BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors [PDF]
Stem Cell Reports, 2016 Bone morphogenetic protein (BMP) signaling exerts paradoxical roles in pluripotent stem cells (PSCs); it sustains self-renewal of mouse embryonic stem cells (ESCs), while it induces differentiation in other PSCs, including human ESCs.
Masato Morikawa +10 more
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Krüppel-like Factors 4 and 5 in Colorectal Tumorigenesis. [PDF]
Cancers (Basel), 2023 Simple Summary Krüppel-like factors (KLFs) are zinc finger-containing transcription factors that play a crucial role in embryogenesis, development, homeostasis, and disease progression by regulating multiple signaling pathways.
Lee E, Cheung J, Bialkowska AB.
europepmc +2 more sources
Specificity Proteins (SP) and Krüppel-like Factors (KLF) in Liver Physiology and Pathology. [PDF]
Int J Mol Sci, 2023 The liver acts as a central hub that controls several essential physiological processes ranging from metabolism to detoxification of xenobiotics. At the cellular level, these pleiotropic functions are facilitated through transcriptional regulation in ...
Yerra VG, Drosatos K.
europepmc +2 more sources
Kruppel-like Factors in Skeletal Physiology and Pathologies. [PDF]
Int J Mol Sci, 2022 Kruppel-like factors (KLFs) belong to a large group of zinc finger-containing transcription factors with amino acid sequences resembling the Drosophila gap gene Krüppel.
Abe M, Saeki N, Ikeda Y, Ohba S.
europepmc +2 more sources
Krüppel‐Like Factors Orchestrate Endothelial Gene Expression Through Redundant and Non‐Redundant Enhancer Networks [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background Proper function of endothelial cells is critical for vascular integrity and organismal survival. Studies over the past 2 decades have identified 2 members of the KLF (Krüppel‐like factor) family of proteins, KLF2 and KLF4, as nodal regulators ...
David R. Sweet +9 more
doaj +2 more sources
Characterization of the prognostic values and response to immunotherapy/chemotherapy of Krüppel-like factors in prostate cancer. [PDF]
J Cell Mol Med, 2020 At present, the overall genetic and epigenetic effects of Krüppel‐like factors (KLFs) on prostate cancer (PCa) remain unclear. Therefore, we systematically investigated the molecular differences in KLFs of transcription expression, promoter methylation ...
Meng J +7 more
europepmc +2 more sources
Krüppel-like factors in mitochondrial quality control [PDF]
Frontiers in PhysiologyKrüppel-like factors (KLFs) are a group of transcription factors characterized by conserved zinc finger domains in the C-terminus, which are critically involved in basic cellular processes, including growth, differentiation, apoptosis, and angiogenesis ...
M. Y. Zhang +3 more
doaj +2 more sources
Exploring the Functionality of the Krüppel-like Factors in Kidney Development, Metabolism, and Diseases [PDF]
LifeThe kidneys contribute to the overall health of an organism by maintaining systemic homeostasis. This process involves various biological mechanisms, in which the Krüppel-like factors (KLFs), a family of transcription factors, are essential for ...
Itzel S. Salmon-Cabrales +10 more
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Krüppel-like Factors in the Gastrointestinal Tract [PDF]
CellsThe Krüppel-like factors (KLFs) are a family of transcriptional regulators that play crucial roles in regulating diverse cellular processes including development, proliferation, differentiation, metabolism, and carcinogenesis across various tissues. KLFs
Dharmendra Bhargava +2 more
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Evolutionary Protection of Krüppel-Like Factors 2 and 4 in the Development of the Mature Hemovascular System [PDF]
Frontiers in Cardiovascular Medicine, 2021 A properly functioning hemovascular system, consisting of circulating innate immune cells and endothelial cells (ECs), is essential in the distribution of nutrients to distant tissues while ensuring protection from invading pathogens.
David R. Sweet +5 more
doaj +2 more sources