Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis [PDF]
Nature Communications, 2018 While being known as a transcription factor, Kruppel-like factor 4 (Klf4) may have other molecular functions. This study shows that Klf4 in neural progenitor cells regulate neurogenesis and self-renewal by interacting with RNA-binding protein Staufen1 ...
Byoung-San Moon +5 more
doaj +5 more sources
Krüppel-like factor 4 control of immune cell function [PDF]
Frontiers in ImmunologyKrüppel-like factor 4 (KLF4) belongs to a family of transcription factors that contain conserved zinc finger DNA binding domains, including specificity proteins (SPs) and Krüppel-like factors (KLFs).
Tapatee Das +6 more
doaj +3 more sources
Mocetinostat activates Krüppel-like factor 4 and protects against tissue destruction and inflammation in osteoarthritis [PDF]
JCI Insight, 2023 Osteoarthritis (OA) is the most common joint disorder, and disease-modifying OA drugs (DMOADs) represent a major need in OA management. Krüppel-like factor 4 (KLF4) is a central transcription factor upregulating regenerative and protective functions in ...
Manabu Kawata +6 more
doaj +3 more sources
A requirement for Krüppel Like Factor‐4 in the maintenance of endothelial cell quiescence [PDF]
Frontiers in Cell and Developmental Biology, 2022 Rationale and Goal: Endothelial cells (ECs) are quiescent and critical for maintaining homeostatic functions of the mature vascular system, while disruption of quiescence is at the heart of endothelial to mesenchymal transition (EndMT) and tumor ...
Victoria Mastej +4 more
doaj +3 more sources
Deletion of Krüppel-like factor-4 promotes axonal regeneration in mammals [PDF]
Neural Regeneration Research, 2021 Axonal regeneration plays an important role in functional recovery after nervous system damage. However, after axonal injury in mammals, regeneration is often poor.
Jin-Hui Xu +9 more
doaj +3 more sources
Transcription factors Krüppel-like factor 4 and paired box 5 regulate the expression of the Grainyhead-like genes. [PDF]
PLoS ONE, 2021 Genes from the Grainyhead-like (GRHL) family code for transcription factors necessary for the development and maintenance of various epithelia. These genes are also very important in the development of many types of cancer. However, little is known about
Grzegorz Kotarba +4 more
doaj +3 more sources
Mesenchymal Mycn participates in odontoblastic lineage commitment by regulating Krüppel-like Factor 4 (Klf4) in mice [PDF]
Stem Cell Research & Therapy, 2022 Background Commitment of mouse dental papilla cells (mDPCs) to the odontoblast lineage is critical for dentin formation, and this biological process is regulated by a complex transcription factor network. The transcription factor Mycn is a proto-oncogene
Zhuo Huang +6 more
doaj +3 more sources
Induction of Krüppel-Like Factor 4 Mediates Polymorphonuclear Neutrophil Activation in Streptococcus pneumoniae Infection [PDF]
Frontiers in Microbiology, 2021 The recruitment and activation of polymorphonuclear neutrophils (PMNs) are of central importance for the elimination of pathogens in bacterial infections.
Aritra Bhattacharyya +8 more
doaj +3 more sources
Decreased Krüppel-like factor 4 in adenomyosis impairs decidualization by repressing autophagy in human endometrial stromal cells [PDF]
BMC Molecular and Cell Biology, 2022 Background Poor decidualization and abnormal autophagy conditions in the endometria of adenomyosis patients have been reported previously. However, the specific regulatory mechanism of decidualization in adenomyosis and its relationship with autophagy ...
Jie Mei +9 more
doaj +3 more sources
Involvement of miRNA-34a regulated Krüppel-like factor 4 expression in hyperoxia-induced senescence in lung epithelial cells [PDF]
Respiratory Research, 2022 Background Premature infants, subjected to supplemental oxygen and mechanical ventilation, may develop bronchopulmonary dysplasia, a chronic lung disease characterized by alveolar dysplasia and impaired vascularization.
Hajime Maeda +5 more
doaj +3 more sources