Results 91 to 100 of about 723,697 (239)

KLF4 and CD55 expression and function depend on each other

Frontiers in Immunology
The transcription factor Kruppel-like factor 4 (KLF4) regulates the expression of immunosuppressive and anti-thrombotic proteins. Despite its importance in maintaining homeostasis, the signals that control its expression and the mechanism of its ...
Feng-Qi An, Guangjin Zhou, Micah T. Harland, Wasim Hussain, Michael G. Strainic, Mukesh K. Jain, M. Edward Medof   +6 more
doaj   +1 more source

GINS complex subunit 4, a prognostic biomarker and reversely mediated by Krüppel-like factor 4, promotes the growth of colorectal cancer. [PDF]

Cancer Sci, 2020
GINS complex subunit 4 (GINS4) is essential for DNA replication initiation and elongation in the G1/S phase cell cycle in eukaryotes, however, its functional roles and molecular mechanisms remain unclear in many aspects.
Rong Z, Luo Z, Zhang J, Li T, Zhu Z, Yu Z, Fu Z, Qiu Z, Huang C.   +8 more
europepmc   +2 more sources

Recent advances of nanomaterials in imaging liver fibrosis

BMEMat, EarlyView.
Schematic summary on the latest strategies of liver fibrosis imaging based on various nanomaterials. Abstract Liver fibrosis is a pathological process resulting from prolonged exposure to various injury factors. It is characterized by the abnormal proliferation and activation of hepatic stellate cells and excessive deposition of extracellular matrix ...
Jin Cui, Shuxuan Zhang, Xueli Xu, Ke Ren, Mengzhen Dong, Zhaokun Nie, Yang Xu, Xiaohui Dai, Peng Xu, Shuo Sun, Xinya Zhao, Xiao Sun   +11 more
wiley   +1 more source

The Gut-enriched Krüppel-like Factor (Krüppel-like Factor 4) Mediates the Transactivating Effect of p53 on the p21 Promoter [PDF]

Journal of Biological Chemistry, 2000
An important mechanism by which the tumor suppressor p53 maintains genomic stability is to induce cell cycle arrest through activation of the cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene. We show that the gene encoding the gut-enriched Krüppel-like factor (GKLF, KLF4) is concurrently induced with p21(WAF1/Cip1) during serum deprivation and DNA
Janiel M. Shields, Joseph R. Biggs, Deborah E. Geiman, Channing S. Mahatan, Weiqing Zhang, Klaus H. Kaestner, Andrew S. Kraft, Vincent W. Yang, Duyen T. Dang   +8 more
openaire   +3 more sources

Smooth muscle–derived progenitor cell myofibroblast differentiation through KLF4 downregulation promotes arterial remodeling and fibrosis

JCI Insight, 2020
Resident vascular adventitial SCA1+ progenitor (AdvSca1) cells are essential in vascular development and injury. However, the heterogeneity of AdvSca1 cells presents a unique challenge in understanding signaling pathways orchestrating their behavior in ...
Sizhao Lu, Austin J. Jolly, Keith A. Strand, Allison M. Dubner, Marie F. Mutryn, Karen S. Moulton, Raphael A. Nemenoff, Mark W. Majesky, Mary C.M. Weiser-Evans   +8 more
doaj   +1 more source

Factorizing Numbers with the Gauss Sum Technique: NMR Implementations [PDF]

, 2007
Several physics-based algorithms for factorizing large number were recently published. A notable recent one by Schleich et al. uses Gauss sums for distinguishing between factors and non-factors. We demonstrate two NMR techniques that evaluate Gauss sums and thus implement their algorithm.
arxiv   +1 more source

Metabolic changes during cardiac regeneration in the axolotl

Developmental Dynamics, EarlyView.
Abstract Background The axolotl is a prominent model organism of heart regeneration due to its ability to anatomically and functionally repair the heart after an injury that mimics human myocardial infarction. In humans, such an injury leads to permanent scarring. Cardiac regeneration has been linked to metabolism and the oxygenation state, but so far,
Anita Dittrich, Sofie Amalie Andersson, Morten Busk, Kasper Hansen, Casper Bindzus Foldager, Johan Palmfeldt, Asger Andersen, Michael Pedersen, Mikkel Vendelbo, Kirstine Lykke Nielsen, Henrik Lauridsen   +10 more
wiley   +1 more source

RORα Induces KLF4-Mediated M2 Polarization in the Liver Macrophages that Protect against Nonalcoholic Steatohepatitis

Cell Reports, 2017
The regulation of M1/M2 polarization in liver macrophages is closely associated with the progression of nonalcoholic steatohepatitis (NASH); however, the mechanism involved in this process remains unclear.
Yong-Hyun Han, Hyeon-Ji Kim, Hyelin Na, Min-Woo Nam, Ju-Yeon Kim, Jun-Seok Kim, Seung-Hoi Koo, Mi-Ock Lee   +7 more
doaj   +1 more source

Pathways to Progressive Disability in Multiple Sclerosis: The Role of Glial Cells in Chronic CNS Inflammation

Glia, EarlyView.
ABSTRACT Multiple sclerosis (MS) is the most common non‐infectious inflammatory CNS disease, characterized by progressive neurodegeneration and focal demyelinated lesions. Traditionally considered an autoimmune disease, MS is driven by the immune system's attack on CNS myelin, resulting in cumulative disability.
Volker Siffrin
wiley   +1 more source

MicroRNA-1 Regulates Smooth Muscle Cell Differentiation by Repressing Kruppel-Like Factor 4 [PDF]

Stem Cells and Development, 2011
The role of microRNA-1 (miR-1) has been studied in cardiac and skeletal muscle differentiation. However, it remains unexplored in vascular smooth muscle cells (SMCs) differentiation. The aim of this study was to uncover novel targets of and shed light on the function of miR-1 in the context of embryonic stem cell (ESC) differentiation of SMCs in vitro.
Xie, Changqing, Huang, Huarong, Sun, Xuan, Guo, Yanhong, Hamblin, Milton, Ritchie, Raquel P., Garcia-Barrio, Minerva T., Zhang, Jifeng, Chen, Y. Eugene   +8 more
openaire   +4 more sources