Results 191 to 200 of about 723,697 (239)

Regulation and Function of the Cancer Stem Cell Transcription Factors GLI1 and Kruppel-like Factor 4

, 2019
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Role of Kruppel-like factor 4 in atherosclerosis

Clinica Chimica Acta, 2021
Atherosclerosis is one of the chronic progressive diseases, which is caused by vascular injury and promoted by the interaction of various inflammatory factors and inflammatory cells. In recent years, kruppel-like factor 4 (KLF4), a significant transcription factor that participated in cell growth, differentiation and proliferation, has been proved to ...
Chen Yang, Xuan Xiao, Liang Huang, Fan Zhou, Lin-hui Chen, Yu-Yan Zhao, Shun-Lin Qu, Chi Zhang   +7 more
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Mechanism of Kruppel-Like Factor 4 in Pyroptosis of Nasal Mucosal Epithelial Cells in Mice With Allergic Rhinitis

American Journal of Rhinology & Allergy, 2023
Background Allergic rhinitis (AR) is a chronic nasal inflammation, characterized by nasal epithelial dysfunction. Gene therapy targeting transcription factors is a promising strategy for quenching allergic inflammation, including AR. Objective This study
Jiaoli Yao, Qingfeng Kong, Yin Wang, Yanting Zhang, Qinxue Wang   +4 more
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Exposure to MoS2 nanosheets or bulk activated Kruppel‐like factor 4 in 3D Caco‐2 spheroids in vitro and mouse intestines in vivo

Environmental Toxicology, 2023
MoS2 nanosheets (NSs) are novel 2D nanomaterials (NMs) being used in many important fields. Recently, we proposed the need to evaluate the influences of NMs on Kruppel‐like factors (KLFs) even if these materials are relatively biocompatible.
You Xiao, Yuan He, Chongsi Xu, Mei Li, Fan Hu, Wen Wang, Zhenquan Wang, Yi Cao   +7 more
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Kruppel-like factor 4 regulates keratinocyte senescence

Biochemical and Biophysical Research Communications, 2018
Keratinocyte replicative senescence has an important role in time-related changes of epidermis. Previous studies demonstrated that miRNAs play key roles in inhibiting proliferation and in the acquisition of the keratinocyte senescent phenotype as well as in individual ageing.
PANATTA, EMANUELE, Lena, A. M, MANCINI, MARA, Affinati, M, SMIRNOV, ARTEM, Annicchiarico-Petruzzelli, M, Piro, M. C, Campione, E, Bianchi, L, Mazzanti, C, Melino, G, Candi, E   +11 more
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44 KRUPPEL-LIKE FACTOR 4 REGULATES ENDOTHELIAL INFLAMMATION. [PDF]

Journal of Investigative Medicine, 2007
Background The vascular endothelium plays a critical role in vascular homeostasis. A limited proinflammatory, prothrombotic state is appropriate in the context of infection or wound healing, but sustained endothelial activation leads to deleterious conditions such as atherosclerosis and pathologic thrombosis.
Mukesh K. Jain, R. E. Gerzsten, S. Sinha, J. Katz, Z. Lin, M. Balcells, A. Kumar, E. R. Edelman, A. Hamik   +8 more
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Kruppel‐like Factor 4 is Critical to the Maintenance of Glomerular Endothelial Integrity

The FASEB Journal, 2020
BackgroundThrombotic microangiopathy (TMA) represents the most severe manifestation of glomerular endothelial injury consisting of endothelial cell (EC) swelling, subendothelial expansion, inflammation and microthrombi. TMA occurs subsequent to various etiologies and is associated with dysregulation of thrombotic and inflammatory transcripts and ...
Monica P. Revelo, Chelsea Estrada, Sandeep K. Mallipattu   +2 more
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Berberine improves dietary-induced cardiac remodeling by upregulating Kruppel-like factor 4-dependent mitochondrial function

Biological chemistry, 2021
Multiple studies have showed that berberine protects against heart diseases, including obesity-associated cardiomyopathy. However, it is not fully disclosed the potential molecular mechanisms of berberine on controlling cardiac remodeling.
Laili Ding, Shufeng Li, Fan Wang, Jian Xu, Shaojun Li, Bo Wang, J. Kou, Yongshun Wang, Wei Cao   +8 more
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Roles of Kruppel-like factor 4 in oesophageal epithelial cells in Barrett's epithelium development [PDF]

Gut, 2010
The mechanism of transformation to intestinal metaplasia in Barrett's oesophagus has not been clarified. We previously reported that bile acids activate the Cdx2 promoter via nuclear factor kappa B (NF-κB) and stimulate production of Cdx2 protein in oesophageal keratinocytes, resulting in production of intestinal-type mucin. Krüppel-like factor 4 (KLF4)
Yuji Amano, Hideaki Kazumori, Yoshikazu Kinoshita, Yoshiko Takahashi, Shunji Ishihara   +4 more
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Effect of Kruppel-like factor 4 on Notch pathway in hepatic stellate cells

Journal of Huazhong University of Science and Technology [Medical Sciences], 2016
The relationship between Kruppel-like factor 4 (KLF4) and the Notch pathway was determined to investigate the effect of KLF4 on the activation of hepatic stellate cells and underlying mechanisms. Fifty SPF BALB/c mice were randomly divided into two groups. A liver fibrosis model was established in 25 mice as the experimental group, and the remaining 25
Lu-Jia Chen, Li-Bo Chen, Yin-kai Xue, Huan-ping Ren, Jun Tan, Xin-gao Xiong, Hai Zheng, Dongwei Dou, Ding Chen   +8 more
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