Results 41 to 50 of about 723,697 (239)

Platelet factor 4 regulation of monocyte KLF4 in experimental cerebral malaria. [PDF]

PLoS ONE, 2010
Cerebral malaria continues to be a difficult to treat complication of Plasmodium falciparum infection in children. We have shown that platelets can have major deleterious immune functions in experimental cerebral malaria (ECM).
Kalyan Srivastava, David J Field, Angela Aggrey, Munekazu Yamakuchi, Craig N Morrell   +4 more
doaj   +1 more source

KLF4 alleviates cerebral vascular injury by ameliorating vascular endothelial inflammation and regulating tight junction protein expression following ischemic stroke

Journal of Neuroinflammation, 2020
Background Although inflammatory cell adhesion molecules (CAMs) and anti-inflammation factor Kruppel-like transcription factor (KLF) 4 have all been reported to be induced after cerebral ischemic stroke (CIS), the close temporal and spatial relationship ...
Xinyu Zhang, Lu Wang, Zhenxiang Han, Jing Dong, Defang Pang, Yuan Fu, Longxuan Li   +6 more
doaj   +1 more source

Induction of Krüppel-Like Factor 4 Mediates Polymorphonuclear Neutrophil Activation in Streptococcus pneumoniae Infection. [PDF]

Front Microbiol, 2020
The recruitment and activation of polymorphonuclear neutrophils (PMNs) are of central importance for the elimination of pathogens in bacterial infections.
Bhattacharyya A, Herta T, Conrad C, Frey D, García P, Suttorp N, Hippenstiel S, Zahlten J.   +7 more
europepmc   +2 more sources

Immune checkpoint inhibitor induces cardiac injury through polarizing macrophages via modulating microRNA-34a/Kruppel-like factor 4 signaling

Cell Death and Disease, 2020
Cancer immunotherapy has become a well-established treatment option for some cancers; however, its use is hampered by its cardiovascular adverse effects. Immune checkpoint inhibitors (ICIs)-related cardiac toxicity took place in kinds of different forms,
Wenzheng Xia, C. Zou, Hanbin Chen, C. Xie, Meng Hou   +4 more
semanticscholar   +1 more source

Albendazole induces the terminal differentiation of acute myeloid leukaemia cells to monocytes by stimulating the Krüppel‐like factor 4‐dihydropyrimidinase‐like 2A (KLF4‐DPYSL2A) axis

British Journal of Haematology, 2021
Differentiation therapy is a less toxic but still a very effective treatment for a subset of acute myeloid leukaemia (AML) cases. With the goal to identify novel compounds that can effectively and safely induce the terminal differentiation of non‐acute ...
M. Noura, K. Morita, Hiroki Kiyose, Y. Okuno, H. Matsuo, Asami Koyama, Yoko Nishinaka-Arai, Yasuhiko Kamikubo, S. Adachi   +8 more
semanticscholar   +1 more source

Kruppel-like factor 4 inhibits non–small cell lung cancer cell growth and aggressiveness by stimulating transforming growth factor-β1-meidated ERK/JNK/NF-κB signaling pathways

Tumor Biology, 2017
Non–small cell lung cancer is one of the most common epithelial tumors that cause the most common cancer-related mortality due to invasive ability. Research has found that Kruppel-like factor 4, a zinc-finger transcription factor, plays a critical role ...
Renzhi Yu, Lei Han, Xin Ni, Minghuan Wang, Ping Xue, Li Zhang, Mei Yuan   +6 more
doaj   +1 more source

Mechanism of histone deacetylases in cardiac hypertrophy and its therapeutic inhibitors

Frontiers in Cardiovascular Medicine, 2022
Cardiac hypertrophy is a key process in cardiac remodeling development, leading to ventricle enlargement and heart failure. Recently, studies show the complicated relation between cardiac hypertrophy and epigenetic modification.
Yu Han, Yu Han, Jiali Nie, Jiali Nie, Dao Wen Wang, Dao Wen Wang, Li Ni, Li Ni   +7 more
doaj   +1 more source

Association of Expression of Kruppel-Like Factor 4 and Kruppel-Like Factor 5 with the Clinical Manifestations of Breast Cancer

Pathology & Oncology Research, 2011
Kruppel-like factors (KLFs) are import modulators of cell proliferation, differentiation, and transformation and have recently been considered possible prognostic factors in breast cancer. In this study, we investigated the correlation between KLF4 and KLF5 expression and the clinical manifestations of breast cancer by immunohistochemical analysis.
Shu Hui Lin, Sey-En Lin, Chih Jung Chen, Dar Ren Chen, Yueh Min Lin, Chi Long Chen   +5 more
openaire   +3 more sources

High expression of Kruppel-like factor 4 as a predictor of poor prognosis for cervical cancer patient response to radiotherapy

Tumor Biology, 2017
Purpose: The aim of this study was to explore the associations of Kruppel-like factor 4 expression with sensitivity to radiation therapy in locally advanced cervical squamous cell carcinoma patients.
Hai-Xia Liu, Na Li, Li Wei, Fu-Xing Zhou, Rui Ma, Feng Xiao, Wei Zhang, Ying Zhang, Yan-ping Hui, Hui Song, Bi-Liang Chen   +10 more
doaj   +1 more source

Differential Expression of miR-34c and Its Predicted Target Genes in Testicular Tissue at Different Development Stages of Swine [PDF]

Asian-Australasian Journal of Animal Sciences, 2015
To verified the target genes of miR-34c, bioinformatics software was used to predict the targets of miR-34c. Three possible target genes of miR-34c related to spermatogenesis and male reproductive development: zinc finger protein 148 (ZNF148), kruppel ...
Xiaojun Zhang, Wei Zhao, Chuanmin Li, Haibin Yu, YanYan Qiao, Aonan Li, Chunyan Lu, Zhihui Zhao, Boxing Sun   +8 more
doaj   +1 more source