Results 21 to 30 of about 723,697 (239)

Krüppel-like factor-4 and Krüppel-like factor-2 are important regulators of joint tissue cells and protect against tissue destruction and inflammation in osteoarthritis. [PDF]

Ann Rheum Dis, 2022
Objectives Analysing expression patterns of Krüppel-like factor (KLF) transcription factors in normal and osteoarthritis (OA) human cartilage, and determining functions and mechanisms of KLF4 and KLF2 in joint homoeostasis and OA pathogenesis.
Kawata M, Teramura T, Ordoukhanian P, Head SR, Natarajan P, Sundaresan A, Olmer M, Asahara H, Lotz MK.   +8 more
europepmc   +2 more sources

Involvement of miRNA-34a regulated Krüppel-like factor 4 expression in hyperoxia-induced senescence in lung epithelial cells. [PDF]

Respir Res, 2022
Background Premature infants, subjected to supplemental oxygen and mechanical ventilation, may develop bronchopulmonary dysplasia, a chronic lung disease characterized by alveolar dysplasia and impaired vascularization.
Maeda H, Yao H, Go H, Huntington KE, De Paepe ME, Dennery PA.   +5 more
europepmc   +2 more sources

Decreased Krüppel-like factor 4 in adenomyosis impairs decidualization by repressing autophagy in human endometrial stromal cells. [PDF]

BMC Mol Cell Biol, 2022
Poor decidualization and abnormal autophagy conditions in the endometria of adenomyosis patients have been reported previously. However, the specific regulatory mechanism of decidualization in adenomyosis and its relationship with autophagy levels have ...
Mei J, Sheng X, Yan Y, Cai X, Zhang C, Tian J, Zhang M, Zhou J, Shan H, Huang C.   +9 more
europepmc   +2 more sources

MicroRNA-92a-3p Enhances Cisplatin Resistance by Regulating Krüppel-Like Factor 4-Mediated Cell Apoptosis and Epithelial-to-Mesenchymal Transition in Cervical Cancer. [PDF]

Front Pharmacol, 2021
Recent studies have confirmed the existence and key roles of microRNA (miRNAs) in cancer drug resistance, including cervical cancer (CC). The present study aims to establish a novel role for miR-92a-3p and its associated gene networks in cisplatin (DDP ...
Yang J, Hai J, Dong X, Zhang M, Duan S.
europepmc   +2 more sources

Deletion of Krüppel-like factor-4 promotes axonal regeneration in mammals. [PDF]

Neural Regen Res, 2021
Axonal regeneration plays an important role in functional recovery after nervous system damage. However, after axonal injury in mammals, regeneration is often poor.
Xu JH, Qin XZ, Zhang HN, Ma YX, Qi SB, Zhang HC, Ma JJ, Fu XY, Xie JL, Saijilafu.   +9 more
europepmc   +2 more sources

Transcription factors Krüppel-like factor 4 and paired box 5 regulate the expression of the Grainyhead-like genes. [PDF]

PLoS One, 2021
Genes from the Grainyhead-like (GRHL) family code for transcription factors necessary for the development and maintenance of various epithelia. These genes are also very important in the development of many types of cancer. However, little is known about
Kotarba G, Taracha-Wisniewska A, Miller M, Dabrowski M, Wilanowski T.   +4 more
europepmc   +2 more sources

Mesenchymal Mycn participates in odontoblastic lineage commitment by regulating Krüppel-like Factor 4 (Klf4) in mice. [PDF]

Stem Cell Res Ther, 2022
Background Commitment of mouse dental papilla cells (mDPCs) to the odontoblast lineage is critical for dentin formation, and this biological process is regulated by a complex transcription factor network. The transcription factor Mycn is a proto-oncogene
Huang Z, Yang R, Li R, Zuo Y, Gu F, He M, Bian Z.   +6 more
europepmc   +2 more sources

Krüppel-Like Factor 4 and Its Activator APTO-253 Induce NOXA-Mediated, p53-Independent Apoptosis in Triple-Negative Breast Cancer Cells. [PDF]

Genes (Basel), 2021
Inducing apoptosis is an effective treatment for cancer. Conventional cytotoxic anticancer agents induce apoptosis primarily through activation of tumor suppressor p53 by causing DNA damage and the resulting regulation of B-cell leukemia/lymphoma-2 (BCL ...
Nakajima W, Miyazaki K, Asano Y, Kubota S, Tanaka N.   +4 more
europepmc   +2 more sources

Intestinal epithelial Krüppel-like factor 4 alleviates endotoxemia and atherosclerosis through improving NF-κB/miR-34a-mediated intestinal permeability. [PDF]

Acta Pharmacol Sin
Nie HZ, Zhou YW, Yu XH, Yin CG, Li LF, Hao HQ, Yuan T, Pan Y.   +7 more
europepmc   +2 more sources

Recent Discoveries on the Involvement of Krüppel-Like Factor 4 in the Most Common Cancer Types. [PDF]

Int J Mol Sci, 2020
Krüppel-like factor 4 (KLF4) is a transcription factor highly conserved in evolution. It is particularly well known for its role in inducing pluripotent stem cells. In addition, KLF4 plays many roles in cancer.
Taracha-Wisniewska A, Kotarba G, Dworkin S, Wilanowski T.   +3 more
europepmc   +2 more sources