Results 101 to 110 of about 157,775 (261)
Sequence analysis of the cis-regulatory regions of the bithorax complex of Drosophila [PDF]
, 1995 The bithorax complex (BX-C) of Drosophila, one of two complexes that act as master regulators of the body plan of the fly, has now been entirely sequenced and comprises approximate to 315,000 bp, only 1.4% of which codes for protein.
Celniker, Susan E. +3 more
core +1 more source
Epigallocatechin-3-gallate regulates the expression of Kruppel-like factor 4 through myocyte enhancer factor 2A [PDF]
Cell Stress and Chaperones, 2014 Epigallocatechin-3-gallate (EGCG), a powerful antioxidant and free ion scavenger found in green tea, exhibits inhibitory effects on different stages of tumorigenesis. Within gastric cancer cells, the transcription factor Kruppel-like factor 4 (KLF4) is downregulated, and it is possible that EGCG exerts its anti-tumorigenic function through modulation ...
Yuwen, Ma +5 more
openaire +2 more sources
Advanced Science, EarlyView.Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian +5 more
wiley +1 more source
Acta Medica, 2009 Practically all mammalian cells including human can switch, according to micro- or macroenvironmental conditions, from states of cellular quiescence to inflammatory activation and vice versa.
Pavel Kuneš +2 more
doaj +1 more source
Additional Clues for a Protective Role ofVitamin D in Neurodegenerative Diseases: 1,25-Dihydroxyvitamin D3 Triggers an Anti-Inflammatory Response in BrainPericytes [PDF]
, 2014 International audienceEpidemiological and experimental studies suggest that 1,25-dihydroxyvitamin D3 (1,25D) plays a neuroprotectiverole in neurodegenerative diseases including Alzheimer's disease.
Berger, François +5 more
core +3 more sources
Advanced Science, EarlyView.Nap1l4a is required in erythropoiesis and hypoxia responses via physical interaction with Klf1 and Scl to recruit the histone variant H2A.Z. This facilitates its associated cis‐regulatory element (CRE) remodeling and the consequent chromatin assembly, and activates the transcription of erythroid lineage‐specific genes.
JiaHao Shi +10 more
wiley +1 more source
Advanced Science, EarlyView.MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang +12 more
wiley +1 more source
Supplementary Figure 3 from Kruppel-like Factor 4 Induces <i>p27<sup>Kip1</sup></i> Expression in and Suppresses the Growth and Metastasis of Human Pancreatic Cancer Cells [PDF]
, 2023 Daoyan Wei +4 more
openalex +2 more sources
Kruppel-like factor 4 as a therapeutically tractable brake on lung fibroblast activation which promotes resolution of pulmonary fibrosis [PDF]
, 2022 Marc Peters‐Golden +4 more
openalex +1 more source
Journal of Cellular and Molecular Medicine, 2019 Krüppel‐like factor 4 (KLF4) was closely associated with epithelial‐mesenchymal transition and stemness in colorectal cancer stem cells (CSCs)‐enriched spheroid cells. Nonetheless, the underlying molecular mechanism is unclear.
Zhengwei Leng +6 more
semanticscholar +1 more source