Results 21 to 30 of about 4,169 (220)

Newborn screening for SCID and severe T- and B-cell lymphopenia in Ukraine: the first analysis of the results, 2022–2025 [PDF]

Frontiers in Immunology
IntroductionSevere combined immunodeficiency (SCID) and other profound T- and B-cell lymphopenias are life-threatening conditions that benefit from early diagnosis and treatment.
Oksana Boyarchuk, Halyna Makukh, Alla Volokha, Alla Volokha, Anastasiia Bondarenko, Anastasiia Bondarenko, Nataliia Mytsyk, Oksana Barvinska, Ivanna Shymanska, Yuliia Pohuliai, Mykola Veropotvelyan, Anastasia Haviley, Marharyta Hurina, Yaryna Romanyshyn, Maryna Trophymova, Iryna Hrabovska, Oksana Malko, Tetiana Tsanko, Oksana Tykholaz, Oleksandr Lysytsia, Nataliia Samonenko, Nataliia Olkhovych   +21 more
doaj   +2 more sources

Primer estudio piloto para el tamizaje neonatal de linfopenias T y B en Colombia [PDF]

Biomédica: revista del Instituto Nacional de Salud
Introducción. La detección temprana de linfopenias congénitas facilitaría su tratamiento oportuno y la prevención de complicaciones serias, y optimizaría los recursos del sistema de salud. Objetivo. Realizar un estudio piloto para el tamizaje neonatal de
Sebastián Gutiérrez-Hincapié, Carlos Muskus-López, Isaura Pilar Sánchez, José Luis Franco-Restrepo, Claudia M. Trujillo-Vargas   +4 more
doaj   +2 more sources

Determination of reference values for TREC and KREC in circulating blood of the persons over 18 years

Медицинская иммунология, 2022
Increasing attention is being paid to methods for detecting primary and secondary T and/or B cell immunodeficiencies. Their implementation into laboratory diagnostics would contribute to the early diagnostics of immunodeficiencies.
M. A. Saitgalina, N. E. Liubimova, Yu. V. Ostankova, R. N. Kuznetzova, A. A. Totolian   +4 more
doaj   +3 more sources

DETERMINATION OF REFERENCE VALUES FOR TREC AND KREC IN DRY BLOOD SPOTS OF NEWBORNS FROM DIFFERENT GESTATION AGES IN SVERDLOVSK REGION

Медицинская иммунология, 2018
As a preparatory stage for implementation of genetic testing for severe combined immunodeficiency under a neonatal screening program, a study was performed in Sverdlovsk Region which concerned quantitative determination of T and B cell neogenesis markers
S. S. Deryabina, I. A. Tuzankina, V. N. Shershnev   +2 more
doaj   +3 more sources

The TREC/KREC assay for the diagnosis and monitoring of patients with DiGeorge syndrome. [PDF]

PLoS ONE, 2014
DiGeorge syndrome (DGS) presents with a wide spectrum of thymic pathologies. Nationwide neonatal screening programs of lymphocyte production using T-cell recombination excision circles (TREC) have repeatedly identified patients with DGS.
Eva Froňková, Adam Klocperk, Michael Svatoň, Michaela Nováková, Michaela Kotrová, Jana Kayserová, Tomáš Kalina, Petra Keslová, Felix Votava, Hana Vinohradská, Tomáš Freiberger, Ester Mejstříková, Jan Trka, Anna Sedivá   +13 more
doaj   +4 more sources

Features of the pre-analytical stage in quantitative determination of TREC/KREC in peripheral blood

Медицинская иммунология, 2023
The use of dried blood spots (DBS) obtained from the heels of infants has many advantages over the collection of whole blood samples. DNA extracted from DBS can be used to detect genetic diseases by PCR, which has contributed to the development of ...
M. A. Saitgalina, Yu. V. Ostankova, A. V. Sedykh, A. A. Totolian   +3 more
doaj   +2 more sources

Photoinactivation vs repair of photosystem II as target of thermal stress in epipelic and epipsammic microphytobenthos communities. [PDF]

PLoS ONE, 2023
Microphytobenthos (MPB) inhabiting intertidal flats are exposed to large and sudden changes in temperature, often simultaneously with exposure to direct sunlight.
Cláudia Bártolo, Silja Frankenbach, João Serôdio   +2 more
doaj   +2 more sources

Proof-of-concept study evaluating humoral primary immunodeficiencies via CJ:KREC ratio and serum BAFF level. [PDF]

Sci Rep
Humoral primary immunodeficiencies are the most prevalent form of primary immunodeficiency (PID). Currently, there is no convenient method to quantify newly formed B cells.
Ochfeld E, Khojah A, Marin W, Morgan G, Pachman LM.   +4 more
europepmc   +2 more sources

Increased incidence of abnormal TREC/ KREC levels is revealed in virtually healthy individuals over the post-pandemic period

Медицинская иммунология
The COVID-19 pandemic has posed an unprecedented challenge to global public health. Poor clinical outcomes in COVID-19 were associated with a pathogenic triad of interrelated mechanisms: immune dysregulation, coagulopathy, and secondary immunodeficiency,
A. Yu. Olkhovskaya, Yu. V. Ostankova, M. A. Saitgalina, S. A. Egorova, А. N. Shchemelev, I. V. Drozd, O. B. Zhimbaeva, E. M. Danilova, A. M. Milichkina, N. S. Bashketova, L. V. Buts, Areg A. Totolian   +11 more
doaj   +2 more sources

Evaluation of TREC/KREC levels in HIV-infected individuals

HIV Infection and Immunosuppressive Disorders
The aim of this study was to evaluate TREC and KREC levels in HIV-infected individuals.Materials and methods. The study material was whole blood samples obtained from HIV-infected individuals with less than one year of infection (n=50) and long-term ...
Y. Ostankova, M. A. Saitgalina, N. Arsentieva, A. Totolian   +3 more
semanticscholar   +2 more sources