Results 11 to 20 of about 4,018 (199)

Beyond TREC: Pivotal role of tandem TREC/KREC assay in Czech SCID NBS pilot programme [PDF]

Pediatric Allergy and Immunology, Volume 36, Issue 5, May 2025.
Severe combined immunodeficiency (SCID) is a fatal but treatable inborn error of immunity (IEI). Newborn screening (NBS) using T‐cell receptor excision circles (TREC) has been adopted globally, with very few countries incorporating kappa recombination ...
Markéta Bloomfield, Eva Hlaváčková, Helena Schneiderová, Marek Turnovec, Lukáš Tichý, Zbyněk Čech, Petr Chrastina, Lenka Dvořáková, Karolína Pešková, Renata Formánková, Petr Říha, Marcela Vlková, Petr Bejdák, Magdaléna Havlišová, Eva Froňková, Tomáš Kalina, Viktor Bíly, Dita Říčná, Hana Grombiříková, Petr Sedláček, Jiří Litzman, Tomáš Freiberger, Anna Šedivá, Adam Klocperk   +23 more
semanticscholar   +3 more sources

Levels of TREC and KREC molecules significance determining in peripheral blood for predicting the outcome of COVID-19 disease in the acute period [PDF]

Russian Journal of Immunology, 2023
The disease caused by the highly contagious SARS-CoV-2 virus novel coronavirus infection (COVID-19) had killed more than 6.5 million people at the end of December 2022.
М. А. Сайтгалина, Yu. V. Ostankova, N. A. Аrsentieva, Zoia R. Korobova, N. E. Liubimova, V. A. Kashchenko, А. Н. Куликов, D. E. Pevtsov, Oksana V. Stanevich, Е. И. Черных, Арег А. Тотолян   +10 more
openalex   +2 more sources

TREC and KREC Levels as a Predictors of Lymphocyte Subpopulations Measured by Flow Cytometry [PDF]

Frontiers in Physiology, 2019
Primary immunodeficiency diseases (PID) is a heterogeneous group of disorders caused by genetic defects of the immune system, which manifests clinically as recurrent infections, autoimmune diseases, or malignancies. Early detection of other PID remains a
Ilya Korsunskiy, Ilya Korsunskiy, Ilya Korsunskiy, Oleg Blyuss, Maria Gordukova, Nataliia Davydova, Nataliia Davydova, Susanna Gordleeva, Robert Molchanov, Alan Asmanov, Dmitrii Peshko, Nataliia Zinovieva, Sergey Zimin, Vladimir Lazarev, Aminat Salpagarova, Maxim Filipenko, Ivan Kozlov, Andrey Prodeus, Andrey Prodeus, Andrey Prodeus, Anatoliy Korsunskiy, Anatoliy Korsunskiy, Peter Hsu, Peter Hsu, Daniel Munblit, Daniel Munblit, Daniel Munblit, Daniel Munblit   +27 more
doaj   +2 more sources

Expanding TREC and KREC Utility in Primary Immunodeficiency Diseases Diagnosis [PDF]

Frontiers in Immunology, 2020
Primary immunodeficiency diseases (PID) area heterogeneous group of disorders caused by genetic defects of the immune system, which manifest clinically as recurrent infections, autoimmune diseases or malignancies.
Ilya Korsunskiy, Ilya Korsunskiy, Oleg Blyuss, Oleg Blyuss, Oleg Blyuss, Maria Gordukova, Natalia Davydova, Alexey Zaikin, Natalia Zinovieva, Sergey Zimin, Robert Molchanov, Aminat Salpagarova, Alina Eremeeva, Maxim Filipenko, Andrey Prodeus, Anatoliy Korsunskiy, Anatoliy Korsunskiy, Peter Hsu, Peter Hsu, Peter Hsu, Daniel Munblit, Daniel Munblit, Daniel Munblit, Daniel Munblit   +23 more
doaj   +2 more sources

Features of the pre-analytical stage in quantitative determination of TREC/KREC in peripheral blood

Медицинская иммунология, 2023
The use of dried blood spots (DBS) obtained from the heels of infants has many advantages over the collection of whole blood samples. DNA extracted from DBS can be used to detect genetic diseases by PCR, which has contributed to the development of ...
M. A. Saitgalina, Yu. V. Ostankova, A. V. Sedykh, A. A. Totolian   +3 more
doaj   +2 more sources

Proof-of-concept study evaluating humoral primary immunodeficiencies via CJ:KREC ratio and serum BAFF level. [PDF]

Sci Rep
Humoral primary immunodeficiencies are the most prevalent form of primary immunodeficiency (PID). Currently, there is no convenient method to quantify newly formed B cells.
Ochfeld E, Khojah A, Marin W, Morgan G, Pachman LM.   +4 more
europepmc   +2 more sources

Primer estudio piloto para el tamizaje neonatal de linfopenias T y B en Colombia [PDF]

Biomédica: revista del Instituto Nacional de Salud
Introducción. La detección temprana de linfopenias congénitas facilitaría su tratamiento oportuno y la prevención de complicaciones serias, y optimizaría los recursos del sistema de salud. Objetivo. Realizar un estudio piloto para el tamizaje neonatal de
Sebastián Gutiérrez-Hincapié, Carlos Muskus-López, Isaura Pilar Sánchez, José Luis Franco-Restrepo, Claudia M. Trujillo-Vargas   +4 more
doaj   +2 more sources

Determination of reference values for TREC and KREC in circulating blood of the persons over 18 years

Медицинская иммунология, 2022
Increasing attention is being paid to methods for detecting primary and secondary T and/or B cell immunodeficiencies. Their implementation into laboratory diagnostics would contribute to the early diagnostics of immunodeficiencies.
M. A. Saitgalina, N. E. Liubimova, Yu. V. Ostankova, R. N. Kuznetzova, A. A. Totolian   +4 more
doaj   +3 more sources

DETERMINATION OF REFERENCE VALUES FOR TREC AND KREC IN DRY BLOOD SPOTS OF NEWBORNS FROM DIFFERENT GESTATION AGES IN SVERDLOVSK REGION

Медицинская иммунология, 2018
As a preparatory stage for implementation of genetic testing for severe combined immunodeficiency under a neonatal screening program, a study was performed in Sverdlovsk Region which concerned quantitative determination of T and B cell neogenesis markers
S. S. Deryabina, I. A. Tuzankina, V. N. Shershnev   +2 more
doaj   +3 more sources

Analysis of the TREC and KREC Levels in the Dried Blood Spots of Healthy Newborns with Different Gestational Ages and Weights [PDF]

Acta Naturae, 2022
Inborn errors of immunity can be detected by evaluating circular DNA (cDNA) fragments of T- and B-cell receptors (TREC and KREC) resulting from the receptor gene rearrangement in T and B cells.
D. A. Cheremokhin, Khyber Shinwari, S. S. Deryabina, Mikhail A. Bolkov, Irina A. Tuzankina, D.А. Kudlаy   +5 more
openalex   +2 more sources