Results 61 to 70 of about 723,697 (239)

Composite Quantile Factor Model [PDF]

arXiv, 2023
This paper introduces the method of composite quantile factor model for factor analysis in high-dimensional panel data. We propose to estimate the factors and factor loadings across multiple quantiles of the data, allowing the estimates to better adapt to features of the data at different quantiles while still modeling the mean of the data.
arxiv  

KLF4 (Kruppel-Like Factor 4)-Dependent Perivascular Plasticity Contributes to Adipose Tissue inflammation [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2021
Objective: Smooth muscle cells and pericytes display remarkable plasticity during injury and disease progression. Here, we tested the hypothesis that perivascular cells give rise to Klf4 -dependent macrophage-like cells that augment adipose tissue (AT) inflammation and metabolic ...
Gamze B. Bulut, Gabriel F. Alencar, Katherine M. Owsiany, Anh T. Nguyen, Santosh Karnewar, Ryan M. Haskins, Lillian K. Waller, Olga A. Cherepanova, Rebecca A. Deaton, Laura S. Shankman, Susanna R. Keller, Gary K. Owens   +11 more
openaire   +3 more sources

Acquisition of cancer stem cell properties in osteosarcoma cells by defined factors

Stem Cell Research & Therapy, 2020
Background Cancer stem cells (CSCs) are considered to be responsible for tumor initiation, formation, and poor prognosis of cancer patients. However, the rarity of CSCs in clinical samples makes it difficult to elucidate characteristics of CSCs ...
Shuichi Fujiwara, Teruya Kawamoto, Yohei Kawakami, Yasufumi Koterazawa, Hitomi Hara, Toshiyuki Takemori, Kazumichi Kitayama, Shunsuke Yahiro, Kenichiro Kakutani, Tomoyuki Matsumoto, Takehiko Matsushita, Takahiro Niikura, Michiyo Koyanagi-Aoi, Takashi Aoi, Ryosuke Kuroda, Toshihiro Akisue   +15 more
doaj   +1 more source

Factorizations of relative extremal projectors [PDF]

p-Adic Numbers Ultrametric Anal. Appl. 7 (2015), no. 4, 276-290, 2015
We survey earlier results on factorizations of extremal projectors and relative extremal projectors and present preliminary results on non-commutative factorizations of relative extremal projectors: we deduce the existence of such factorizations for sl(4) and sl(5).
arxiv   +1 more source

Multivariate to Bivariate Reduction for Noncommutative Polynomial Factorization [PDF]

arXiv, 2023
Based on a theorem of Bergman we show that multivariate noncommutative polynomial factorization is deterministic polynomial-time reducible to the factorization of bivariate noncommutative polynomials. More precisely, we show the following: (1) In the white-box setting, given an n-variate noncommutative polynomial f in F over a field F (either a ...
arxiv  

Klf4 is a transcriptional regulator of genes critical for EMT, including Jnk1 (Mapk8). [PDF]

PLoS ONE, 2013
We have identified the zinc-finger transcription factor Kruppel-like factor 4 (Klf4) among the transcription factors that are significantly downregulated in their expression during epithelial-mesenchymal transition (EMT) in mammary epithelial cells and ...
Neha Tiwari, Nathalie Meyer-Schaller, Phil Arnold, Helena Antoniadis, Mikhail Pachkov, Erik van Nimwegen, Gerhard Christofori   +6 more
doaj   +1 more source

Overexpression of Krüppel-Like Factor 4 Suppresses Migration and Invasion of Non-Small Cell Lung Cancer Through c-Jun-NH2-Terminal Kinase/Epithelial-Mesenchymal Transition Signaling Pathway

Frontiers in Pharmacology, 2020
Krüppel-like factor 4 (KLF4) is a transcription factor and plays a vital role in cancer initiation and development. However, the role of Krüppel-like factor 4 in the metastasis of non-small cell lung cancer (NSCLC) is not clear.
Yanping Wu, Lianjun Lin, Xiang Wang, Yong Li, Zhonghui Liu, Wei-xia Ye, Weiming Huang, G. Lin, Haibo Liu, Ji-xin Zhang, Tingting Li, Beilei Zhao, Liping Lv, Jian Li, Nanping Wang, Xinmin Liu   +15 more
semanticscholar   +1 more source

Dysregulation of Kruppel-like factor 4 during brain development leads to hydrocephalus in mice [PDF]

Proceedings of the National Academy of Sciences, 2011
Kruppel-like factor 4 (KLF4) is involved in self-renewal of embryonic stem cells and reprogramming of somatic cells to pluripotency. However, its role in lineage-committed stem cells remains largely unknown. Here, we show that KLF4 is expressed in neural stem cells (NSCs) and is down-regulated during neuronal differentiation.
Chun Li Zhang, Song Qin, Wenze Niu, Menglu Liu   +3 more
openaire   +2 more sources

Tumor-suppressive role of Kruppel-like factor 4 (KLF-4) in colorectal cancer

Genetics and Molecular Research, 2017
Kruppel-like factors (KLFs) are a group of transcriptional regulators that have recently been identified to exhibit tumor-suppressive function against various gastrointestinal cancers. The present study aims to investigate the expression patterns and prognostic value of KLF-4 in colorectal cancers (CRCs).
Guifeng Liu, Dianhui Xiu, Yan Chen, Haishan Yang, Lianhe Liu   +4 more
openaire   +3 more sources

Transcription Factors as Therapeutic Targets in Chronic Kidney Disease

Molecules, 2018
The growing number of patients with chronic kidney disease (CKD) is recognized as an emerging problem worldwide. Recent studies have indicated that deregulation of transcription factors is associated with the onset or progression of kidney disease ...
Akihito Hishikawa, Kaori Hayashi, Hiroshi Itoh   +2 more
doaj   +1 more source