Results 141 to 150 of about 723,697 (239)

Hyperhomocysteinemia induces vascular calcification by activating the transcription factor RUNX2 via Krüppel-like factor 4 up-regulation in mice

Journal of Biological Chemistry, 2019
One of the main characteristics of atherosclerosis is vascular calcification, which is linked to adverse cardiovascular events. Increased homocysteine (Hcy), a feature of hyperhomocysteinemia, is correlated with advanced vascular calcification and ...
Lili Zhu, N. Zhang, Ru Yan, Wenzhong Yang, Guangzhi Cong, Ning Yan, Wanrui Ma, Jianjun Hou, Libo Yang, S. Jia   +9 more
semanticscholar   +1 more source

Optimization of Immunotherapy Strategies Based on Spatiotemporal Heterogeneity of Tumour‐Associated Tissue‐Resident Memory T Cells

Immunology, Volume 175, Issue 2, Page 123-133, June 2025.
The tumour microenvironment (TME) and tumour evolution stage lead to temporal and spatial heterogeneity in tumour‐resident macrophages (TRMs), affecting their phenotype and function across different stages and tumour types. While TRMs infiltration is often linked to positive immunotherapy responses and prognosis, some subtypes may negatively impact ...
Yile Shang, Yinjun He, Xiang Zhang, Wenguang He, Hanju Hua, Feng Ye, Xile Zhou, Yandong Li, Weixiang Zhong, Guosheng Wu, Weiqin Jiang   +10 more
wiley   +1 more source

Induction of T‐Cell Differentiation by KLF4 in T‐Cell Acute Lymphoblastic Leukemia Cells Harboring Activating Mutation in NOTCH3

The FASEB Journal, Volume 39, Issue 10, 31 May 2025.
KLF4‐induced T‐cell differentiation and apoptosis in TALL‐1 cells harboring an activating mutation in NOTCH3. KLF4 directly downregulated NOTCH3 expression by binding to its promoter, thereby promoting the differentiation of CD4/CD8 double‐positive cells into CD4 single‐positive cells, with the differentiated cells subsequently undergoing apoptosis ...
Mina Noura, Takahiko Yasuda, Hitoshi Kiyoi, Fumihiko Hayakawa   +3 more
wiley   +1 more source

Role of Krüppel-like Factor 4-p21CIP1 Axis in Breast Cancer Stem-like Cell Inhibition by Benzyl Isothiocyanate

Cancer Prevention Research, 2019
Cancer chemoprevention by benzyl isothiocyanate (BITC), which is derived from cruciferous vegetables like garden cress, in a transgenic mouse model of breast cancer is associated with inhibition of breast cancer stem-like cells (bCSC), but the molecular ...
Su-Hyeong Kim, Shivendra V. Singh
semanticscholar   +1 more source

The factorizations of finite classical groups [PDF]

arXiv
We classify the factorizations of finite classical groups with nonsolvable factors, completing the classification of factorizations of finite almost simple groups.
arxiv  

Alternative splicing of Kruppel‐like factor 4 plays a pivotal role in human tumorigenesis

The FASEB Journal, 2010
Most human genes undergo alternative splicing, and many abnormal splicing processes are associated with disease including cancer. However, the relationship between alternative splicing and tumorigenesis is not well‐understood. Here, we found that novel Kruppel‐like factor 4 (KLF4) splicing variants produced by exon skipping could play a role during ...
Seong-Ho Lee, Jae Hoon Bahn, Seung Joon Baek   +2 more
openaire   +2 more sources

Krüppel-Like Factor 4 Inhibits Pancreatic Cancer Epithelial-to-Mesenchymal Transition and Metastasis by Down-Regulating Caveolin-1 Expression

Cellular Physiology and Biochemistry, 2018
Background/Aims: Krüppel-like factor 4 (KLF4), a member of the KLF family of zinc finger transcription factors, has been identified as a tumor suppressor gene in a variety of tumors.
Zhonglin Zhu, Zhilong Yu, Jianfeng Wang, Lisheng Zhou, Jing Zhang, B. Yao, Jin Dou, Z. Qiu, Chen Huang   +8 more
semanticscholar   +1 more source

SIRT6 drives epithelial-to-mesenchymal transition and metastasis in non-small cell lung cancer via snail-dependent transrepression of KLF4

Journal of Experimental & Clinical Cancer Research, 2018
Background Epithelial-to-mesenchymal transition (EMT) contributes to the invasion and metastasis of epithelial tumors. Sirtuin 6 (SIRT6), an NAD-dependent deacetylase, is known to promote metastasis of non-small cell lung cancer (NSCLC).
Ziming Li, Jia Huang, Shengping Shen, Zhenping Ding, Qingquan Luo, Zhiwei Chen, Shun Lu   +6 more
doaj   +1 more source

On the Form Factor for the Unitary Group [PDF]

arXiv, 2003
We study the combinatorics of the contributions to the form factor of the group U(N) in the large $N$ limit. This relates to questions about semiclassical contributions to the form factor of quantum systems described by the unitary ensemble.
arxiv  

Ovarian Tumor Domain-Containing 7B Attenuates Pathological Cardiac Hypertrophy by Inhibiting Ubiquitination and Degradation of Krüppel-Like Factor 4. [PDF]

J Am Heart Assoc, 2023
Du BB, Zhang JL, Kong LY, Shi HT, Zhang DH, Wang X, Yang CL, Li PC, Yao R, Liang C, Wu LM, Huang Z.   +11 more
europepmc   +1 more source