Results 51 to 60 of about 157,775 (261)

Krüppel-like factor 4 regulates intestinal epithelial cell morphology and polarity. [PDF]

PLoS ONE, 2012
Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor that plays a vital role in regulating cell lineage differentiation during development and maintaining epithelial homeostasis in the intestine.
Tianxin Yu, Xi Chen, Wen Zhang, Juan Li, Ren Xu, Timothy C Wang, Walden Ai, Chunming Liu   +7 more
doaj   +1 more source

Endothelial Kruppel-like factor 4 protects against atherothrombosis in mice [PDF]

Journal of Clinical Investigation, 2012
The endothelium regulates vascular homeostasis, and endothelial dysfunction is a proximate event in the pathogenesis of atherothrombosis. Stimulation of the endothelium with proinflammatory cytokines or exposure to hemodynamic-induced disturbed flow leads to a proadhesive and prothrombotic phenotype that promotes atherothrombosis. In contrast, exposure
Guangjin, Zhou, Anne, Hamik, Lalitha, Nayak, Hongmei, Tian, Hong, Shi, Yuan, Lu, Nikunj, Sharma, Xudong, Liao, Andrew, Hale, Lauren, Boerboom, Ryan E, Feaver, Huiyun, Gao, Amar, Desai, Alvin, Schmaier, Stanton L, Gerson, Yunmei, Wang, G Brandon, Atkins, Brett R, Blackman, Daniel I, Simon, Mukesh K, Jain   +19 more
openaire   +2 more sources

Opposing effects of Kruppel-like factor 4 (gut-enriched Kruppel-like factor) and Kruppel-like factor 5 (intestinal-enriched Kruppel-like factor) on the promoter of the Kruppel-like factor 4 gene [PDF]

Nucleic Acids Research, 2002
KLF4 (Krüppel-like factor 4 or gut-enriched Krüppel-like factor, GKLF) and KLF5 (Krüppel-like factor 5 or intestinal-enriched Krüppel-like factor, IKLF) are two closely related members of the zinc finger-containing Krüppel-like factor family of transcription factors.
Duyen T, Dang, Weidong, Zhao, Channing S, Mahatan, Deborah E, Geiman, Vincent W, Yang   +4 more
openaire   +2 more sources

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

KLF4 (Kruppel-Like Factor 4)-Dependent Perivascular Plasticity Contributes to Adipose Tissue inflammation [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2021
Objective: Smooth muscle cells and pericytes display remarkable plasticity during injury and disease progression. Here, we tested the hypothesis that perivascular cells give rise to Klf4 -dependent macrophage-like cells that augment adipose tissue (AT) inflammation and metabolic ...
Gamze B. Bulut, Gabriel F. Alencar, Katherine M. Owsiany, Anh T. Nguyen, Santosh Karnewar, Ryan M. Haskins, Lillian K. Waller, Olga A. Cherepanova, Rebecca A. Deaton, Laura S. Shankman, Susanna R. Keller, Gary K. Owens   +11 more
openaire   +2 more sources

Krüppel-like factor 4 promotes the proliferation and osteogenic differentiation of BMSCs through SOX2/IGF2 pathway.

Acta Biochimica Polonica, 2022
OBJECTIVES Human bone marrow mesenchymal stem cells (BMSCs) have multi-lineage differentiation potential and have been widely researched in regenerative medicine.
Z. Fei, Chengcheng Sun, Xiaoqiang Peng, Mu Han, Qi-Jia Zhou   +4 more
semanticscholar   +1 more source

Kruppel-like factor 4 expression in normal and pathological human testes [PDF]

Molecular Human Reproduction, 2007
Krüppel-like factor 4 (KLF4) is a transcription factor involved in many cellular and developmental processes such as terminal differentiation of cells and carcinogenesis. Mice lacking KLF4 die post-natally due to skin barrier deficiencies and exhibit several additional cellular defects. The adult rodent testis expresses high levels of Klf4 mRNA.
Behr, R., Deller, C., Godmann, M., Muller, T., Bergmann, M., Ivell, R., Steger, K.   +6 more
openaire   +4 more sources

The critical role of KLF4 in regulating the activation of A1/A2 reactive astrocytes following ischemic stroke

Journal of Neuroinflammation, 2023
Background We have previously demonstrated that the expression of kruppel-like transcription factor-4 (KLF-4) is upregulated in astrocytes following acute ischemic stroke (AIS) and found that KLF4 confers vascular protection against cerebral ischemic ...
Cong Wang, Longxuan Li
doaj   +1 more source

Botanical Antcin K Alleviates High-Fat Damage in Palm Acid Oil-Treated Vascular Endothelial Cells and Macrophages

Plants, 2022
Lipid metabolism disorder is the most critical risk factor for atherosclerosis, and the process involves lipid deposition in the arterial intima. In Taiwan, antcin K, an active triterpenoid from the fruiting bodies of Antrodia camphorata, has been ...
Chen-Wen Lu, Ngan Thi Kim Nguyen, Szu-Chuan Shen, Yeh-Bin Wu, Hui-Ju Liang, Chung-Hsin Wu   +5 more
doaj   +1 more source

Kruppel-Like Factor 4 Is Essential for Inflammatory Monocyte Differentiation In Vivo. [PDF]

Blood, 2007
Abstract Several members of the Kruppel-like factor (KLF) family of transcription factors play important roles in differentiation, survival, and trafficking of blood and immune cell types. We demonstrate here that hematopoietic cells from KLF4−/− fetal livers (FL) contained normal numbers of functional hematopoietic progenitor cells ...
Jonathan K, Alder, Robert W, Georgantas, Richard L, Hildreth, Ian M, Kaplan, Sebastien, Morisot, Xiaobing, Yu, Michael, McDevitt, Curt I, Civin   +7 more
openaire   +2 more sources