Krüppel-like factor-4 and Krüppel-like factor-2 are important regulators of joint tissue cells and protect against tissue destruction and inflammation in osteoarthritis. [PDF]
Ann Rheum Dis, 2022 Objectives Analysing expression patterns of Krüppel-like factor (KLF) transcription factors in normal and osteoarthritis (OA) human cartilage, and determining functions and mechanisms of KLF4 and KLF2 in joint homoeostasis and OA pathogenesis.
Kawata M +8 more
europepmc +2 more sources
<i>Fusobacterium nucleatum</i> Promotes the Growth and Metastasis of Colorectal Cancer by Activating E-Cadherin/Krüppel-Like Factor 4/Integrin α5 Signaling in a Calcium-Dependent Manner. [PDF]
MedComm (2020)Gut microbiota and integrins are known to contribute to colorectal cancer (CRC), but whether they interact has been unclear. Here, we provided evidence that Fusobacterium nucleatum upregulated integrin α5 (ITGA5) in CRC in both human patients and murine ...
Yan X +9 more
europepmc +2 more sources
Krüppel-like factor 4 modulates the miR-101/COL10A1 axis to inhibit renal fibrosis after AKI by regulating epithelial-mesenchymal transition. [PDF]
Ren FailAcute kidney injury (AKI) can progress to renal fibrosis and chronic kidney disease (CKD), which reduces quality of life and increases the economic burden on patients.
Zhao J, Wang X, Wu Y, Zhao C.
europepmc +2 more sources
MicroRNA-92a-3p Enhances Cisplatin Resistance by Regulating Krüppel-Like Factor 4-Mediated Cell Apoptosis and Epithelial-to-Mesenchymal Transition in Cervical Cancer. [PDF]
Front Pharmacol, 2021 Recent studies have confirmed the existence and key roles of microRNA (miRNAs) in cancer drug resistance, including cervical cancer (CC). The present study aims to establish a novel role for miR-92a-3p and its associated gene networks in cisplatin (DDP ...
Yang J, Hai J, Dong X, Zhang M, Duan S.
europepmc +2 more sources
Frontiers in Pharmacology, 2020 Krüppel-like factor 4 (KLF4) is a transcription factor and plays a vital role in cancer initiation and development. However, the role of Krüppel-like factor 4 in the metastasis of non-small cell lung cancer (NSCLC) is not clear.
Yanping Wu +15 more
doaj +2 more sources
Krüppel-Like Factor 4 and Its Activator APTO-253 Induce NOXA-Mediated, p53-Independent Apoptosis in Triple-Negative Breast Cancer Cells. [PDF]
Genes (Basel), 2021 Inducing apoptosis is an effective treatment for cancer. Conventional cytotoxic anticancer agents induce apoptosis primarily through activation of tumor suppressor p53 by causing DNA damage and the resulting regulation of B-cell leukemia/lymphoma-2 (BCL ...
Nakajima W +4 more
europepmc +2 more sources
Krüppel-like Factor 4-Deficient Cells Are Sensitive to Etoposide-Induced DNA Damage [PDF]
Current Issues in Molecular BiologyKrüppel-like factor 4 (KLF4) is a highly conserved zinc-finger transcription factor involved in cellular processes such as development, differentiation, and cell cycle regulation.
Maxwell H. Rubinstein +5 more
doaj +2 more sources
Immune checkpoint inhibitor induces cardiac injury through polarizing macrophages via modulating microRNA-34a/Kruppel-like factor 4 signaling [PDF]
Cell Death and Disease, 2020 Cancer immunotherapy has become a well-established treatment option for some cancers; however, its use is hampered by its cardiovascular adverse effects. Immune checkpoint inhibitors (ICIs)-related cardiac toxicity took place in kinds of different forms,
Wenzheng Xia +4 more
openalex +2 more sources
Recent Discoveries on the Involvement of Krüppel-Like Factor 4 in the Most Common Cancer Types. [PDF]
Int J Mol Sci, 2020 Krüppel-like factor 4 (KLF4) is a transcription factor highly conserved in evolution. It is particularly well known for its role in inducing pluripotent stem cells. In addition, KLF4 plays many roles in cancer.
Taracha-Wisniewska A +3 more
europepmc +2 more sources
Doxycycline inducible Krüppel-like factor 4 lentiviral vector mediates mesenchymal to epithelial transition in ovarian cancer cells. [PDF]
PLoS ONE, 2014 Ovarian cancer presents therapeutic challenges due to its typically late detection, aggressive metastasis, and therapeutic resistance. The transcription factor Krüppel-like factor 4 (KLF4) has been implicated in human cancers as a tumor suppressor or ...
Zixuan Chen +12 more
doaj +3 more sources