Results 221 to 230 of about 3,604,308 (302)

The Epistemic Generativity of Using a Model of a Big Idea

Science Education, Volume 110, Issue 3, Page 803-825, May 2026.
ABSTRACT Science instruction should involve learners in generating and warranting ideas, what we call epistemic generation. In modeling instruction, epistemic generation should be achieved by coordinating a model structure with the experienced world in reciprocal directions denoted as developing models and using models. In the former, a model structure
Jonathan T. Shemwell, Daniel K. Capps
wiley   +1 more source

Multi‐Sensor Spatiotemporal Fusion for 30‐m Daily Gapless Snow Cover Mapping

Water Resources Research, Volume 62, Issue 5, May 2026.
Abstract High spatiotemporal resolution remote sensing data is crucial for monitoring heterogeneous mountainous snow cover. Although spatiotemporal fusion presents a promising approach for high‐resolution snow monitoring, cloud contamination and sparse observations remain a critical constraint on its large‐scale and long‐term implementation. To address
Jinhang Wu, Xueliang Zhang, Pengfeng Xiao, Yumeng Jia, Bo Tang, Yan Liu   +5 more
wiley   +1 more source

How Salmonella Works Under Osmotic and Desiccation Stresses

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT Salmonella remains one of the leading threats in foods with reduced water activity, where it can survive for long periods and cause outbreaks. Its persistence stems from a wide array of adaptive strategies shaped by the selective pressures imposed by low‐moisture foods.
Mayara Messias Oliveira, Dionisio P. Amorim‐Neto, Anderson S. Sant'Ana   +2 more
wiley   +1 more source

Comparison of the effect of the aerobic glycolysis inhibitor dichloroacetate and of the Krebs cycle inhibitor LW6 on cellular and humoral alloimmunity. [PDF]

Biomed Rep, 2017
Eleftheriadis T, Pissas G, Mavropoulos A, Liakopoulos V, Stefanidis I.   +4 more
europepmc   +1 more source

Ecosystem valuation: Concept, criteria and terminology

Methods in Ecology and Evolution, Volume 17, Issue 5, Page 1480-1484, May 2026.
Abstract Furlaud et al. (2026) discussed how to measure ‘ecosystem condition’. Here, we argue that the term ‘ecosystem valuation’ should be preferred. ‘Valuation’ signals clearly that a social or political value judgement is being made about which ecosystem states to rate most highly. Furlaud et al.
Mark Westoby, David Coleman, David J. Eldridge, Robert M. Kooyman, Martyna Kotowska, Max Mallen‐Cooper, Julian Schrader, Ian W. Watson   +7 more
wiley   +1 more source

UNC45B Reduction With Aging: A Myofiber‐Intrinsic Promoting Factor for Sarcopenia

Aging Cell, Volume 25, Issue 5, May 2026.
Aging reduces Unc45b expression in fast‐twitch muscle, concomitant with reduction in muscle contractile capacity and muscle mass in mice. Unc45b deficiency initially reduces depolarization‐induced force, followed by a decline in fast‐twitch muscle mass in adult mice.
Taiga Mishima, Taiga Nagamune, Saori Tada, Daiki Watanabe, Nao Tokuda, Takashi Yamada, Akiko Hashimoto‐Hachiya, Sayaka Higo‐Yamamoto, Kohei Kido, Noriyuki Nagaoka, Aoi Ikedo, Yuuki Imai, Ryo Fujita, Seiya Mizuno, Satoru Takahashi, Katsutaka Oishi, Satoru Ato, Riki Ogasawara   +17 more
wiley   +1 more source

The Mitochondrial NAD Transporter SLC25A51 in Adipocytes Regulates Adipose Tissue Mitochondrial Function and Systemic Metabolism During Aging

Aging Cell, Volume 25, Issue 5, May 2026.
We revealed the pathophysiological significance and therapeutic potential of adipocyte mitochondrial NAD transporter, namely solute carrier family 25 member 51 (SLC25A51), in age‐associated metabolic diseases, particularly adipose tissue mitochondrial function, obesity, and insulin resistance, by analyzing adipocyte‐specific Slc25a51 knockout (ASKO ...
Daiki Kojima, Keisuke Yaku, Shotaro Kosugi, Ryunosuke Mitsuno, Kenji Kaneko, Yoshinaga Kawano, Akihito Hishikawa, Seiya Mizuno, Manami Katoh, Akiko Satoh, Shinya Toyokuni, Tatsuhiko Azegami, Kenichiro Kinouchi, Shintaro Yamaguchi, Hiroshi Itoh, Takeshi Kanda, Toshimasa Yamauchi, Takashi Nakagawa, Kaori Hayashi, Jun Yoshino   +19 more
wiley   +1 more source

Maternal exercise improves vascular function in hypertensive offspring via A‐kinase anchoring protein 150 gene (Akap5) epigenetic modifications

British Journal of Pharmacology, Volume 183, Issue 10, Page 2592-2612, May 2026.
Background and Purpose Regular physical activity is an effective non‐pharmacological approach to hypertension management and maternal exercise improves offspring cardiovascular health, although mechanisms remain unclear. A‐kinase anchoring protein 150 (AKAP150) targets protein kinase Cα to L‐type Ca2+ channels (CaV1.2), enhancing vascular tone in ...
Fang Qiu, Yanyan Zhang, Meiling Shan, Jiaqi Cao, Zihan Fan, Zhaoxia Xu, Xiaozhen Ding, Xiaodong Liu, Lijun Shi   +8 more
wiley   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Characterising Ecosystem Composition, Structure and Function of Alternative Stable States in Temperate Forests of South‐Eastern Australia

Global Change Biology, Volume 32, Issue 5, May 2026.
Alternative stable states established following repeated short‐interval fires in resprouting Eucalyptus temperate forests were associated with declines across multiple ecosystem functions. For example, carbon storage potential was significantly reduced (b: p < 0.001), with alternative states storing substantially less carbon than reference forests ...
Aaron E. Heap, Tom A. Fairman, Trent D. Penman, Lauren T. Bennett   +3 more
wiley   +1 more source