglino, Dorit Barlevy, Daphne M. Ayton, Takahiro Soda, Eric A. Storch, Gabriel Lázaro‐Muñoz, Stacey Pereira   +11 more
wiley   +1 more source

Arp2/3 complex and β1 integrin drive an invasive front through extracellular matrix adaptation in pancreatic cancer

International Journal of Cancer, EarlyView.
What's New? Pancreatic ductal adenocarcinoma is characterized by a dense extracellular matrix, and how invasive tumor cells overcome such biomechanical constraints remains unclear. This study identifies the actin‐related protein 2/3 complex as a key regulator of pancreatic ductal adenocarcinoma invasiveness, driving fibroblast migration through β1 ...
Xiufen Yang, Yina Qiao, Yifeng Sun, Tamer Abdelaal, Kathleen Schuck, Hend Abdelrasoul, Carolina De La Torre, Malte Hermes, Yan Dong, Jingxiong Hu, Chao Fang, Xiaoyan Huang, Christoph Kahlert, Ingrid Herr, Christoph W. Michalski, Bo Kong   +15 more
wiley   +1 more source

Spatial Distribution of Abundance Patterns in the Starburst Galaxy NGC 3079 Revealed with Chandra and Suzaku

, 2012
We performed simultaneous spectral analysis of 26.6 ksec of Chandra and 102.3 ksec of Suzaku X-ray data of the starburst galaxy NGC 3079. The spectra are extracted from four regions: 0.5' (2.25 kpc) circle, an inner 0.5'-1' (2.25--4.5 kpc) ring, and an ...
Gandhi, Poshak, Konami, Saori, Matsushita, Kyoko, Tamagawa, Toru   +3 more
core   +1 more source

The metallicity gradient as a tracer of history and structure : the Magellanic Clouds and M33 galaxies [PDF]

, 2009
Original article can be found at: http://www.aanda.org/ Copyright The European Southern Observatory (ESO) DOI: 10.1051/0004-6361/200912138Context. The stellar metallicity and its gradient place constraints on the formation and evolution of galaxies. Aims.
Anders, Aparicio, Aparicio, Armandroff, Asplund, Barker, Battaglia, Battinelli, Battinelli, Battinelli, Bekki, Bernard, Besla, Borissova, Brooks, Brown, Butler, Carrera, Carrera, Carretta, Chandar, Chapman, Chiappini, Cioni, Cioni, Cioni, Cioni, Cioni, Cioni, Cioni, Cioni, Cioni, Cole, Cole, Da Costa, Da Costa, Davidge, Dufton, Edvardsson, Friedli, Gallart, Gallart, Glass, Gonidakis, Gordon, Grocholski, Grocholski, Harris, Harris, Hill, Hughes, Idiart, Jacoby, Kallivayalil, Kallivayalil, Karachentsev, Kennicutt, Kim, King, Lee, Lehner, Leisy, M.-R. L. Cioni, Ma, Magrini, Magrini, Majewski, Marigo, Martin, McConnachie, McLean, Minniti, Minniti, Momany, Nidever, Nöel, Parisi, Paturel, Piatti, Pompéia, Pont, Reid, Roskar, Rosolowsky, Sarajedini, Sarajedini, Schommer, Sellwood, Skillman, Soubiran, Subramaniam, Subramanian, Tiede, Tolstoy, van der Marel, van der Marel, van der Marel, Vlajic, Wakker, Williams, Zaritsky, Zaritsky   +101 more
core   +3 more sources

Multiplex visual nucleic acid detection via isothermal cascaded transcription of fluorescent RNA aptamers

VIEW, EarlyView.
(1) Existing multiplex nucleic acid detection struggles to combine high sensitivity, visual readout, and instrument‐free use, which is vital for rapid infection and antibiotic resistance diagnosis. (2) We developed MAGIC, integrating isothermal cascaded amplification and fluorescent RNA aptamer transcription, achieving 10 aM sensitivity, 100% accuracy ...
Yu Tang, Na Luo, Binbin Xie, Jie Luo, Yaling Yuan, Junjie Fan, Zhiyong Liu, Haiyan Gao, Ming Chen, Kai Chang   +9 more
wiley   +1 more source

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

Pediatric Blood &Cancer, Volume 73, Issue 4, April 2026.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell, Kavitha Srivatsa, Paola Angelini, Pei‐Chi Kao, Brady Payne, Arlene Naranjo, Sveva Castelli, Miho Kato, Miki Ohira, Ulriche Pöetschger, Yaël Mossé, Lucas Moreno, Meredith S. Irwin, Ramya Ramanujachar, Wendy B. London   +14 more
wiley   +1 more source

Phenotypic and enzymatic comparative analysis of the KPC variants, KPC-2 and its recently discovered variant KPC-15. [PDF]

PLoS ONE, 2014
Sixteen different variants (KPC-2 to KPC-17) in the KPC family have been reported, and most current studies are focusing on KPC-2 and KPC-3. The KPC-15 variant, which isolated from Klebsiella pneumoniae in a Chinese hospital, was a recently discovered ...
Dongguo Wang, Jiayu Chen, Linjun Yang, Yonghua Mou, Yijun Yang   +4 more
doaj   +1 more source

Outer structure of the Galactic warp and flare: explaining the Canis Major over-density

, 2005
(Abridged) We derive the structure of the Galactic stellar Warp and Flare using 2MASS RC and RGB stars, selected at mean heliocentric distances of 3, 7 and 17 kpc. Our results are: (i) a clear stellar warp signature is derived for the 3 selected rings;
Bedin, L. R., Carraro, G., De Angeli, F., Gilmore, G., Momany, Y., Piotto, G., Zaggia, S.   +6 more
core   +2 more sources