Effect of Kruppel-like factor 4 on PTZ-induced acute seizure mice. [PDF]
J Cell Mol MedAbstractKruppel‐like factor 4 (Klf4) is a transcription factor that is involved in neuronal regeneration and the development of glutamatergic systems. However, it is unknown whether Klf4 is involved in acute seizure. To investigate the potential role of Klf4 in pentylenetetrazol (PTZ)‐induced seizure, western blotting, immunofluorescence, behaviour ...
Li B +6 more
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Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner. [PDF]
Mol Cell Proteomics, 2021 Prostate cancer (PCa) is the most frequently diagnosed cancer in men and the third cause of cancer mortality. PCa initiation and growth are driven by the androgen receptor (AR). The AR is activated by androgens such as testosterone and controls prostatic cell proliferation and survival.
Vélot L +11 more
europepmc +4 more sources
Kruppel-Like Factor 4 (KLF4) and its Regulation on Mitochondrial Homeostasis. [PDF]
J Stem Cell Res Ther, 2018 Mitochondria are vital organelles that supply ATP and other energy metabolites to meet the bioenergetics demands of the cell. In environments of stress or increased energy requirement, mitochondria are highly dynamic and can undergo biogenesis, fusion/fission, or autophagy.
Tung B, Xia S.
europepmc +3 more sources
Kruppel-like Factor 4 Regulates Endothelial Inflammation [PDF]
Journal of Biological Chemistry, 2007 The vascular endothelium plays a critical role in vascular homeostasis. Inflammatory cytokines and non-laminar blood flow induce endothelial dysfunction and confer a pro-adhesive and pro-thrombotic phenotype. Therefore, identification of factors that mediate the effects of these stimuli on endothelial function is of considerable interest.
Robert E Gerzsten +9 more
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Kruppel-like factor 4 regulates neutrophil activation [PDF]
Blood Advances, 2017 Key Points KLF4 deficiency impairs neutrophil function in vitro and in vivo. This is the first demonstration that KLF4 plays a crucial role in neutrophils.
Yuyan Shen +8 more
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KLF4 (Kruppel-like factor 4 (gut)) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on KLF4 (Kruppel-like factor 4 (gut)), with data on DNA, on the protein encoded, and where the gene is implicated.
Ghaleb, AM, Yang, VW
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Opposing effects of Kruppel-like factor 4 (gut-enriched Kruppel-like factor) and Kruppel-like factor 5 (intestinal-enriched Kruppel-like factor) on the promoter of the Kruppel-like factor 4 gene [PDF]
Nucleic Acids Research, 2002 KLF4 (Krüppel-like factor 4 or gut-enriched Krüppel-like factor, GKLF) and KLF5 (Krüppel-like factor 5 or intestinal-enriched Krüppel-like factor, IKLF) are two closely related members of the zinc finger-containing Krüppel-like factor family of transcription factors.
Channing S. Mahatan +4 more
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Kruppel-like Factor 4 Is a Mediator of Proinflammatory Signaling in Macrophages [PDF]
Journal of Biological Chemistry, 2005 Activation of macrophages is important in chronic inflammatory disease states such as atherosclerosis. Proinflammatory cytokines such as interferon-gamma (IFN-gamma), lipopolysaccharide (LPS), or tumor necrosis factor-alpha can promote macrophage activation.
Mukesh K. Jain +5 more
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Kruppel-Like Factor 4 Is Essential for Inflammatory Monocyte Differentiation In Vivo. [PDF]
Blood, 2007 Abstract Several members of the Kruppel-like factor (KLF) family of transcription factors play important roles in differentiation, survival, and trafficking of blood and immune cell types. We demonstrate here that hematopoietic cells from KLF4−/− fetal livers (FL) contained normal numbers of functional hematopoietic progenitor cells ...
Ian M. Kaplan +8 more
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Endothelial Kruppel-like factor 4 protects against atherothrombosis in mice [PDF]
Journal of Clinical Investigation, 2012 The endothelium regulates vascular homeostasis, and endothelial dysfunction is a proximate event in the pathogenesis of atherothrombosis. Stimulation of the endothelium with proinflammatory cytokines or exposure to hemodynamic-induced disturbed flow leads to a proadhesive and prothrombotic phenotype that promotes atherothrombosis. In contrast, exposure
Hong Shi +19 more
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