Results 201 to 210 of about 723,697 (239)

Kruppel-Like Factor 4 represses osteoblast differentiation via ciliary Hedgehog signaling

Experimental Cell Research, 2018
Primary cilia are appendages observed in most types of cells, and serve as cellular antennae for sensing environmental signals. Evidence is accumulating that correct ciliogenesis and ciliary functions are indispensable for normal skeletal development by regulating signaling pathways important for bone development.
Makoto Abe, Shigehisa Akiyama, Takashi Yamashiro, Kadry Mahamed Sadek, Shousaku Itoh, Akiyoshi Kito, Satoshi Wakisaka, Junji Fujikawa, Yuto Takeuchi, Haruna Naruse   +9 more
openaire   +3 more sources

MicroRNA (miR)-429 promotes inflammatory injury by targeting kruppel-like factor 4 (KLF4) in neonatal pneumonia.

Current Neurovascular Research, 2020
BACKGROUND Neonatal pneumonia is a common disease in the neonatal period with a high incidence and death. This study aimed to investigate the molecular mechanism and effect of microRNA (miR)-429 in neonatal pneumonia.
Lan Zhang, Huibo Yan, Huiping Wang, Li Wang, Boling Bai, Yingjun Ma, Y. Tie, Zhaoxia Xi   +7 more
semanticscholar   +1 more source

MiR-32 promotes gastric carcinoma tumorigenesis by targeting Kruppel-like factor 4

Biochemical and Biophysical Research Communications, 2015
Gastric cancer (GC) is a prevalent malignant cancer worldwide and is highly lethal because of its fast growth. Currently, the clinical therapy options for GC remain limited. MiR-32 has been reported as an oncogenic microRNA in many cancers, but its role in GC is unclear.
Li Zhou, Chao Yan, Weiming Kang, Yu-Qin Liu, Zhi-Qiang Ma, Jian-Chun Yu   +5 more
openaire   +3 more sources

Kruppel-like factor 4 expression in osteoblasts represses osteoblast-dependent osteoclast maturation

Cell and Tissue Research, 2014
Kruppel-like factor 4 (KLF4) is a zinc-finger-type transcription factor with a restricted expression pattern during skeletal development. We have previously shown that KLF4 represses osteoblast mineralization concomitant with a down-regulation in the expression of a number of osteoblastic genes, both in vivo and in vitro.
Makoto Abe, Mariko Tanaka, Ichijiro Morisaki, Toshiya Fukushi, Kojiro Kurisu, Shousaku Itoh, Satoshi Wakisaka, Yuto Takeuchi, Junji Fujikawa   +8 more
openaire   +2 more sources

Downregulation of miR-34a ameliorates inflammatory response and apoptosis induced by renal ischemia-reperfusion by promoting Kruppel-like factor 4 expression.

European Review for Medical and Pharmacological Sciences, 2020
OBJECTIVE To explore the influence of micro ribonucleic acid (miR)-34a on renal ischemia-reperfusion by regulating Kruppel-like factor 4 (KLF4). MATERIALS AND METHODS A total of 36 Sprague-Dawley (SD) rats weighing 180-200 g were randomly divided into ...
Y. Shi, MA Y.-H., R. Zhang, LI R.-S., MD Rongshan Li   +4 more
semanticscholar   +1 more source

Kruppel-like factor 4 regulates matrix metalloproteinase and aggrecanase gene expression in chondrocytes

Cell and Tissue Research, 2017
Kruppel-like factor 4 (KLF4) is a zinc finger transcription factor that plays crucial roles during the development and maintenance of multiple organs. We and others have previously shown that KLF4 is involved in bone modeling and remodeling but roles played by KLF4 during skeletogenesis are still not fully understood.
Eman Elkhashab, Satoshi Kanazawa, Makoto Abe, Ichijiro Morisaki, Amr M. Ghaleb, Akiyoshi Kito, Junji Fujikawa, Shigehisa Akiyama, Takashi Yamashiro, Ahmed G. Nomir, Yuto Takeuchi, Vincent W. Yang, Satoshi Wakisaka   +12 more
openaire   +3 more sources

A Preliminary Study of miR-144 Inhibiting the Stemness of Colon Cancer Stem Cells by Targeting Krüppel-Like Factor 4.

Journal of Biomedical Nanotechnology, 2020
Colon cancer is a prevalent clinical malignant tumor of the digestive system. The current study aims to explore the miR-144 expression in colorectal cancer (CRC) cell lines and CRC stem cells (CSCs) and to explore its effect on the stemness of CSCs and ...
Z. Qiu, Lingjing Tu, Xiongwei Hu, Zhi-hang Zhou, Yong-da Lin, L. Ye, Chunhui Cui   +6 more
semanticscholar   +1 more source

Effect of MiR-32 on gastric carcinoma tumorigenesis by targeting Kruppel-like factor 4.

Journal of Clinical Oncology, 2016
76 Background: Gastric cancer (GC) is a prevalent malignant cancer worldwide and is highly lethal because of its fast growth. Currently, the comprehensive treatment is the combination of surgery, chemotherapy and radiotherapy, which has made progress in the treatment of advanced GC.
Chao Yan, Jian-Chun Yu, Weiming Kang
openaire   +2 more sources

MicroRNA‐10b regulates the renewal of spermatogonial stem cells through Kruppel‐like factor 4

Cell Biochemistry and Function, 2017
MicroRNAs (miRs) are functionally important in spermatogenesis, which is the self‐renewal or differentiation of spermatogonial stem cells (SSCs). Here, we report a novel role for miR‐10b in regulating the self‐renewal of mouse SSCs. We showed that miR‐10b was highly expressed in mouse SSCs in vitro and enhanced SSC proliferation.
Wenzhi Ma, Yanrong Wang, Xiaopeng Hu, Jiang Li, Xiang Liu, Geng G. Tian, Ji Wu, Ji Wu, Pei Xiuying   +8 more
openaire   +3 more sources

Krüppel-like factor 4 (KLF4) facilitates lipid production in immortalized human sebocytes via regulating the expression of SREBP1.

Biochemical and Biophysical Research Communications - BBRC, 2023
Xia Li, Xin Zeng, Doyeon Kim, Jian Jiang, Feng juan Wei, Jing-yu Zhang, Bao Chai, Li Fu, Y. Lee, Chang-Hyeon Kim, Hongxiang Chen   +10 more
semanticscholar   +1 more source