Results 21 to 30 of about 3,703 (207)

Recombination Excision Circle (KREC) Immunoglobulin Gene Rearrangement Mechamism and Importance in Transplants [PDF]

Turkish Journal of Immunology, 2021
Zeynep Akbulut, Gülderen Yanıkkaya Demirel   +1 more
openalex   +2 more sources

TREC and KREC as prognostic markers of HIV infection and COVID-19

Tuberculosis and Lung Diseases, 2022
In some infectious diseases, the number of T- and B-lymphocytes is significantly reduced which is associated with a high risk of the disease progression. The article reviews the effect of two RNA-containing viruses on the specific immune system: SARS-CoV-2 and HIV, as well as parameters of T- and B-cell neogenesis of TREC and KREC, which are markers of
E. I. Veselova, O. V. Lovаchevа, А. G. Samoylova, D.А. Kudlаy, Grigory Kaminskiy   +4 more
openalex   +4 more sources

99P Quantitative indicators of TREC and KREC excision rings in malignant neoplasms [PDF]

ESMO Open, 2023
A.V. Sultanbaev, S. Musin, K. Menshikov, N. Sultanbaevа, I. Menshikova, A. Fatikhova, M. Sultanbaev, V. E. Askarov, D. Kudlay   +8 more
openalex   +2 more sources

Evaluation of TREC/KREC levels in HIV-infected individuals

HIV Infection and Immunosuppressive Disorders
The aim of this study was to evaluate TREC and KREC levels in HIV-infected individuals.Materials and methods. The study material was whole blood samples obtained from HIV-infected individuals with less than one year of infection (n=50) and long-term patients with high viral load and virological failure of ART (n=50).
Yu. V. Ostankova, М. А. Сайтгалина, N. A. Аrsentieva, Арег А. Тотолян   +3 more
openalex   +3 more sources

Harmonizing TREC Thresholds in Newborn Screening for SCID: Insights From Russian Validation Cohort. [PDF]

J Clin Lab Anal
Refining TREC cutoff values in newborn screening (NBS) for SCID: ROC analysis of a large testing cohort supports increasing the TREC threshold from 100 to 150–200 copies/105 cells, improving assay sensitivity and enabling earlier detection of SCID and other immunodeficiencies.
Marakhonov A, Kalinina E, Larin S, Khadzhieva M, Dudina E, Mukhina A, Rodina Y, Efimova I, Balinova N, Sermyagina I, Shchagina O, Zinchenko R, Voronin S, Shcherbina A, Kutsev S.   +14 more
europepmc   +2 more sources

A minimal physiologically-based pharmacokinetic modeling platform to predict intratumor exposure and receptor occupancy of an anti-LAG-3 monoclonal antibody. [PDF]

CPT Pharmacometrics Syst Pharmacol
Abstract In oncology drug development, measuring drug concentrations at the tumor site and at the targeted receptor remains an ongoing challenge. Positron emission tomography (PET)‐imaging is a promising noninvasive method to quantify intratumor exposure of a radiolabeled drug (biodistribution data) and target saturation by treatment doses in vivo ...
Michelet R, Petersson K, Huisman MC, Menke-van der Houven van Oordt CW, Miedema IHC, Thiele A, Montaseri G, Pérez-Pitarch A, Busse D.   +8 more
europepmc   +2 more sources

Differentiating Creatine and Phosphocreatine In Vivo Using 3 T ¹H MR Spectroscopy. [PDF]

Magn Reson Med
ABSTRACT Purpose Validation and improvements to the proton MR spectroscopic measurement of creatine and phosphocreatine in vivo at 3 T. Methods Spectral simulations were used to evaluate and explore the mitigation of LCModel fitting bias due to lineshape, signal‐to‐noise (SNR) and non‐metabolite backgrounds with a focus on phosphocreatine and the ...
Hurd RE, Gu M, Adamson PM, Okamura K, Shibata M, Ono Y, Haidar M, Riemer K, Hanley FL, Spielman DM.   +9 more
europepmc   +2 more sources

Case report: IKZF1-related early-onset CID is expected to be missed in TREC-based SCID screening but can be identified by determination of KREC levels. [PDF]

Front Immunol, 2023
Äng C, Zetterström RH, Ramme K, Axelsen E, Marits P, Sundin M.   +5 more
europepmc   +3 more sources

UTILIZATION OF TREC AND KREC QUANTIFICATION FOR IMMUNE DEFICIENCIES RESEARCH IN MOLDOVA

Biological Markers in Fundamental and Clinical Medicine (collection of abstracts), 2019
UTILIZATION OF TREC AND KREC QUANTIFICATION FOR IMMUNE DEFICIENCIES RESEARCH IN ...
Alexandr DORIF, L. Andries, Victoria Sacara, M. Filipenco   +3 more
openalex   +3 more sources

Five Years of Combined Newborn Screening Quantifying TREC and KREC in Switzerland

The Journal of Allergy and Clinical Immunology: In Practice
Maarja Soomann, Seraina Prader, Susanna H.M. Sluka, Camille Boucq, Jana Pachlopnik Schmid, Johannes Trück, Tiphaine Arlabosse, Felicitas Bellutti Enders, Géraldine Blanchard-Rohner, Michael Buettcher, Vincenzo Cannizzaro, Andrea Duppenthaler, Marco Fischer, Christian R. Kahlert, Lisa Kottanattu, Ines Mack, Reta Malär, Nicole Ritz, Nina Schöbi, Katerina Theodoropoulou   +19 more
  +5 more sources