Results 1 to 10 of about 3,999 (188)

Importance of TREC and KREC as molecular markers for immunological evaluation of down syndrome children [PDF]

Scientific Reports, 2023
Recurrent and severe infections occurred in children with Down Syndrome (DS) due to immunological parameter defects have been reported. The aim of the study is to evaluate the importance of using T-cell receptor excision circle (TREC) and kappa-deleting ...
Eman Eissa, Hanan H. Afifi, Assem M. Abo-Shanab, Manal M. Thomas, Mohamed B. Taher, Rania Kandil, Naglaa M. Kholoussi   +6 more
doaj   +5 more sources

Decreased TREC and KREC levels in newborns with trisomy 21 [PDF]

Frontiers in Pediatrics
Newborn screening (NBS) for severe combined immunodeficiency (SCID) has been widely implemented to enable early detection and intervention. Trisomy 21, commonly known as Down syndrome (DS), poses unique challenges in NBS due to its frequent association ...
Andrey Marakhonov, Anna Mukhina, Elena Vlasova, Irina Efimova, Natalya Balinova, Yulia Rodina, Dmitry Pershin, Zhanna Markova, Marina Minzhenkova, Nadezhda Shilova, Dzhaina Mudaeva, Djamila Saydaeva, Taisiya Irbaieva, Svetlana Matulevich, Elena Belyashova, Grigoriy Yakubovskiy, Inna Tebieva, Yulia Gabisova, Murat Ikaev, Nataliya Irinina, Liya Nurgalieva, Elena Saifullina, Tatiana Belyaeva, Olga Romanova, Sergey Voronin, Rena Zinchenko, Anna Shcherbina, Sergey Kutsev   +27 more
doaj   +4 more sources

Assessment of trec and krec levels in COVID-19 patients with varying disease severity

Инфекция и иммунитет, 2023
According to the WHO data, the number of infected people exceeded 765.2 million people during the COVID-19 pandemic. The severity of patient’s condition is determined by immune system hyperactivation.
M. A. Saitgalina, Yulia V. Ostankova, Natalia A. Arsentieva, Zoya R. Korobova, Natalia E. Liubimova, Victor A. Kashchenko, Alexandr N. Kulikov, Dmitry E. Pevtsov, Oksana V. Stanevich, Ekaterina I. Chernykh, Areg A. Totolian   +10 more
doaj   +3 more sources

Implementation of TREC/KREC detection protocol for newborn SCID screening in Bulgaria: a pilot study [PDF]

Central European Journal of Immunology, 2023
Neonatal screening for inborn errors of immunity (IEI), based on quantification of T-cell-receptor- excision circles (TRECs) and kappa-deleting recombination-excision circles (KRECs) from dried blood spots (DBS), allows early diagnosis and improved ...
Marina Marinova, Atanaska Georgyeva, Viktoriya Yordanova, Nedelcho Ivanov, Valentina Atanasova, Elissaveta Naumova, Snezhina Mihailova Kandilarova   +6 more
doaj   +3 more sources

TREC/KREC Levels and T and B Lymphocyte Subpopulations in COVID-19 Patients at Different Stages of the Disease [PDF]

Viruses, 2022
Background: T and B cell-mediated immunity can be assessed using T cell receptor excision circle (TREC) and Kappa-deleting recombination excision circle (KREC) analysis, respectively, and successful implementation of this method requires evaluation of ...
Andrei A. Savchenko, Elena Tikhonova, Igor Kudryavtsev, Dmitry Kudlay, Ilya Korsunsky, Vasily Beleniuk, Alexandr Borisov   +6 more
doaj   +3 more sources

Case report: IKZF1-related early-onset CID is expected to be missed in TREC-based SCID screening but can be identified by determination of KREC levels. [PDF]

Front Immunol, 2023
This report illustrates a case that would have been missed in the most common screening algorithms used worldwide in newborn screening (NBS) for severe combined immunodeficiency (SCID).
Äng C, Zetterström RH, Ramme K, Axelsen E, Marits P, Sundin M.   +5 more
europepmc   +4 more sources

Comparative analysis of TREC and KREC concentration levels in children at medical and biological risk (CHD – frequently ill children, children who have been operated for congenital heart defect with combined thymectomy, children – without it) and those conditionally healthy

Медицинская иммунология
The purpose of the study was to compare and analyze the levels of KREC (kappa-deleting recombination excision circle) and TREC (T cell receptor excision circle) levels, which indirectly reflect impaired maturation of T and/or B lymphocytes, in children ...
Yu. I. Rovda, A. V. Vedernikova, A. V. Shabaldin, M. L. Filipenko, A. A. Sinitskaya, I. K. Khalivopulo, E. O. Grishacheva, G. A. Otstavnov, Ya. V. Shkitin, N. N. Minyailova, T. S. Khobotkova, V. V. Dadonov   +11 more
doaj   +3 more sources

Comparative analysis of two TREC/KREC quantification methods for newborn screening of primary immunodeficiency with T- and B-lymphopenia used in Ukraine

Біологічні студії
Background. Primary immunodeficiency (PID) compromise the immune system, leaving newborns highly vulnerable to infections. Severe combined immunodeficiency (SCID) is the most severe form, characterized by the absence or dysfunction of T and B cells ...
Volodymyr Kravets, Ivanna Shymanska, Oksana Boyarchuk, Nataliya Matiytsiv, Oksana Arkhipova, Halyna Makukh   +5 more
doaj   +3 more sources

Exploring TREC and KREC Levels in Nursing Home Residents and Staff and Their Association with SARS-CoV-2 Antibody Response After Vaccination [PDF]

Vaccines
Background: T-cell receptor excision circles (TRECs) and kappa-deleting recombination excision circles (KRECs) are markers of recent thymic and bone marrow output, respectively.
Eline Meyers, Natalja Van Biesen, Liselore De Rop, Tine De Burghgraeve, Marina Digregorio, Laëtitia Buret, Samuel Coenen, Beatrice Scholtes, Jan Y. Verbakel, Stefan Heytens, Piet Cools   +10 more
doaj   +3 more sources

Establishing Simultaneous T Cell Receptor Excision Circles (TREC) and K-Deleting Recombination Excision Circles (KREC) Quantification Assays and Laboratory Reference Intervals in Healthy Individuals of Different Age Groups in Hong Kong [PDF]

Frontiers in Immunology, 2020
The clinical experience gathered throughout the years has raised awareness of primary immunodeficiency diseases (PIDD). T cell receptor excision circles (TREC) and kappa-deleting recombination excision circles (KREC) assays for thymic and bone marrow ...
Janette S. Y. Kwok, Stephen K. F. Cheung, Jenny C. Y. Ho, Ivan W. H. Tang, Patrick W. K. Chu, Eric Y. S. Leung, Pamela P. W. Lee, Daniel K. L. Cheuk, Vincent Lee, Patrick Ip, Y. L. Lau   +10 more
doaj   +2 more sources