Results 11 to 20 of about 723,697 (239)

Genetic and Epigenetic Inactivation of Kruppel-like Factor 4 in Medulloblastoma

Neoplasia, 2010
Although medulloblastoma is the most common pediatric malignant brain tumor, its molecular underpinnings are largely unknown. We have identified rare, recurrent homozygous deletions of Kruppel-like Factor 4 (KLF4) in medulloblastoma using high-resolution single nucleotide polymorphism arrays, digital karyotyping, and genomic real-time polymerase chain ...
Young Shin Ra, Wesia Grajkowska, Charles G. Eberhart, Timothy E. Van Meter, Yukiko Nakahara, Meihua Li, Paul Kongkham, Hai Yan, Darrell D. Bigner, Annie Huang, Paul A. Northcott, James T. Rutka, Christian A. Smith, Sidney Croul, Michael D. Taylor   +14 more
openaire   +5 more sources

Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis [PDF]

Nature Communications, 2018
AbstractKruppel-like factor 4 (Klf4) is a zinc-finger-containing protein that plays a critical role in diverse cellular physiology. While most of these functions attribute to its role as a transcription factor, it is postulated that Klf4 may play a role other than transcriptional regulation. Here we demonstrate that Klf4 loss in neural progenitor cells
Byoung-San Moon, Jinlun Bai, Mingyang Cai, Chunming Liu, Jiandang Shi, Wange Lu   +5 more
openaire   +4 more sources

Mocetinostat activates Krüppel-like factor 4 and protects against tissue destruction and inflammation in osteoarthritis. [PDF]

JCI Insight, 2023
Osteoarthritis (OA) is the most common joint disorder, and disease-modifying OA drugs (DMOADs) represent a major need in OA management. Krüppel-like factor 4 (KLF4) is a central transcription factor upregulating regenerative and protective functions in ...
Kawata M, McClatchy DB, Diedrich JK, Olmer M, Johnson KA, Yates JR, Lotz MK.   +6 more
europepmc   +2 more sources

Inhibition of miR-25 Ameliorates Cardiac Dysfunction and Fibrosis by Restoring Krüppel-like Factor 4 Expression. [PDF]

Int J Mol Sci, 2023
Cardiac hypertrophy is an adaptive response to various pathological insults, including hypertension. However, sustained hypertrophy can cause impaired calcium regulation, cardiac dysfunction, and remodeling, accompanied by cardiac fibrosis.
Lee C, Cho S, Jeong D.
europepmc   +2 more sources

Krüppel-like factor 4 regulates the cytolytic effector function of exhausted CD8 T cells. [PDF]

Sci Adv, 2022
Exhausted CD8 T cells during chronic inflammatory responses against viral infections and cancer are phenotypically and functionally heterogeneous.
Nah J, Seong RH.
europepmc   +2 more sources

Extracellular vesicles from 3D cultured dermal papilla cells improve wound healing via Krüppel-like factor 4/vascular endothelial growth factor A -driven angiogenesis. [PDF]

Burns Trauma, 2023
Background Non-healing wounds are an intractable problem of major clinical relevance. Evidence has shown that dermal papilla cells (DPCs) may regulate the wound-healing process by secreting extracellular vesicles (EVs).
Wang Y, Shen K, Sun Y, Cao P, Zhang J, Zhang W, Liu Y, Zhang H, Chen Y, Li S, Xu C, Han C, Qiao Y, Zhang Q, Wang B, Luo L, Yang Y, Guan H.   +17 more
europepmc   +2 more sources

Six Shades of Vascular Smooth Muscle Cells Illuminated by KLF4 (Krüppel-Like Factor 4). [PDF]

Arterioscler Thromb Vasc Biol, 2021
Multiple layers of vascular smooth muscle cells (vSMCs) are present in blood vessels forming the media of the vessel wall. vSMCs provide a vessel wall structure, enabling it to contract and relax, thus modulating blood flow. They also play a crucial role
Yap C, Mieremet A, de Vries CJM, Micha D, de Waard V.   +4 more
europepmc   +2 more sources

Therapeutic Targeting of Krüppel-Like Factor 4 and Its Pharmacological Potential in Parkinson's Disease: a Comprehensive Review. [PDF]

Mol Neurobiol, 2023
Krüppel-like factor 4 (KLF4), a zinc finger transcription factor, is found in different human tissues and shows diverse regulatory activities in a cell-dependent manner.
Zamanian MY, Golmohammadi M, Amin RS, Bustani GS, Romero-Parra RM, Zabibah RS, Oz T, Jalil AT, Soltani A, Kujawska M.   +9 more
europepmc   +2 more sources

Krüppel-like factor 4 modulates the miR-101/COL10A1 axis to inhibit renal fibrosis after AKI by regulating epithelial-mesenchymal transition. [PDF]

Ren Fail
Acute kidney injury (AKI) can progress to renal fibrosis and chronic kidney disease (CKD), which reduces quality of life and increases the economic burden on patients.
Zhao J, Wang X, Wu Y, Zhao C.
europepmc   +2 more sources

A requirement for Krüppel Like Factor-4 in the maintenance of endothelial cell quiescence. [PDF]

Front Cell Dev Biol, 2022
Rationale and Goal Endothelial cells (ECs) are quiescent and critical for maintaining homeostatic functions of the mature vascular system, while disruption of quiescence is at the heart of endothelial to mesenchymal transition (EndMT) and tumor ...
Mastej V, Axen C, Wary A, Minshall RD, Wary KK.   +4 more
europepmc   +2 more sources