Results 61 to 70 of about 157,775 (261)

Reversing Blood Flows Act through klf2a to Ensure Normal Valvulogenesis in the Developing Heart [PDF]

, 2009
Heart valve anomalies are some of the most common congenital heart defects, yet neither the genetic nor the epigenetic forces guiding heart valve development are well understood.
A. C Oates, A. F Hurlstone, A. F Moorman, A. G Passerini, A. M Malek, A. R Brooks, A. S Forouhar, Arian S. Forouhar, B. C Groenendijk, B. C Groenendijk, C Ethier, C Hahn, C. H Kim, D Beis, D. J Milan, David Wu, Diane Plummer, E Berdougo, E. C Walsh, E. J Armstrong, G Bendig, G Garcia-Cardena, G. B Atkins, G. P Sorescu, H Kokubo, H. J Auman, Hiroshi Hamada, J Alexander, J Pan, J. L Galloway, J. N Chen, J. R Hove, J. S Lee, Julien Vermot, K. M Parmar, L. A Timmerman, M Liebling, M Xin, M Yamada, Michael Liebling, Morteza Gharib, N Sultana, N. C Chi, N. C Chi, P. J Scherz, R. D Kortschak, R. J Dekker, R. J Dekker, S Isogai, S Quintin, S. M McCormick, S. M Meadows, S. W Jin, Scott E. Fraser, T Bartman, T Bartman, T Lecuit, T Lecuit, T. R Cummins, X. L Wang, Y Fung   +60 more
core   +9 more sources

Gene Expression Profile Changes After Short-activating RNA-mediated Induction of Endogenous Pluripotency Factors in Human Mesenchymal Stem Cells [PDF]

, 2012
It is now recognized that small noncoding RNA sequences have the ability to mediate transcriptional activation of specific target genes in human cells.
Alluin, J, Habib, N, Kasahara, N, Mintz, P, Rossi, J, Sun, G, Sætrom, P, Voutila, J   +7 more
core   +4 more sources

Albendazole induces the terminal differentiation of acute myeloid leukaemia cells to monocytes by stimulating the Krüppel‐like factor 4‐dihydropyrimidinase‐like 2A (KLF4‐DPYSL2A) axis

British Journal of Haematology, 2021
Differentiation therapy is a less toxic but still a very effective treatment for a subset of acute myeloid leukaemia (AML) cases. With the goal to identify novel compounds that can effectively and safely induce the terminal differentiation of non‐acute ...
M. Noura, K. Morita, Hiroki Kiyose, Y. Okuno, H. Matsuo, Asami Koyama, Yoko Nishinaka-Arai, Yasuhiko Kamikubo, S. Adachi   +8 more
semanticscholar   +1 more source

Branched-Chain Amino Acid Negatively Regulates KLF15 Expression via PI3K-AKT Pathway. [PDF]

, 2017
Recent studies have linked branched-chain amino acid (BCAA) with numerous metabolic diseases. However, the molecular basis of BCAA's roles in metabolic regulation remains to be established.
Dong, Weibing, Liu, Yunxia, Shao, Jing, Sun, Haipeng, Wang, Yibin, Zhou, Meiyi   +5 more
core   +2 more sources

Krüppel-Like Factor 4 Is a Regulator of Proinflammatory Signaling in Fibroblast-Like Synoviocytes through Increased IL-6 Expression

Mediators of Inflammation, 2016
Human fibroblast-like synoviocytes play a vital role in joint synovial inflammation in rheumatoid arthritis (RA). Proinflammatory cytokines induce fibroblast-like synoviocyte activation and dysfunction.
Xinjing Luo, Jie Chen, Jianwei Ruan, Yongfeng Chen, Xuanrong Mo, Jiangwen Xie, Guoju Lv   +6 more
doaj   +1 more source

Krüppel-like factors in cancer progression: three fingers on the steering wheel [PDF]

, 2013
Kruppel-like factors (KLFs) comprise a highly conserved family of zinc finger transcription factors, that are involved in a plethora of cellular processes, ranging from proliferation and apoptosis to differentiation, migration and pluripotency.
de Beeck, Ken Op, De Wever, Olivier, Lardon, Filip, LIMAME, RIDHA, Pauwels, Patrick   +4 more
core   +3 more sources

Kruppel-like factor 4 inhibits non–small cell lung cancer cell growth and aggressiveness by stimulating transforming growth factor-β1-meidated ERK/JNK/NF-κB signaling pathways

Tumor Biology, 2017
Non–small cell lung cancer is one of the most common epithelial tumors that cause the most common cancer-related mortality due to invasive ability. Research has found that Kruppel-like factor 4, a zinc-finger transcription factor, plays a critical role ...
Renzhi Yu, Lei Han, Xin Ni, Minghuan Wang, Ping Xue, Li Zhang, Mei Yuan   +6 more
doaj   +1 more source

Elevated Krüppel-like factor 4 transcription factor in canine mammary carcinoma

BMC Veterinary Research, 2011
Background Krüppel-like factors (KLFs) are critical regulators of biological and physiological systems and have been extensively studied for their roles in cell proliferation, differentiation and survival in the context of cancer. Among the KLFs, KLF4 is
Yeh Kun-Tu, Liao Albert, Hsu Nicholas, Chu Pei-Yi, Hou Ming-Feng, Liu Chen-Hsuan   +5 more
doaj   +1 more source

Therapeutic targeting of Krüppel-like factor 4 abrogates microglial activation

Journal of Neuroinflammation, 2012
Background Neuroinflammation occurs as a result of microglial activation in response to invading micro-organisms or other inflammatory stimuli within the central nervous system.
Kaushik Deepak, Mukhopadhyay Rupanjan, Kumawat Kanhaiya, Gupta Malvika, Basu Anirban   +4 more
doaj   +1 more source

High expression of Kruppel-like factor 4 as a predictor of poor prognosis for cervical cancer patient response to radiotherapy

Tumor Biology, 2017
Purpose: The aim of this study was to explore the associations of Kruppel-like factor 4 expression with sensitivity to radiation therapy in locally advanced cervical squamous cell carcinoma patients.
Hai-Xia Liu, Na Li, Li Wei, Fu-Xing Zhou, Rui Ma, Feng Xiao, Wei Zhang, Ying Zhang, Yan-ping Hui, Hui Song, Bi-Liang Chen   +10 more
doaj   +1 more source