The Krüppel-Like Factors and Control of Energy Homeostasis.
Endocr Rev, 2019 Nutrient handling by higher organisms is a complex process that is regulated at the transcriptional level. Studies over the past 15 years have highlighted the critical importance of a family of transcriptional regulators termed the Krüppel-like factors ...
Hsieh PN, Fan L, Sweet DR, Jain MK.
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Krüppel-like factors compete for promoters and enhancers to fine-tune transcription. [PDF]
Nucleic Acids Res, 2017 Krüppel-like factors (KLFs) are a family of 17 transcription factors characterized by a conserved DNA-binding domain of three zinc fingers and a variable N-terminal domain responsible for recruiting cofactors.
Ilsley MD +6 more
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Unveiling myometrial SP/Krüppel-like factors as drivers of parturition: insights from transcriptional and endocrine regulatory networks [PDF]
Endocrine ConnectionsParturition is a complex process that is subject to multifactorial regulation by signals originating from the fetus, placenta, and uterus. The uterine myometrium is a central player for achieving successful pregnancy to term, requiring its transformation
Frank A Simmen, Rosalia C M Simmen
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Transcriptional Regulation of the Bovine Fatty Acid Transport Protein 1 Gene by Krüppel-Like Factors 15 [PDF]
Animals, 2019 Oleic acid is a major monounsaturated fatty acid, which accounts for about 33% of the fatty acid content in beef and is considered to have the least negative effect on serum cholesterol levels. Fatty acid transport protein 1 (FATP1), an integral membrane
Zhidong Zhao +5 more
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Krüppel-like factor 6 regulates transforming growth factor-β gene expression during human respiratory syncytial virus infection [PDF]
Virology Journal, 2011 Background Human respiratory syncytial virus (RSV) infection is associated with airway remodeling and subsequent asthma development. Transforming growth factor-beta (TGF) plays a crucial role in asthma development.
Chang TeHung +3 more
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Krüppel-like factors and vascular wall homeostasis. [PDF]
J Mol Cell Biol, 2017 Fan Y +5 more
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Mammalian Krüppel-like factors in health and diseases. [PDF]
Physiol Rev, 2010 McConnell BB, Yang VW.
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Krüppel-like factors in mammalian stem cells and development.
Development, 2017 Bialkowska AB, Yang VW, Mallipattu SK.
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Kruppel-like factors in muscle health and disease. [PDF]
Trends Cardiovasc Med, 2015 Prosdocimo DA, Sabeh MK, Jain MK.
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The critical role of Krüppel-like factors in kidney disease.
Am J Physiol Renal Physiol, 2017 Mallipattu SK, Estrada CC, He JC.
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