Kruppel-like factor 4 regulates neutrophil activation [PDF]
Blood Advances, 2017 : Neutrophils are the most abundant white blood cells in circulation and are key components of the innate immune response. Clinical and experimental studies support an important role for the neutrophils in a broad spectrum of acute and chronic ...
Yuyan Shen +7 more
doaj +5 more sources
Genetic and Epigenetic Inactivation of Kruppel-like Factor 4 in Medulloblastoma
Neoplasia: An International Journal for Oncology Research, 2010 Although medulloblastoma is the most common pediatric malignant brain tumor, its molecular underpinnings are largely unknown. We have identified rare, recurrent homozygous deletions of Kruppel-like Factor 4 (KLF4) in medulloblastoma using high-resolution
Yukiko Nakahara +14 more
doaj +4 more sources
MicroRNA-1 Regulates Smooth Muscle Cell Differentiation by Repressing Kruppel-Like Factor 4 [PDF]
Stem Cells and Development, 2010 The role of microRNA-1 (miR-1) has been studied in cardiac and skeletal muscle differentiation. However, it remains unexplored in vascular smooth muscle cells (SMCs) differentiation. The aim of this study was to uncover novel targets of and shed light on
Changqing Xie +8 more
core +8 more sources
Krüppel‐Like Factor 4, a Hub Gate for Cell Crosstalk in Tumor Microenvironment [PDF]
Cancer MedicineObjective Krüppel‐like factor 4 (KLF4) is a zinc finger transcription factor that plays context‐dependent roles in cancer. It functions as either a tumor suppressor or an oncogene depending on tumor type and cellular context.
Min Tang +5 more
doaj +3 more sources
Therapeutic Targeting of Krüppel-Like Factor 4 and Its Pharmacological Potential in Parkinson's Disease: a Comprehensive Review. [PDF]
Mol Neurobiol, 2023 Krüppel-like factor 4 (KLF4), a zinc finger transcription factor, is found in different human tissues and shows diverse regulatory activities in a cell-dependent manner.
Zamanian MY +9 more
europepmc +2 more sources
Inhibition of miR-25 Ameliorates Cardiac Dysfunction and Fibrosis by Restoring Krüppel-like Factor 4 Expression. [PDF]
Int J Mol Sci, 2023 Cardiac hypertrophy is an adaptive response to various pathological insults, including hypertension. However, sustained hypertrophy can cause impaired calcium regulation, cardiac dysfunction, and remodeling, accompanied by cardiac fibrosis.
Lee C, Cho S, Jeong D.
europepmc +2 more sources
Krüppel-like factor 4 regulates the cytolytic effector function of exhausted CD8 T cells. [PDF]
Sci Adv, 2022 Exhausted CD8 T cells during chronic inflammatory responses against viral infections and cancer are phenotypically and functionally heterogeneous.
Nah J, Seong RH.
europepmc +2 more sources
Extracellular vesicles from 3D cultured dermal papilla cells improve wound healing via Krüppel-like factor 4/vascular endothelial growth factor A -driven angiogenesis. [PDF]
Burns Trauma, 2023 Background Non-healing wounds are an intractable problem of major clinical relevance. Evidence has shown that dermal papilla cells (DPCs) may regulate the wound-healing process by secreting extracellular vesicles (EVs).
Wang Y +17 more
europepmc +2 more sources
Six Shades of Vascular Smooth Muscle Cells Illuminated by KLF4 (Krüppel-Like Factor 4). [PDF]
Arterioscler Thromb Vasc Biol, 2021 Multiple layers of vascular smooth muscle cells (vSMCs) are present in blood vessels forming the media of the vessel wall. vSMCs provide a vessel wall structure, enabling it to contract and relax, thus modulating blood flow. They also play a crucial role
Yap C +4 more
europepmc +2 more sources
MicroRNA-146a Promotes Embryonic Stem Cell Differentiation towards Vascular Smooth Muscle Cells through Regulation of Kruppel-like Factor 4. [PDF]
Curr Med Sci, 2023 Objective Vascular smooth muscle cell (VSMC) differentiation from stem cells is one source of the increasing number of VSMCs that are involved in vascular remodeling-related diseases such as hypertension, atherosclerosis, and restenosis.
Zhang Q, Pan RR, Wu YT, Wei YM.
europepmc +2 more sources